Journal of Immunology Research,
Год журнала:
2018,
Номер
2018, С. 1 - 9
Опубликована: Янв. 1, 2018
Macrophages
are
crucial
members
of
the
mononuclear
phagocyte
system
essential
to
protect
host
from
invading
pathogens
and
central
inflammatory
response
with
their
ability
acquire
specialized
phenotypes
(M1)
anti-inflammatory
(M2)
produce
a
pool
mediators.
Equipped
broad
range
receptors,
such
as
Toll-like
receptor
4
(TLR4),
CD14,
Fc
gamma
receptors
(Fc
γ
Rs),
macrophages
can
efficiently
recognize
phagocytize
secrete
cytokines
by
triggering
various
secondary
signaling
pathways.
Phospholipase
C
(PLC)
is
family
enzymes
that
hydrolyze
phospholipids,
most
significant
which
phosphatidylinositol
4,5-bisphosphate
[PI(4,5)P2].
Cleavage
at
internal
phosphate
ester
generates
two
second
messengers,
inositol
1,4,5-trisphosphate
(IP3)
diacylglycerol
(DAG),
both
mediate
in
diverse
cellular
functions
including
response.
Recent
studies
have
shown
some
PLC
isoforms
involved
multiple
stages
TLR4-,
CD14-,
Rs-mediated
activation
nuclear
factor
kappa
B
(NF-
κ
B),
mitogen-activated
protein
kinase
(MAPK),
interferon
regulatory
factors
(IRFs),
all
associated
regulation
Therefore,
implicated
pathogenesis
numerous
diseases.
This
review
provides
an
overview
our
current
knowledge
on
how
regulates
macrophage-mediated
Journal of Immunology Research,
Год журнала:
2017,
Номер
2017, С. 1 - 14
Опубликована: Янв. 1, 2017
Lactobacilli
have
been
shown
to
promote
health
functions.
In
this
study,
we
analyzed
the
mechanism
by
which
four
different
strains
of
probiotics
affected
innate
immunity,
such
as
regulation
ROS,
cytokines,
phagocytosis,
bactericidal
activity,
signaling
NF-κB
pp65,
and
TLR2
activation.
The
production
ROS
was
dependent
on
concentration
species
Lactobacillus.
results
obtained
from
tested
(Lactobacillus
rhamnosus
GG,
L.
KLSD,
helveticus
IMAU70129,
casei
IMAU60214)
showed
that
induced
early
proinflammatory
cytokines
IL-8,TNF-α,
IL-12p70,
IL-6.
However,
IL-1β
expression
only
(after
24
h
stimulation).
Phagocytosis
activity
macrophages
against
various
pathogens,
S.
aureus,
typhimurium,
E.
coli,
were
increased
pretreatment
with
nuclear
translocation
pp65
TLR2-dependent
also
treatment
probiotics.
Taken
together,
experiments
demonstrate
probiotic
Lactobacillus
exert
immunostimulatory
effects
may
be
directly
linked
initial
inflammation
response
human
macrophages.
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Ноя. 24, 2021
Cellular
immunotherapies
represent
a
promising
approach
for
the
treatment
of
cancer.
Engineered
adoptive
cell
therapies
redirect
and
augment
leukocyte’s
inherent
ability
to
mount
an
immune
response
by
introducing
novel
anti-tumor
capabilities
targeting
moieties.
A
prominent
example
this
is
use
T
cells
engineered
express
chimeric
antigen
receptors
(CARs),
which
have
demonstrated
significant
efficacy
against
some
hematologic
malignancies.
Despite
increasingly
sophisticated
strategies
harness
function,
solid
tumors
has
remained
elusive
therapies.
Amongst
types
used
in
immunotherapies,
however,
macrophages
recently
emerged
as
candidates
tumors.
In
review,
we
discuss
monocytes
Macrophages
are
innate
that
intrinsically
equipped
with
broad
therapeutic
effector
functions,
including
active
trafficking
tumor
sites,
direct
phagocytosis,
activation
microenvironment
professional
presentation.
We
focus
on
engineering
manipulating
macrophages,
specific
CAR
(CAR-M).
highlight
design
production
CAR-M
transfer,
clinical
considerations
their
treating
then
outline
recent
progress
results
applying
immunotherapies.
The
development
macrophage-based
holds
promise
key
weapon
therapy
armamentarium.
Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29686 - e29686
Опубликована: Апрель 1, 2024
Monocytes
and
macrophages
are
essential
components
of
innate
immune
system
have
versatile
roles
in
homeostasis
immunity.
These
phenotypically
distinguishable
mononuclear
phagocytes
play
distinct
different
stages,
contributing
to
the
pathophysiology
various
forms
making
them
a
potentially
attractive
therapeutic
target
inflammatory
conditions.
Several
pieces
evidence
supported
role
cell
surface
receptors
expressed
on
these
cells
their
downstream
signaling
molecules
initiating
perpetuating
response.
In
this
review,
we
discuss
current
understanding
monocyte
macrophage
biology
inflammation,
highlighting
chemoattractants,
inflammasomes,
integrins
function
monocytes
during
events
inflammation.
This
review
also
covers
recent
interventions
targeting
at
cellular
molecular
levels.
Theranostics,
Год журнала:
2020,
Номер
11(4), С. 1568 - 1593
Опубликована: Дек. 16, 2020
Macrophages
are
specialized
cells
that
control
tissue
homeostasis.
They
include
non-resident
and
tissue-resident
macrophage
populations
which
characterized
by
the
expression
of
particular
cell
surface
markers
secretion
molecules
with
a
wide
range
biological
functions.
The
differentiation
polarization
macrophages
relies
on
specific
growth
factors
their
receptors.
Macrophage-colony
stimulating
factor
(CSF-1)
interleukine-34
(IL-34),
also
known
as
"twin"
cytokines,
part
this
regluatory
landscape.
CSF-1
IL-34
share
common
receptor,
macrophage-colony
receptor
(CSF-1R),
is
activated
in
similar
way
both
turns
identical
signaling
pathways.
However,
there
some
discrete
differential
activation
leading
to
activities.
In
review,
we
disscuss
recent
progress
understanding
role
twin
cytokines
differentiation,
from
interaction
CSF-1R
pathways,
implication
macrophages.
A
special
focus
IL-34,
its
involvement
pathophsyiological
contexts,
potential
theranostic
target
for
therapy
will
be
proposed.
