Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson’s disease DOI Creative Commons

Ruolan Lin,

Guoen Cai, Ying Chen

et al.

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 28, 2025

Growing evidence highlights the roles of glymphatic system and peripheral inflammation in Parkinson's disease (PD). We evaluated their interrelationship potential mechanisms contributing to motor symptoms using DTI-ALPS inflammatory markers (leukocyte, lymphocyte, neutrophil counts, neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte [PLR]) 134 PD patients (52 tremor-dominant [TD], 62 postural instability gait difficulty [PIGD]) 81 healthy controls (HC, 33 with markers). exhibited lower than HC (1.43 ± 0.19 vs. 1.52 0.21, p = 0.001). was negatively correlated NLR, PLR, neutrophils (all < 0.05) PIGD (β –0.043, 0.048), positively lymphocytes TD 0.105, 0.034). mediated relationship between (NLR neutrophils) MDS-UPDRS III score PD. Overall, dysfunction correlates may mediate effects on PD, distinct profiles PIGD.

Language: Английский

Glymphatic system in neurological disorders and implications for brain health DOI Creative Commons
Osman Corbali, Allan I. Levey

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Keywords: glymphatic system, perivascular space, slow wave sleep, brain health, dementia, CSVD, stroke

Language: Английский

Citations

0
MRI‐based surrogates of brain clearance in narcolepsy type 1 DOI Creative Commons
Eva M. van Heese, Jari K. Gool, Gert Jan Lammers

et al.

Journal of Sleep Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Summary Brain clearance involves the drainage of waste molecules from brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt approximate human brain with surrogate measures. The current study aimed explore whether two surrogates are altered in narcolepsy. We processed diffusion‐weighted and functional resting‐state images extract surrogates: Diffusion Tensor Imaging Along Perivascular Space (DTI‐ALPS index), dBOLD‐CSF coupling. Both measures were analysed 12 drug‐free, awake people narcolepsy type 1 11 age‐ sex‐matched controls, as well relation clinical features. also assessed correlation between DTI‐ALPS index coupling amplitude did not show significant differences nor relations severity excessive daytime sleepiness. found sleep efficiency, hypothesis supported by evidence study. correlated each other, suggesting both offer different perspectives same underlying physiology. Yet, suitability markers remains debatable. Whereas DTI exclusively sensitive perivascular fluid, reflecting large‐scale CSF motion. Future work should other markers, preferably sleep, better understand possible role symptomatology.

Language: Английский

Citations

0
Increased glymphatic system activity and thalamic vulnerability in drug-naive somatic depression: Evidenced by DTI-ALPS index DOI Creative Commons
Zipeng Deng, Wei Wang,

Zhaowen Nie

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103769 - 103769

Published: March 1, 2025

Language: Английский

Citations

0
Sleep disturbances are related to glymphatic dysfunction in blepharospasm DOI

Zhengkun Yang,

Shuai Gong,

Jiana Zhang

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson’s disease DOI Creative Commons

Ruolan Lin,

Guoen Cai, Ying Chen

et al.

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 28, 2025

Growing evidence highlights the roles of glymphatic system and peripheral inflammation in Parkinson's disease (PD). We evaluated their interrelationship potential mechanisms contributing to motor symptoms using DTI-ALPS inflammatory markers (leukocyte, lymphocyte, neutrophil counts, neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte [PLR]) 134 PD patients (52 tremor-dominant [TD], 62 postural instability gait difficulty [PIGD]) 81 healthy controls (HC, 33 with markers). exhibited lower than HC (1.43 ± 0.19 vs. 1.52 0.21, p = 0.001). was negatively correlated NLR, PLR, neutrophils (all < 0.05) PIGD (β –0.043, 0.048), positively lymphocytes TD 0.105, 0.034). mediated relationship between (NLR neutrophils) MDS-UPDRS III score PD. Overall, dysfunction correlates may mediate effects on PD, distinct profiles PIGD.

Language: Английский

Citations

0