Cell Death and Differentiation,
Journal Year:
2018,
Volume and Issue:
25(3), P. 486 - 541
Published: Jan. 23, 2018
Over
the
past
decade,
Nomenclature
Committee
on
Cell
Death
(NCCD)
has
formulated
guidelines
for
definition
and
interpretation
of
cell
death
from
morphological,
biochemical,
functional
perspectives.
Since
field
continues
to
expand
novel
mechanisms
that
orchestrate
multiple
pathways
are
unveiled,
we
propose
an
updated
classification
subroutines
focusing
mechanistic
essential
(as
opposed
correlative
dispensable)
aspects
process.
As
provide
molecularly
oriented
definitions
terms
including
intrinsic
apoptosis,
extrinsic
mitochondrial
permeability
transition
(MPT)-driven
necrosis,
necroptosis,
ferroptosis,
pyroptosis,
parthanatos,
entotic
death,
NETotic
lysosome-dependent
autophagy-dependent
immunogenic
cellular
senescence,
mitotic
catastrophe,
discuss
utility
neologisms
refer
highly
specialized
instances
these
processes.
The
mission
NCCD
is
a
widely
accepted
nomenclature
in
support
continued
development
field.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: March 29, 2021
Abstract
Currently,
pyroptosis
has
received
more
and
attention
because
of
its
association
with
innate
immunity
disease.
The
research
scope
expanded
the
discovery
gasdermin
family.
A
great
deal
evidence
shows
that
can
affect
development
tumors.
relationship
between
tumors
is
diverse
in
different
tissues
genetic
backgrounds.
In
this
review,
we
provide
basic
knowledge
pyroptosis,
explain
tumors,
focus
on
significance
tumor
treatment.
addition,
further
summarize
possibility
as
a
potential
treatment
strategy
describe
side
effects
radiotherapy
chemotherapy
caused
by
pyroptosis.
brief,
double-edged
sword
for
rational
use
dual
effect
will
help
us
explore
formation
ideas
patients
to
develop
new
drugs
based
Cell Research,
Journal Year:
2017,
Volume and Issue:
28(1), P. 9 - 21
Published: Oct. 27, 2017
Ruptured
and
intact
plasma
membranes
are
classically
considered
as
hallmarks
of
necrotic
apoptotic
cell
death,
respectively.
As
such,
apoptosis
is
usually
a
non-inflammatory
process
while
necrosis
triggers
inflammation.
Recent
studies
on
necroptosis
pyroptosis,
two
types
programmed
necrosis,
revealed
that
membrane
rupture
mediated
by
MLKL
channels
during
but
depends
non-selective
gasdermin
D
(GSDMD)
pores
pyroptosis.
Importantly,
the
morphology
dying
cells
executed
can
be
distinguished
from
GSDMD
pores.
Interestingly,
it
was
found
recently
secondary
cells,
previously
believed
non-regulated
form
lysis
occurs
after
apoptosis,
pore
formation
like
In
addition,
pyroptosis
associated
with
pyroptotic
bodies,
which
have
some
similarities
to
bodies.
Therefore,
different
death
programs
induce
distinctive
reshuffling
processes
membrane.
Given
fact
nature
released
intracellular
contents
plays
crucial
role
in
dying/dead
cell-induced
immunogenicity,
not
only
or
integrity
also
breakdown
would
determine
fate
well
its
ability
elicit
an
immune
response.
this
review,
we
will
discuss
recent
advances
field
emphasis
mechanisms
underlying
changes
observed
their
implication
death-elicited
immunogenicity.
