Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 29, 2025
This
study
aims
to
analyze
global
trends
in
smoking-attributable
peptic
ulcer
disease
(PUD)
disability-adjusted
life
years
(DALYs)
from
1990
2021
and
project
future
2046.
Data
were
obtained
the
Global
Burden
of
Disease
Study
2021.
We
calculated
age-standardized
DALYs
rates
(ASDR)
estimated
annual
percentage
changes
(EAPC)
for
PUD
DALYs.
Bayesian
Age-Period-Cohort
models
used
trends.
From
2021,
decreased
significantly,
with
rate
declining
35.4
9.4
per
100,000
(EAPC:
-4.45%).
High-income
regions
showed
faster
declines,
while
some
low-
middle-income
countries
experienced
slower
progress
or
even
increases.
Gender
disparities
observed,
males
consistently
showing
higher
ASDR.
Projections
suggest
a
continued
decline
2046,
persistent
regional
disparities.
By
ASDR
is
expected
decrease
approximately
3.2
100,000,
persisting
certain
such
as
Kiribati
(44.6
100,000)
Cambodia
(45.1
100,000).
While
have
significantly
are
projected
continue
declining,
substantial
gender
persist.
These
findings
underscore
need
targeted
tobacco
control
interventions,
particularly
high-risk
among
vulnerable
populations,
further
reduce
burden
PUD.
Diagnostics,
Год журнала:
2022,
Номер
12(2), С. 508 - 508
Опубликована: Фев. 16, 2022
Rapid
diagnosis
and
treatment
application
in
the
early
stages
of
H.
pylori
infection
plays
an
important
part
inhibiting
transmission
this
as
bacterium
is
involved
various
gastric
pathologies
such
gastritis,
gastro-duodenal
ulcer,
even
neoplasia.
This
review
devoted
to
a
quick
overview
conventional
advanced
detection
techniques
successfully
applied
context
compelling
need
upgrade
standards
diagnostic
methods
which
are
currently
being
used.
Selecting
best
method
implies
evaluating
different
features,
use
one
or
another
test
depending
on
accessibility,
laboratories
equipment,
clinical
conditions
patients.
paper
aims
expose
for
that
available,
highlighting
their
assets
limitations.
The
perspectives
advantages
nanotechnology
along
with
concept
nano(bio)sensors
development
lab-on-chip
devices
tools
detection,
differentiation,
discrimination
also
presented,
by
emphasizing
multiple
advantages:
simple,
fast,
cost-effective,
portable,
miniaturized,
small
volume
samples
required,
highly
sensitive,
selective.
It
generally
accepted
intelligent
sensors
will
completely
revolutionize
acquisition
procedure
medical
decision
framework
smart
healthcare
monitoring
systems.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Апрель 14, 2023
Gastric
cancer
(GC),
a
common
and
high-mortality
disease,
still
occupies
an
important
position
in
current
research,
Helicobacter
pylori
(
H.
)
infection
as
its
risk
factor
has
been
hot
challenging
research
area.
Among
the
numerous
pathogenic
factors
of
,
virulence
protein
CagA
widely
studied
only
bacterial-derived
oncoprotein.
It
was
found
that
entering
into
gastric
epithelial
cells
(GECs)
can
induce
dysregulation
multiple
cellular
pathways
such
MAPK
signaling
pathway,
PI3K/Akt
NF-κB
Wnt/β-catenin
JAK-STAT
Hippo
pathway
through
phosphorylation
non-phosphorylation.
These
disordered
cause
pathological
changes
morphology,
adhesion,
polarity,
proliferation,
movement,
other
processes
GECs,
which
eventually
promotes
occurrence
GC.
With
deepening
-related
on
CagA-induced
abnormal
updated
deepened
to
some
extent,
so
key
activated
by
are
used
main
stem
sort
out
pathogenesis
this
paper,
aiming
provide
new
strategies
for
treatment
GC
future.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(10), С. 8542 - 8542
Опубликована: Май 10, 2023
Outer
membrane
vesicles
(OMVs)
are
lipid-membrane-bounded
nanoparticles
that
released
from
Gram-negative
bacteria
via
vesiculation
of
the
outer
membrane.
They
have
vital
roles
in
different
biological
processes
and
recently,
they
received
increasing
attention
as
possible
candidates
for
a
broad
variety
biomedical
applications.
In
particular,
OMVs
several
characteristics
enable
them
to
be
promising
immune
modulation
against
pathogens,
such
their
ability
induce
host
responses
given
resemblance
parental
bacterial
cell.
Helicobacter
pylori
(H.
pylori)
is
common
bacterium
infects
half
world's
population
causes
gastrointestinal
diseases
peptic
ulcer,
gastritis,
gastric
lymphoma,
carcinoma.
The
current
H.
treatment/prevention
regimens
poorly
effective
limited
success.
This
review
explores
status
future
prospects
biomedicine
with
special
focus
on
use
potential
candidate
its
associated
diseases.
emerging
strategies
can
used
design
viable
immunogenic
discussed.
Pathogens,
Год журнала:
2020,
Номер
9(12), С. 1062 - 1062
Опубликована: Дек. 18, 2020
Helicobacter
pylori
is
a
bacterium
that
capable
of
colonizing
host
for
many
years,
often
lifetime.
The
survival
in
the
gastric
environment
enabled
by
production
numerous
virulence
factors
conditioning
adhesion
to
mucosa
surface,
acquisition
nutrients,
and
neutralization
immune
system
activity.
It
increasingly
recognized,
however,
adaptive
mechanisms
H.
stomach
may
also
be
linked
ability
this
pathogen
form
biofilms.
Initially,
biofilms
produced
were
strongly
associated
scientists
with
water
distribution
systems
considered
as
mechanism
outside
source
fecal-oral
infections.
