Altered perivascular spaces in subcortical white matter in Parkinson’s disease patients with levodopa-induced dyskinesia

npj Parkinson s Disease, Год журнала: 2024, Номер 10(1)

Опубликована: Март 28, 2024

Dilated perivascular spaces (PVS) have emerged as a pathological hallmark in various neurological conditions, including Parkinson's disease (PD). Levodopa-induced dyskinesia (LID), an intractable motor complication of PD, remains enigmatic regarding the distribution patterns PVS. Our objective was to scrutinize percent PVS (pPVS) changes within PD patients with LID (PD-LID). In total, 132 individuals were enrolled, PD-LID (n = 42), without (PD-nLID, n 45), and healthy controls (HCs, 45). Employing automated approach for quantification based on structural magnetic resonance imaging, we comprehensively evaluated total pPVS subcortical white matter globally regionally. A significant increase global observed versus HCs, particularly evident relative HCs. Within group, elevated discerned right inferior frontal gyrus region (rIFG) (pars opercularis), contrasting PD-nLID Moreover, exhibited increased bilateral superior temporal regions compared Notably, rIFG positively correlated dyskinetic symptoms could well identify LID. findings unveiled alternations at both regional levels, highlighting prospective imaging marker

Язык: Английский

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Early detection of dopaminergic dysfunction and glymphatic system impairment in Parkinson's disease

Parkinsonism & Related Disorders, Год журнала: 2024, Номер 127, С. 107089 - 107089

Опубликована: Авг. 3, 2024

Язык: Английский

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Glymphatic system in neurological disorders and implications for brain health

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Keywords: glymphatic system, perivascular space, slow wave sleep, brain health, dementia, CSVD, stroke

Язык: Английский

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Influence of orientation, size and shape of the region of interest in diffusion MRI along perivascular spaces index

Magnetic Resonance Materials in Physics Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Abstract Objective Diffusion-tensor imaging (DTI) and diffusion-weighted (DWI) along perivascular spaces (ALPS) index have been proposed as noninvasive techniques to indirectly evaluate the glymphatic system function. However, these are sensitive examination parameters, limiting inter-study comparability. The definition of region interest (ROI) has identified primary weakness ALPS method. Therefore, we aimed determine which ROI characteristics would best promote consistent analysis. Methods We examined 13 healthy volunteers using DTI DWI calculate index, compared determined correlations among 11 different configurations, tested inter-method reliability. Results found significant differences between configurations in calculation. Considering reliability, a squared is most suitable. ICC showed good-to-excellent agreement (mean = 0.83). did not find differences. Conclusion It important standardize for

Язык: Английский

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Glymphatic Pathway Dysfunction in Severe Obstructive Sleep Apnea: A Meta-Analysis

Sleep Medicine, Год журнала: 2025, Номер 131, С. 106528 - 106528

Опубликована: Апрель 21, 2025

Язык: Английский

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