Diabetes Care,
Год журнала:
2022,
Номер
45(11), С. 2746 - 2748
Опубликована: Сен. 12, 2022
OBJECTIVE
We
investigated
endotrophin,
a
profibrotic
signaling
molecule
reflecting
collagen
VI
formation,
in
serum
and
urine
as
risk
marker
for
complications
to
type
2
diabetes.
RESEARCH
DESIGN
AND
METHODS
Endotrophin
was
measured
774
individuals
with
Outcomes
included
composite
kidney
end
point,
first
major
adverse
cardiovascular
event
(MACE),
mortality,
progression
of
albuminuria,
incident
heart
failure,
sight-threatening
eye
disease.
Adjusted
Cox
proportional
hazards
models
were
applied.
RESULTS
Doubling
endotrophin
associated
the
point
(n
=
49;
hazard
ratio
1.80
[95%
CI
1.13–2.87]),
MACE
66;
1.54
[1.04–2.28]),
mortality
156;
1.69
(1.31–2.19]),
failure
42;
1.63
[1.02–2.60]).
A
doubling
albuminuria
85;
1.20
[1.04–1.39]).
CONCLUSIONS
Serum
Urine
progression.
Cancers,
Год журнала:
2022,
Номер
14(1), С. 238 - 238
Опубликована: Янв. 4, 2022
The
extracellular
matrix
(ECM)
is
highly
dynamic
as
it
constantly
deposited,
remodeled
and
degraded
to
maintain
tissue
homeostasis.
ECM
a
major
structural
component
of
the
tumor
microenvironment,
cancer
development
progression
require
its
extensive
reorganization.
Cancerized
biochemically
different
in
composition
stiffer
compared
normal
ECM.
abnormal
affects
by
directly
promoting
cell
proliferation,
survival,
migration
differentiation.
restructured
degradation
fragments
(matrikines)
also
modulate
signaling
cascades
mediated
interaction
with
cell-surface
receptors,
deregulate
stromal
behavior
lead
emergence
an
oncogenic
microenvironment.
Here,
we
summarize
current
state
understanding
how
structure
changes
during
progression.
We
describe
functional
role
key
proteins,
especially
tenascin
C
fibronectin,
molecules
involved
formation
well
pathways
that
they
activate
cells.
Molecules,
Год журнала:
2024,
Номер
29(7), С. 1417 - 1417
Опубликована: Март 22, 2024
Collagens
are
fundamental
constituents
of
the
extracellular
matrix
and
most
abundant
proteins
in
mammals.
belong
to
family
fibrous
or
fiber-forming
that
self-assemble
into
fibrils
define
their
mechanical
properties
biological
functions.
Up
now,
28
members
collagen
superfamily
have
been
recognized.
Collagen
biosynthesis
occurs
endoplasmic
reticulum,
where
specific
post-translational
modification—glycosylation—is
also
carried
out.
The
glycosylation
collagens
is
very
adds
β-d-galactopyranose
β-d-Glcp-(1→2)-d-Galp
disaccharide
through
β-O-linkage
hydroxylysine.
Several
glycosyltransferases,
namely
COLGALT1,
COLGALT2,
LH3,
PGGHG
glucosidase,
were
associated
with
collagens,
recently,
crystal
structure
LH3
has
solved.
Although
not
fully
understood,
it
clear
influences
secretion
alignment
fibrils.
A
growing
body
evidence
associates
its
functions
various
human
diseases.
Recent
progress
understanding
allows
for
exploitation
therapeutic
potential
discovery
new
agents.
This
review
will
discuss
relevant
contributions
collagens.
Then,
glycosyltransferases
involved
glycosylation,
structure,
catalytic
mechanism
be
surveyed.
Furthermore,
involvement
glycosylation-related
diseases
discussed.
Biomedicines,
Год журнала:
2023,
Номер
11(5), С. 1412 - 1412
Опубликована: Май 10, 2023
The
globally
increasing
prevalence
of
obesity
is
associated
with
the
development
metabolic
diseases
such
as
type
2
diabetes,
dyslipidemia,
and
fatty
liver.
Excess
adipose
tissue
(AT)
often
leads
to
its
malfunction
a
systemic
dysfunction
because,
in
addition
storing
lipids,
AT
an
active
endocrine
system.
Adipocytes
are
embedded
unique
extracellular
matrix
(ECM),
which
provides
structural
support
cells
well
participating
regulation
their
functions,
proliferation
differentiation.
have
thin
pericellular
layer
specialized
ECM,
referred
basement
membrane
(BM),
important
functional
unit
that
lies
between
stroma.
Collagens
form
major
group
proteins
some
them,
especially
BM-associated
collagens,
functions
participate
adipocyte
In
pathological
conditions
obesity,
proceeds
fibrosis,
characterized
by
accumulation
large
collagen
bundles,
disturbs
natural
AT.
this
review,
we
summarize
current
knowledge
on
vertebrate
collagens
for
function
include
basic
information
other
ECM
components,
principally
fibronectin,
We
also
briefly
discuss
certain
they
been
shown
play
central
roles.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 15, 2024
This
review
explores
the
mechanisms
of
chronic
radiation-induced
skin
injury
fibrosis,
focusing
on
transition
from
acute
radiation
damage
to
a
fibrotic
state.
