Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 24, 2025
Exosomes,
as
key
mediators
of
intercellular
communication,
have
been
increasingly
recognized
for
their
role
in
the
oncogenic
processes,
particularly
facilitating
drug
resistance.
This
article
delves
into
emerging
evidence
linking
exosomal
lncRNAs
to
modulation
resistance
mechanisms
cancers
such
ovarian,
cervical,
and
endometrial
cancer.
It
synthesizes
current
research
findings
on
how
these
influence
cancer
cell
survival,
tumor
microenvironment,
chemotherapy
efficacy.
Additionally,
review
highlights
potential
therapeutic
strategies
targeting
lncRNAs,
proposing
a
new
frontier
overcoming
By
mapping
interface
resistance,
this
aims
provide
comprehensive
understanding
that
could
pave
way
innovative
treatments
improved
patient
outcomes
female
reproductive
system
cancers.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7794 - 7794
Опубликована: Июль 16, 2024
Exosomes,
small
membrane-bound
vesicles
secreted
by
cells,
have
gained
significant
attention
for
their
therapeutic
potential.
Measuring
30–100
nm
in
diameter
and
derived
from
various
cell
types,
exosomes
play
a
crucial
role
intercellular
communication
transferring
proteins,
lipids,
RNA
between
cells.
This
review
analyzes
existing
literature
on
the
clinical
applications
of
exosomes.
We
conducted
comprehensive
search
peer-reviewed
articles
trial
data
to
evaluate
benefits,
limitations,
challenges
exosome-based
therapies.
Key
areas
focus
included
regenerative
medicine,
cancer
therapy,
gene
diagnostic
biomarkers.
highlights
vast
In
facilitate
tissue
repair
regeneration.
can
deliver
agents
directly
tumor
serve
as
vectors
delivery.
As
biomarkers,
they
are
useful
diagnosing
diseases.
Challenges
such
isolation,
purification,
characterization
were
identified.
Current
trials
demonstrate
potential
therapies,
though
also
reveal
hurdles.
Regulatory
issues,
including
need
standardization
validation
exosome
products,
critical
advancing
these
While
progress
has
been
made
understanding
biology,
further
research
is
essential
fully
unlock
Addressing
regulatory
successful
application
practice.
provides
concise
overview
exosomes,
emphasizing
both
promise
obstacles
that
be
overcome.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Фев. 13, 2024
Exosomes,
extracellular
vesicles
secreted
by
cells,
have
garnered
significant
attention
in
recent
years
for
their
remarkable
therapeutic
potential.
These
nanoscale
carriers
can
be
harnessed
the
targeted
delivery
of
agents,
such
as
pharmaceuticals,
proteins,
and
nucleic
acids,
across
biological
barriers.
This
versatile
attribute
exosomes
is
a
promising
modality
precision
medicine
applications,
notably
realm
cancer
therapy.
However,
despite
substantial
potential,
still
confront
challenges
tied
to
standardization
scalability
that
impede
practice
clinical
applications.
Moreover,
heterogeneity
isolation
methodologies
limited
cargo
loading
mechanisms
pose
obstacles
ensuring
consistent
outcomes,
thereby
constraining
utility.
In
contrast,
exhibit
distinct
advantage
diagnosis,
they
harbor
specific
signatures
reflective
tumor's
genetic
proteomic
profile.
characteristic
endows
them
with
potential
serve
valuable
liquid
biopsies
non-invasive
real-time
monitoring,
making
possible
early
detection
development
personalized
treatment
strategies.
this
review,
we
provide
an
extensive
evaluation
advancements
exosome
research,
critically
examining
advantages
limitations
context
therapy
diagnosis.
Furthermore,
present
curated
overview
most
technological
innovations
utilizing
exosomes,
focus
on
enhancing
efficacy
detection.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 10, 2024
Abstract
Exosomes
are
small
vesicles
of
endosomal
origin
that
released
by
almost
all
cell
types,
even
those
pathologically
altered.
widely
participate
in
cell-to-cell
communication
via
transferring
cargo,
including
nucleic
acids,
proteins,
and
other
metabolites,
into
recipient
cells.
Tumour-derived
exosomes
(TDEs)
many
important
molecular
pathways
affect
various
hallmarks
cancer,
fibroblasts
activation,
modification
the
tumour
microenvironment
(TME),
modulation
immune
responses,
angiogenesis
promotion,
setting
pre-metastatic
niche,
enhancing
metastatic
potential,
affecting
therapy
sensitivity
resistance.
The
unique
exosome
biogenesis,
composition,
nontoxicity,
ability
to
target
specific
cells
bring
up
their
use
as
promising
drug
carriers
cancer
biomarkers.
In
this
review,
we
focus
on
role
exosomes,
with
an
emphasis
protein
key
mechanisms
promoting
progression.
We
also
briefly
summarise
mechanism
its
structure,
potential
a
signalling
hub
both
normal
pathological
conditions.
Abstract
Liquid
biopsy
can
detect
circulating
cancer
cells
or
tumor
cell-derived
DNA
at
various
stages
of
cancer.
The
fluid
from
these
biopsies
contains
extracellular
vesicles
(EVs),
such
as
apoptotic
bodies,
microvesicles,
exomeres,
and
exosomes.
Exosomes
contain
proteins
nucleic
acids
(DNA/RNA)
that
modify
the
microenvironment
promote
progression,
playing
significant
roles
in
pathology.
Clinically,
within
exosomes
liquid
be
biomarkers
for
detection
prognosis
We
review
EVs
protein
miRNA
identified
select
cancers,
specifically
melanoma,
glioma,
breast,
pancreatic,
hepatic,
cervical,
prostate
colon,
some
hematological
malignancies.
Overall,
this
demonstrates
EV
biomolecules
have
great
potential
to
expand
diagnostic
prognostic
used
Oncology;
ultimately,
could
lead
earlier
novel
therapeutic
targets.
Clinical
implications
represent
a
new
paradigm
diagnostics
therapeutics.
use
exosomal
contents
indicators
may
facilitate
management.
Non-invasive
is
helpful,
especially
when
difficult
reach,
pancreatic
adenocarcinoma.
Moreover,
another
advantage
using
minimally
invasive
monitoring
becomes
more
manageable.
Identifying
tumor-derived
microRNAs
would
allow
personalized
approach
detecting
improving
treatment.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 24, 2025
Exosomes,
as
key
mediators
of
intercellular
communication,
have
been
increasingly
recognized
for
their
role
in
the
oncogenic
processes,
particularly
facilitating
drug
resistance.
This
article
delves
into
emerging
evidence
linking
exosomal
lncRNAs
to
modulation
resistance
mechanisms
cancers
such
ovarian,
cervical,
and
endometrial
cancer.
It
synthesizes
current
research
findings
on
how
these
influence
cancer
cell
survival,
tumor
microenvironment,
chemotherapy
efficacy.
Additionally,
review
highlights
potential
therapeutic
strategies
targeting
lncRNAs,
proposing
a
new
frontier
overcoming
By
mapping
interface
resistance,
this
aims
provide
comprehensive
understanding
that
could
pave
way
innovative
treatments
improved
patient
outcomes
female
reproductive
system
cancers.
