This
study
aimed
to
elucidate
the
pathogenesis
of
idiopathic
gingival
fibromatosis
(IGF).
Human
fibroblasts
(hGFs)
were
isolated
from
patients
with
IGF
and
periodontitis.
Differential
gene
expression
in
hGFs
was
analyzed
using
RNA
sequencing.
Extracellular
matrix-related
analyzed.
The
effect
specific
protein
(SP)1
inhibitor
or
recombinant
human
transglutaminase
2
(rh-TGM2)
on
biglycan
(BGN)
also
determined.
sequencing
showed
that
TGM2
downregulated
BGN
mRNA
upregulated
relative
rh-TGM2
stimulation
significantly
reduced
expression.
SP1
inhibitors
hGFs.
upregulation
via
causes
downregulation
IGF.
Biomolecules,
Год журнала:
2024,
Номер
14(9), С. 1186 - 1186
Опубликована: Сен. 20, 2024
Glycosaminoglycans
(GAGs)
and
proteoglycans
(PGs)
are
essential
components
of
the
extracellular
matrix
(ECM)
with
pivotal
roles
in
cellular
mechanosensing
pathways.
GAGs,
such
as
heparan
sulfate
(HS)
chondroitin
(CS),
interact
various
cell
surface
receptors,
including
integrins
receptor
tyrosine
kinases,
to
modulate
responses
mechanical
stimuli.
PGs,
comprising
a
core
protein
covalently
attached
GAG
chains,
serve
dynamic
regulators
tissue
mechanics
behavior,
thereby
playing
crucial
role
maintaining
homeostasis.
Dysregulation
GAG/PG-mediated
pathways
is
implicated
numerous
pathological
conditions,
cancer
inflammation.
Understanding
intricate
mechanisms
by
which
GAGs
PGs
forces
holds
promise
for
developing
novel
therapeutic
strategies
targeting
mechanotransduction
disease.
This
comprehensive
overview
underscores
importance
key
mediators
homeostasis
their
potential
targets
mitigating
mechano-driven
pathologies,
focusing
on
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1256 - 1256
Опубликована: Янв. 31, 2025
Normal
development
of
joints
starts
in
utero
with
the
establishment
a
cellular
and
extracellular
matrix
template.
Following
birth,
individual
joint
tissues
grow
mature
response
to
biochemical
mechanical
signals,
leading
coordinated
pattern
further
maturation
resulting
that
functions
as
an
organ
system.
Each
develops
matures
system
defined
by
biomechanical
environment
which
it
will
function.
For
those
hypermobility
syndromes,
either
specific
genetic
mutations
or
not
(i.e.,
Ehlers–Danlos
syndrome,
Marfan
Loey–Dietz
hypermobility-type
syndrome),
this
process
is
partially
compromised,
but
many
aspects
tissue
function
retained
such
organs
form
retain
partial
function,
compromised.
Comparing
characteristics
what
known
regarding
development,
growth,
maturation,
stressors
puberty,
pregnancy,
aging
without
leads
conclusion
have
systems
may
be
compromised
via
failure
undergo
possibly
defective
mechanotransduction.
Given
breadth
involved
characterization
concept
reveal
commonalities
their
impact
on
inform
regulatory
normal
functional
integrity.
This
review/perspective
piece
attempt
detail
comparisons
summarize
how
study
aid
understanding.
Cells,
Год журнала:
2024,
Номер
13(14), С. 1203 - 1203
Опубликована: Июль 16, 2024
Hyaluronan
(HA)
is
a
large
polysaccharide
that
broadly
distributed
and
highly
abundant
in
the
soft
connective
tissues
embryos
of
vertebrates.
The
constitutive
turnover
HA
very
high,
estimated
at
5
g
per
day
an
average
(70
kg)
adult
human,
but
must
also
be
tightly
regulated
some
processes.
