Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 16, 2024
Abstract
Background
Tar
is
the
main
toxic
of
cigarettes,
and
its
effect
on
atherosclerosis
progression
underlying
mechanisms
remain
largely
unknown.
Vascular
smooth
muscle
cells
(VSMCs)
play
a
key
role
in
atherogenesis
plaque
vulnerability.
The
present
study
sought
to
investigate
mechanism
through
tar-induced
VSMC
necroptosis,
recently
described
form
necrosis.
Methods
tar
necroptosis
was
examined
ApoE
−/−
mice
cultured
VSMCs.
development
evaluated
RIPK3-deletion
(ApoE
RIPK3
).
proteins
carotid
plaques
smokers
non-smokers
were
also
examined.
Quantitative
proteomics
aortas
conducted
further
mechanism.
Pharmacological
approaches
then
applied
modulate
expression
targets
verify
regulatory
process
necroptosis.
Results
administration
led
increased
atherosclerotic
area
reduced
collagen
VSMCs
mice.
RIPK1、RIPK3、and
MLKL
all
tar-exposed
smokers.
deletion
protected
against
loss
stimulated
by
tar.
In
mechanistic
studies,
quantitative
analysis
suggested
that
triggered
endoplasmic
reticulum
(ER)
stress.
PERK-eIF2α-CHOP
axis
activated
tar-treated
plaque.
Inhibition
ER
stress
using
4PBA
significantly
Further
revealed
resulted
calcium
(Ca
2+
)
release
into
mitochondria
cytoplasm.
Elevated
Ca
levels
lead
mitochondrial
dysfunction
excessive
reactive
oxygen
species
(ROS)
production,
which
consequently
promote
RIPK3-dependent
addition,
/calmodulin-dependent
protein
kinase
II
(CaMKII)
cytosolic
overload
binds
RIPK3,
accounting
for
Conclusion
findings
cigarette
promoted
inducing
identified
novel
avenues
overload.
Molecules,
Год журнала:
2024,
Номер
29(5), С. 948 - 948
Опубликована: Фев. 21, 2024
Extracellular
vesicles
(EVs)
are
small
phospholipid
bilayer-bond
structures
released
by
diverse
cell
types
into
the
extracellular
environment,
maintaining
homeostasis
of
balancing
cellular
stress.
This
article
provides
a
comprehensive
overview
vesicles,
their
heterogeneity,
and
diversified
roles
in
processes,
emphasizing
importance
elimination
unwanted
molecules.
They
play
role
regulating
oxidative
stress,
particularly
discarding
oxidized
toxic
Furthermore,
endoplasmic
reticulum
stress
induces
release
EVs,
contributing
to
distinct
results,
including
autophagy
or
ER
transmission
following
cells.
stress-induced
is
part
unfolded
protein
response
(UPR)
protects
cells
from
stress-related
apoptosis.
Mitochondrial-derived
(MDVs)
also
homeostasis,
as
they
carry
damaged
mitochondrial
components,
thereby
preventing
inflammation.
Moreover,
EVs
partake
aging-related
therefore
can
potentially
crucial
anti-aging
therapies,
treatment
age-related
diseases
such
Alzheimer’s
disease
cardiovascular
conditions.
Overall,
purpose
this
provide
better
understanding
significant
mediators
both
physiological
pathological
shed
light
on
potential
for
therapeutic
interventions
targeting
EV-mediated
pathways
various
conditions,
with
an
emphasis
diseases.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Март 4, 2024
Type
2
diabetes
mellitus
(T2DM)
poses
a
significant
global
health
burden.
This
is
particularly
due
to
its
macrovascular
complications,
such
as
coronary
artery
disease,
peripheral
vascular
and
cerebrovascular
which
have
emerged
leading
contributors
morbidity
mortality.
review
comprehensively
explores
the
pathophysiological
mechanisms
underlying
these
protective
strategies,
both
existing
emerging
secondary
preventive
measures.
Furthermore,
we
delve
into
applications
of
experimental
models
methodologies
in
foundational
research
while
also
highlighting
current
limitations
future
directions.
Specifically,
focus
on
literature
published
post-2020
concerning
prevention
complications
patients
with
T2DM
by
conducting
targeted
studies
supported
robust
evidence
offer
holistic
perspective.
Materials Today Bio,
Год журнала:
2023,
Номер
22, С. 100757 - 100757
Опубликована: Авг. 3, 2023
The
aim
of
this
paper
is
to
offer
a
narrative
review
the
literature
regarding
influence
transition
metals
on
angiogenesis,
excluding
lanthanides
and
actinides.
To
our
knowledge
there
are
not
any
reviews
up
date
offering
such
summary,
which
inclined
us
write
paper.
Angiogenesis
describes
process
blood
vessel
formation,
an
essential
requirement
for
human
growth
development.
When
complex
interplay
between
pro-
antiangiogenic
mediators
falls
out
balance,
angiogenesis
can
quickly
become
harmful.
As
it
so
fundamental,
both
its
inhibition
enhancement
take
part
in
various
diseases,
making
target
therapeutic
treatments.
Current
methods
come
with
limitations,
therefore,
novel
agents
constantly
being
researched,
metal
promising
results.
Various
have
already
been
investigated
in-depth,
studies
indicating
properties,
respectively.
applied
formulations,
as
nanoparticles,
complexes,
or
scaffold
materials.
Albeit
increasing
attention
field
receiving,
remain
many
unanswered
questions,
mostly
molecular
mechanisms
behind
observed
effects.
Notably,
approximately
half
all
yet
potential
angiogenic
Considering
results
established,
should
be
great
interest
begin
investigating
remaining
elements
whilst
also
further
analyzing
established
Pharmaceuticals,
Год журнала:
2024,
Номер
17(3), С. 353 - 353
Опубликована: Март 8, 2024
Many
pathologic
states
can
lead
to
the
accumulation
of
unfolded/misfolded
proteins
in
cells.
This
causes
endoplasmic
reticulum
(ER)
stress
and
triggers
unfolded
protein
response
(UPR),
which
encompasses
three
main
adaptive
branches.
One
these
UPR
branches
is
mediated
by
kinase
RNA-like
ER
(PERK),
an
sensor.
The
primary
consequence
PERK
activation
suppression
global
synthesis,
reduces
workload
facilitates
recovery
function.
Ischemic
stroke
induces
activates
UPR.
Studies
have
demonstrated
involvement
pathway
pathophysiology;
however,
its
role
outcomes
requires
further
clarification.
Importantly,
considering
mounting
evidence
that
supports
therapeutic
potential
aging-related
cognitive
decline
neurodegenerative
diseases,
this
may
represent
a
promising
target
stroke.
Therefore,
review,
our
aim
discuss
current
understanding
ischemic
stroke,
summarize
pharmacologic
tools
for
translational
research
targets
associated
pathways.
Expert Review of Proteomics,
Год журнала:
2025,
Номер
22(1), С. 19 - 33
Опубликована: Янв. 2, 2025
Introduction
Mitochondria
contain
multiple
pathways
including
energy
metabolism
and
several
signaling
synthetic
pathways.
Mitochondrial
proteomics
is
highly
valuable
for
studying
diseases
inherited
metabolic
disorders,
complex
common
disorders
like
neurodegeneration,
diabetes
cancer,
since
they
all
to
some
degree
have
mitochondrial
underpinnings.