In
course
last
20
trend
has
changed
now
most
attention
focused
on
biomedical
aspect
structure
its
potential
contribution
therapeutic
difficulties
pylori.
Taking
into
account
fact,
aim
current
review
discuss
phenomenon
biofilm
formation
present
resultant
responses
pylori,
including
morphological
transformation,
membrane
vesicles
secretion,
matrix
production,
efflux
pump
activity,
intermicrobial
communication.
These
will
context
transcriptomic
proteomic
changes
their
modulating
effect
development
complex
structure.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(3), С. 1406 - 1406
Опубликована: Янв. 30, 2021
Helicobacter
pylori
(H.
pylori)
remains
the
most-researched
etiological
factor
for
gastric
inflammation
and
malignancies.
Its
evolution
towards
complications
is
dependent
upon
host
immune
response.
Toll-like
receptors
(TLRs)
recognize
surface
molecular
patterns
of
bacterium,
especially
lipopolysaccharide
(LPS),
act
pathways,
which
will
finally
lead
to
activation
nuclear
factor-kappa
B
(NF-kB),
a
transcription
that
stimulates
release
inflammatory
cytokines.
MicroRNAs
(MiRNAs)
finely
modulate
TLR
signaling,
but
their
expression
also
modulated
by
NF-kB-dependent
pathways.
This
review
aims
focus
several
most
researched
miRNAs
on
this
subject,
with
known
implications
in
responses
caused
H.
pylori,
including
let-7
family,
miRNA-155,
miRNA-146,
miRNA-125,
miRNA-21,
miRNA-221.
TLR–LPS
interactions
afferent
pathways
are
regulated
these
miRNAs,
can
be
considered
as
bridge,
connects
pre-neoplastic
malignant
lesions.
Therefore,
they
could
serve
potential
non-invasive
biomarkers,
capable
discriminating
infection,
well
its
associated
complications.
Given
data
matter
limited
children,
significant
number
future
research
has
yet
clarify
exact
involvement
entities
progression
pylori-associated
conditions.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Март 25, 2022
It
is
widely
accepted
that
production
of
biofilm
a
protective
mechanism
against
various
type
stressors,
including
exposure
to
antibiotics.
However,
the
impact
this
structure
on
spread
antibiotic
resistance
in
Helicobacter
pylori
still
poorly
understood.
Therefore,
aim
current
research
was
determine
relationship
between
formation
and
H.
.
The
study
carried
out
24
clinical
strains
with
different
profiles
(antibiotic-sensitive,
mono-resistant,
double-resistant
multidrug-resistant)
clarithromycin
(CLR),
metronidazole
(MTZ)
levofloxacin
(LEV).
Using
static
conditions
crystal
violet
staining
method,
strong
correlation
observed
CLR
but
not
MTZ
or
LEV.
Based
obtained
results,
three
strongest
weakest
producers
were
selected
directed
for
set
microfluidic
experiments
performed
Bioflux
system
combined
fluorescence
microscopy.
Under
continuous
flow
conditions,
it
formed
twice
as
much
created
significantly
more
eDNA
particular
proteins
within
matrix
when
compared
weak
producers.
Additionally,
noticed
had
higher
tendency
autoaggregation
presented
morphostructural
differences
(a
greater
cellular
packing,
shorter
cells
amount
both
OMVs
flagella)
relation
counterparts.
In
conclusion,
associated
broad
array
phenotypical
features
translating
ability
formation.
Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(17), С. 5086 - 5086
Опубликована: Авг. 30, 2022
Helicobacter
pylori
(Hp)
is
a
prevalent
organism
infecting
almost
half
the
global
population.
It
significant
concern,
given
its
associated
risk
of
gastric
cancer,
which
third
leading
cause
cancer
death
globally.
Infection
can
be
asymptomatic
or
present
with
dyspeptic
symptoms.
may
also
alarm
symptoms
in
case
progression
to
cancer.
Diagnosis
achieved
non-invasively
(breath
tests,
stool
studies,
serology)
invasively
(rapid
urease
test,
biopsy,
culture).
Treatment
involves
acid
suppression
and
regimens
containing
several
antibiotics
guided
by
resistance
rates.
Eradication
essential,
as
it
lowers
complications
Follow-up
after
eradication
similarly
important,
remains.
There
have
been
many
recent
advances
both
diagnosis
treatment
Hp.
In
particular,
biosensors
effective
diagnostic
tools,
nanotechnology,
vaccines,
potassium-competitive
blockers
prove
enhancing
Children,
Год журнала:
2022,
Номер
9(7), С. 994 - 994
Опубликована: Июль 1, 2022
Helicobacter
pylori
(H.
pylori)
is
the
most
common
bacterial
infection
worldwide,
usually
acquired
during
childhood
and
related
to
gastric
carcinogenesis
adulthood.
Therefore,
its
early
proper
diagnosis
subsequent
successful
eradication
represent
cornerstones
of
cancer
prevention.
The
aim
this
narrative
review
was
assess
traditional
modern
diagnostic
methods
in
terms
H.
diagnosis.
Several
invasive
non-invasive
were
described,
each
with
pros
cons.
comprise
endoscopy
biopsy,
rapid
urease
tests,
histopathological
exams,
cultures
biopsy-based
molecular
tests.
Among
these,
probably
available,
accurate
cost-effective
test
remains
histology,
albeit
tests
definitely
remain
despite
their
high
costs.
consist
urea
breath
serology,
stool
antigens
Urea
are
useful
clinical
practice
both
for
monitoring
after
therapy.
challenges
lead
a
choice
that
must
be
based
on
virulence,
environmental
factors
host
peculiarities.