Six
genes
encoding
homologues
to
bee
venom
hyaluronidase
(
Carbohydrate Polymers,
Год журнала:
2024,
Номер
341, С. 122294 - 122294
Опубликована: Май 24, 2024
The
role
of
glycosaminoglycans
(GAGs)
in
modulating
bone
morphogenetic
protein
(BMP)
signaling
represents
a
recent
and
underexplored
area.
Conflicting
reports
suggest
dual
effect:
some
indicate
positive
influence,
while
others
demonstrate
negative
impact.
This
duality
suggests
that
the
localization
GAGs
(either
at
cell
surface
or
within
extracellular
matrix)
specific
type
GAG
may
dictate
their
role.
precise
sulfation
patterns
heparan
sulfate
(HS)
responsible
for
BMP2
binding
remain
elusive.
exhibits
preference
to
HS
over
other
GAGs.
Using
well-characterized
biomaterials
mimicking
matrix,
our
research
reveals
promotes
space,
contrary
chondroitin
(CS),
which
enhances
bioactivity
surface.
Further
observations
central
IdoA
(2S)-GlcNS
(6S)
tri-sulfated
motif
hexasaccharides
binding.
Nevertheless,
degree
adaptability
various
types
sequences.
Molecular
dynamic
simulations
attribute
this
N-terminal
end
flexibility.
Our
findings
illustrate
complex
interplay
between
BMP
signaling,
highlighting
importance
patterns.
understanding
has
implications
development
with
tailored
properties
therapeutic
applications
targeting
pathways.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 10891 - 10891
Опубликована: Окт. 10, 2024
Since
its
introduction,
the
number
of
heart
surgeries
has
risen
continuously.
It
is
a
high-risk
procedure,
usually
involving
cardiopulmonary
bypass,
which
associated
with
an
inflammatory
reaction
that
can
lead
to
perioperative
and
postoperative
organ
dysfunction.
The
extent
complications
following
cardiac
surgery
been
focus
interest
for
several
years
because
their
impact
on
patient
outcomes.
Recently,
numerous
scientific
efforts
have
made
uncover
complex
mechanisms
interaction
between
inflammation,
oxidative
stress,
endothelial
dysfunction
occur
after
surgery.
Numerous
factors,
such
as
surgical
anesthetic
techniques,
hypervolemia
hypovolemia,
hypothermia,
various
drugs
used
during
trigger
development
systemic
response
release
species.
They
affect
endothelium,
especially
glycocalyx
(EG),
thin
surface
layer
responsible
vascular
hemostasis,
permeability
leukocytes
endothelium.
This
review
highlights
current
knowledge
molecular
involved
in
dysfunction,
particularly
degradation
EG.
In
addition,
major
events
stress
responses
surgery,
EG,
clinical
implications
these
summarized
discussed
detail.
A
better
understanding
underlying
leading
needed
improve
management
develop
effective
strategies
prevent
adverse
outcomes
complicate
recovery.
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
Glycosaminoglycans
(GAGs)
play
a
pivotal
role
in
pathogen
attachment
and
entry
into
host
cells,
where
the
interaction
with
GAGs
is
critical
for
diverse
range
of
bacteria
viruses.
This
study
focuses
on
elucidating
specific
interactions
between
sulfated
adhesin
OmcB
(Outer
membrane
complex
protein
B)
Chlamydia
species,
examining
how
structural
characteristics
GAGs,
such
as
sulfation
degree
molecular
weight,
influence
their
binding
affinity
thereby
affect
bacterial
infectivity.
A
surface‐based
assay
established
to
determine
constants
various
GAGs.
It
shown
that
increased
higher
weight
enhance
GAG
OmcB.
These
findings
are
further
validated
using
cell
assays,
which
shows
addition
reduces
OmcB‐cell
inhibits
C.
pneumoniae
elementary
bodies
(EBs),
underscoring
chlamydial
infections.
Notably,
heparin
exhibites
stronger
inhibitory
effect
compare
similar
degrees
weights,
suggesting
particular
architectures
may
optimize
interactions.
