Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Cell Death and Differentiation, Год журнала: 2018, Номер 25(3), С. 486 - 541

Опубликована: Янв. 23, 2018

Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.

Язык: Английский

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Nature, Год журнала: 2015, Номер 526(7575), С. 660 - 665

Опубликована: Сен. 16, 2015

Язык: Английский

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Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Trends in Biochemical Sciences, Год журнала: 2016, Номер 42(4), С. 245 - 254

Опубликована: Дек. 5, 2016

Язык: Английский

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Nature, Год журнала: 2017, Номер 547(7661), С. 99 - 103

Опубликована: Апрель 28, 2017

Язык: Английский

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Pore-forming activity and structural autoinhibition of the gasdermin family

Nature, Год журнала: 2016, Номер 535(7610), С. 111 - 116

Опубликована: Июнь 7, 2016

Язык: Английский

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Pyroptosis: mechanisms and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)

Опубликована: Март 29, 2021

Abstract Currently, pyroptosis has received more and attention because of its association with innate immunity disease. The research scope expanded the discovery gasdermin family. A great deal evidence shows that can affect development tumors. relationship between tumors is diverse in different tissues genetic backgrounds. In this review, we provide basic knowledge pyroptosis, explain tumors, focus on significance tumor treatment. addition, further summarize possibility as a potential treatment strategy describe side effects radiotherapy chemotherapy caused by pyroptosis. brief, double-edged sword for rational use dual effect will help us explore formation ideas patients to develop new drugs based

Язык: Английский

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Mechanisms and disease consequences of nonalcoholic fatty liver disease

Cell, Год журнала: 2021, Номер 184(10), С. 2537 - 2564

Опубликована: Май 1, 2021

Язык: Английский

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Gasdermins: Effectors of Pyroptosis

Trends in Cell Biology, Год журнала: 2017, Номер 27(9), С. 673 - 684

Опубликована: Июнь 13, 2017

Язык: Английский

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Programmed cell death as a defence against infection

Nature reviews. Immunology, Год журнала: 2017, Номер 17(3), С. 151 - 164

Опубликована: Янв. 31, 2017

Язык: Английский

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Plasma membrane changes during programmed cell deaths

Cell Research, Год журнала: 2017, Номер 28(1), С. 9 - 21

Опубликована: Окт. 27, 2017

Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic apoptotic cell death, respectively. As such, apoptosis is usually a non-inflammatory process while necrosis triggers inflammation. Recent studies on necroptosis pyroptosis, two types programmed necrosis, revealed that membrane rupture mediated by MLKL channels during but depends non-selective gasdermin D (GSDMD) pores pyroptosis. Importantly, the morphology dying cells executed can be distinguished from GSDMD pores. Interestingly, it was found recently secondary cells, previously believed non-regulated form lysis occurs after apoptosis, pore formation like In addition, pyroptosis associated with pyroptotic bodies, which have some similarities to bodies. Therefore, different death programs induce distinctive reshuffling processes membrane. Given fact nature released intracellular contents plays crucial role in dying/dead cell-induced immunogenicity, not only or integrity also breakdown would determine fate well its ability elicit an immune response. this review, we will discuss recent advances field emphasis mechanisms underlying changes observed their implication death-elicited immunogenicity.

Язык: Английский

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