It
reviewed
cellular
and
molecular
responses
radiation,
highlighting
role
myofibroblasts
significant
impact
Transforming
Growth
Factor-beta
(TGF-β)
in
promoting
fibroblast-to-myofibroblast
transformation.
The
delves
into
epigenetic
regulation
gene
expression,
contribution
extracellular
matrix
proteins
microenvironment,
immune
system
context
fibrosis.
Additionally,
it
discusses
potential
biomaterials
artificial
intelligence
medical
research
advance
understanding
treatment
suggesting
future
directions
involving
bioinformatics
personalized
therapeutic
strategies
enhance
patient
quality
life.
Diabetes,
Год журнала:
2024,
Номер
73(4), С. 618 - 627
Опубликована: Янв. 11, 2024
At
present,
safe
and
effective
treatment
drugs
are
urgently
needed
for
diabetic
kidney
disease
(DKD).
Circulating
protein
biomarkers
with
causal
genetic
evidence
represent
promising
drug
targets,
which
provides
an
opportunity
to
identify
new
therapeutic
targets.
Summary
data
from
two
quantitative
trait
loci
studies
presented,
one
involving
4,907
plasma
proteins
35,559
individuals
the
other
encompassing
4,657
among
7,213
European
Americans.
statistics
DKD
were
obtained
a
large
genome-wide
association
study
(3,345
cases
2,372
controls)
FinnGen
(3,676
283,456
controls).
Mendelian
randomization
(MR)
analysis
was
conducted
examine
potential
targets
DKD.
The
colocalization
used
detect
whether
exist
in
shared
variants.
To
enhance
credibility
of
results,
external
validation
conducted.
Additionally,
enrichment
analysis,
assessment
druggability,
protein-protein
interaction
networks
further
enrich
research
findings.
proteome-wide
MR
analyses
identified
21
blood
that
may
causally
be
associated
Colocalization
supported
relationship
between
12
DKD,
confirming
4
these
proteins,
TGFBI
affirmed
through
separate
group
sets.
These
results
indicate
targeting
four
could
approach
treating
warrant
clinical
investigations.
Article
Highlights
Abstract
Obesity
strongly
increases
the
risk
of
cardiometabolic
diseases,
yet
underlying
mediators
this
relationship
are
not
fully
understood.
Given
that
obesity
influences
circulating
protein
levels,
we
investigated
proteins
mediating
effects
on
coronary
artery
disease,
stroke
and
type
2
diabetes.
By
integrating
two-step
proteome-wide
Mendelian
randomization,
colocalization,
epigenomics
single-cell
RNA
sequencing,
identified
five
prioritized
collagen
VI
α3
(COL6A3).
COL6A3
levels
were
increased
by
body
mass
index
disease
risk.
Notably,
carboxyl
terminus
product
COL6A3,
endotrophin,
drove
effect.
was
highly
expressed
in
disease-relevant
cell
types
tissues.
Finally,
found
fat
reduction
could
reduce
plasma
COL6A3-derived
indicating
a
tractable
way
to
modify
endotrophin
levels.
In
summary,
provide
actionable
insights
into
how
mediate
diseases
prioritize
as
potential
therapeutic
target.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2963 - 2963
Опубликована: Фев. 3, 2023
Systemic
sclerosis
(SSc),
also
known
as
scleroderma,
is
an
autoimmune
disorder
that
affects
the
connective
tissues
and
has
highest
mortality
rate
among
rheumatic
diseases.
One
of
hallmarks
SSc
fibrosis,
which
may
develop
systemically,
affecting
skin
virtually
any
visceral
organ
in
body.
Fibrosis
lungs
leads
to
interstitial
lung
disease
(ILD),
currently
leading
cause
death
SSc.
The
identification
effective
treatments
stop
or
reverse
fibrosis
been
main
challenge
reducing
improving
patient
outcomes
quality
life.
Thus,
understanding
molecular
mechanisms,
altered
pathways,
their
potential
interactions
key
developing
therapies.
In
this
review,
we
discuss
diverse
mechanisms
involved
SSc-related
provide
insights
into
homeostasis
state
inherent
fatal
complication.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 16, 2025
Type
2
diabetes
mellitus-related
sarcopenia
(T2DMRS)
is
a
common
complication
in
elderly
and
advanced
patients
that
affects
long-term
prognosis
quality
of
life.
Skeletal
muscle
the
main
unit
glucose
metabolism,
it
surrounded
by
extracellular
matrix
(ECM),
which
microenvironment
acts
as
an
efficient
highway
system.
The
ECM
essential
for
cellular
communication
nutrient
transport
supports
cell
growth
repair.
When
this
"ECM
highway"
fails
to
function
effectively
because
damage
or
blockage,
development
T2DMRS
can
be
triggered
exacerbated.
In
recent
years,
has
been
widely
demonstrated
play
critical
role
insulin
resistance
skeletal
regeneration.
However,
how
remodeling
components
specifically
mechanism
action
not
scientifically
described
detail.
review,
we
comprehensively
summarize
T2DMRS-related
mechanisms
remodeling,
suggesting
collagen
integrins
may
potential
therapeutic
targets.
