Late neurological consequences of SARS-CoV-2 infection: New challenges for the neurologist

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Фев. 9, 2023

In this study, a systematic review of the literature was performed to study frequency neurological symptoms and diseases in adult patients with COVID-19 that may be late consequences SARS-CoV-2 infection.Relevant studies were identified through electronic explorations Scopus, PubMed, Google Scholar. We followed PRISMA guidelines. Data collected from where diagnosis confirmed its occurred at least 4 weeks after initial infection. Review articles excluded study. Neurological manifestations stratified based on (above 5, 10, 20%), number sample size significant.A total 497 for eligible content. This article provides relevant information 45 involving 9,746 patients. Fatigue, cognitive problems, smell taste dysfunctions most frequently reported long-term COVID-19. Other common issues paresthesia, headache, dizziness.On global scale affected COVID-19, prolonged problems have become increasingly recognized concerning. Our might an additional source knowledge about potential impacts.

Язык: Английский

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Cognitive Aspects of COVID-19

Current Neurology and Neuroscience Reports, Год журнала: 2023, Номер 23(9), С. 531 - 538

Опубликована: Июль 25, 2023

Язык: Английский

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Persistent post–COVID‐19 neuromuscular symptoms

Muscle & Nerve, Год журнала: 2023, Номер 68(4), С. 350 - 355

Опубликована: Июль 19, 2023

Abstract Neuromuscular symptoms may develop or persist after resolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Besides residual sensorimotor associated with neuromuscular complications disease‐2019 (COVID‐19), such as Guillain–Barré syndrome, critical illness neuromyopathy, and rhabdomyolysis, patients report persistent autonomic symptoms, sensory muscle in the absence these complications, including palpitations, orthostatic dizziness intolerance, paresthesia, myalgia, fatigue. These be long COVID, also known post–COVID‐19 conditions postacute sequelae SARS‐CoV‐2 infection, which significantly impact quality life. Managing represents a challenge for health‐care providers. Recent advances have identified small‐fiber neuropathy potential etiology that underlie dysfunction paresthesia some COVID patients. The pathogenic mechanisms underlying myalgia fatigue remain elusive need to investigated. Herein we review current state knowledge regarding evaluation management symptoms.

Язык: Английский

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COVID-19 and Alzheimer’s Disease Share Common Neurological and Ophthalmological Manifestations: A Bidirectional Risk in the Post-Pandemic Future

Cells, Год журнала: 2023, Номер 12(22), С. 2601 - 2601

Опубликована: Ноя. 10, 2023

A growing body of evidence indicates that a neuropathological cross-talk takes place between the coronavirus disease 2019 (COVID-19) -the pandemic severe pneumonia has had tremendous impact on global economy and health since three years after its outbreak in December 2019- Alzheimer’s Disease (AD), leading cause dementia among human beings, reaching 139 million by year 2050. Even though COVID-19 is primary respiratory disease, causative agent, so-called Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), also endowed with high neuro-invasive potential (Neurocovid). The neurological complications COVID-19, resulting from direct viral entry into Central Nervous System (CNS) and/or indirect systemic inflammation dysregulated activation immune response, encompass memory decline anosmia which are typically associated AD symptomatology. In addition, patients diagnosed more vulnerable to SARS-CoV-2 infection inclined clinical outcomes. present review, we better elucidate intimate connection summarizing involved risk factors/targets underlying biological mechanisms shared these two disorders particular focus Angiotensin-Converting Enzyme (ACE2) receptor, APOlipoprotein E (APOE), aging, neuroinflammation cellular pathways Amyloid Precursor Protein (APP)/Amyloid beta (Aβ) tau neuropathologies. Finally, involvement ophthalmological manifestations, including vitreo-retinal abnormalities visual deficits, both discussed. Understanding common physiopathological aspects linking will pave way novel management diagnostic/therapeutic approaches cope them post-pandemic future.

Язык: Английский

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Post-traumatic stress disorder during the Covid-19 pandemic: a national, population-representative, longitudinal study of U.S. adults

npj Mental Health Research, Год журнала: 2024, Номер 3(1)

Опубликована: Апрель 10, 2024

Abstract Substantial literature documents the impact of mass traumatic events on post-traumatic stress disorder (PTSD) in populations. However, trajectory PTSD US population during pandemic and association between assets, Covid-19 related stressors, over time remains unclear. The Life Stressors Impact Mental Health Well-Being (CLIMB) is a nationally representative, longitudinal panel adults Spring 2020 ( N = 1270), 2021 1182), 2022 1091). Using four-item PC-PTSD-4, we assessed prevalence probable three years. generalized estimating equations (GEE) logistic regression at each wave, estimated associations demographics, stressors with PTSD. Here report that overall decreases from 22.2% to 16.8% p 0.02). Persons household incomes below $20,000 higher compared other income groups. GEE model shows odds among persons (OR 2.17 (95%CI: 1.35,3.50)) relative $75,000 or more; high stressor scores 2.33 1.72,3.15)) low scores. High are associated 2.69 1.56,4.66)), 4.58 2.52,8.30)), 3.89 2.05,7.38)) This analysis highlights pandemic’s prolonged influence mental health, particularly fewer economic assets those experiencing more pandemic-related stressors. Reducing health disparities requires interventions address inequities.

Язык: Английский

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