Innate immune evasion strategies of SARS-CoV-2

Nature Reviews Microbiology, Год журнала: 2023, Номер unknown

Опубликована: Янв. 11, 2023

Язык: Английский

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Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses

Cell Host & Microbe, Год журнала: 2023, Номер 31(1), С. 146 - 157

Опубликована: Янв. 1, 2023

Язык: Английский

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T Cell Responses to SARS-CoV-2

Annual Review of Immunology, Год журнала: 2023, Номер 41(1), С. 343 - 373

Опубликована: Фев. 8, 2023

A large body of evidence generated in the last two and a half years addresses roles T cells SARS-CoV-2 infection following vaccination. Infection or vaccination induces multi-epitope CD4 CD8 cell responses with polyfunctionality. Early have been associated mild COVID-19 outcomes. In concert animal model data, these results suggest that while antibody are key to prevent infection, may also play valuable reducing disease severity controlling infection. memory after is sustained for at least six months. While neutralizing impacted by variants, most preserved. This review highlights extensive progress made, data knowledge gaps remain, our understanding vaccines.

Язык: Английский

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SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

Nature, Год журнала: 2023, Номер 617(7961), С. 592 - 598

Опубликована: Апрель 3, 2023

Язык: Английский

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Memory B cells

Nature reviews. Immunology, Год журнала: 2023, Номер 24(1), С. 5 - 17

Опубликована: Июль 3, 2023

Язык: Английский

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Estimates of SARS-CoV-2 Seroprevalence and Incidence of Primary SARS-CoV-2 Infections Among Blood Donors, by COVID-19 Vaccination Status — United States, April 2021–September 2022

MMWR Morbidity and Mortality Weekly Report, Год журнала: 2023, Номер 72(22), С. 601 - 605

Опубликована: Июнь 1, 2023

Changes in testing behaviors and reporting requirements have hampered the ability to estimate U.S. SARS-CoV-2 incidence (1). Hybrid immunity (immunity derived from both previous infection vaccination) has been reported provide better protection than that or vaccination alone (2). To of prevalence infection- vaccination-induced antibodies (or both), data a nationwide, longitudinal cohort blood donors were analyzed. During second quarter 2021 (April-June), an estimated 68.4% persons aged ≥16 years had antibodies, including 47.5% alone, 12.0% 8.9% both. By third 2022 (July-September), 96.4% vaccination, 22.6% 26.1% alone; 47.7% hybrid immunity. Prevalence was lowest among ≥65 (36.9%), group with highest risk for severe disease if infected, those 16-29 (59.6%). Low infection-induced older adults reflects success public health prevention efforts while also highlighting importance staying up date recommended COVID-19 at least 1 bivalent dose.*,†.

Язык: Английский

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SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

Immunity, Год журнала: 2022, Номер 55(10), С. 1764 - 1778

Опубликована: Авг. 18, 2022

Язык: Английский

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PANoptosis: Mechanisms, biology, and role in disease

Immunological Reviews, Год журнала: 2023, Номер 321(1), С. 246 - 262

Опубликована: Окт. 12, 2023

Summary Cell death can be executed through distinct subroutines. PANoptosis is a unique inflammatory cell modality involving the interactions between pyroptosis, apoptosis, and necroptosis, which mediated by multifaceted PANoptosome complexes assembled via integrating components from other modalities. There growing interest in process function of PANoptosis. Accumulating evidence suggests that occurs under diverse stimuli, for example, viral or bacterial infection, cytokine storm, cancer. Given impact across disease spectrum, this review briefly describes relationships highlights key molecules formation activation, outlines roles diseases together with potential therapeutic targeting. We also discuss important concepts pressing issues future research. Improved understanding its mechanisms crucial identifying novel targets strategies.

Язык: Английский

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Two centuries of vaccination: historical and conceptual approach and future perspectives

Frontiers in Public Health, Год журнала: 2024, Номер 11

Опубликована: Янв. 9, 2024

Over the past two centuries, vaccines have been critical for prevention of infectious diseases and are considered milestones in medical public health history. The World Health Organization estimates that vaccination currently prevents approximately 3.5-5 million deaths annually, attributed to such as diphtheria, tetanus, pertussis, influenza, measles. Vaccination has instrumental eradicating important pathogens, including smallpox virus wild poliovirus types 2 3. This narrative review offers a detailed journey through history advancements vaccinology, tailored healthcare workers. It traces pivotal milestones, beginning with variolation practices early 17th century, development first vaccine, continuous evolution innovation vaccine up present day. We also briefly immunological principles underlying vaccination, well main types, special mention recently introduced mRNA technology. Additionally, we discuss broad benefits vaccines, their role reducing morbidity mortality, fostering socioeconomic communities. Finally, address issue hesitancy effective strategies promote acceptance. Research, collaboration, widespread acceptance use imperative continued success programs controlling ultimately diseases.

Язык: Английский

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Immunological memory diversity in the human upper airway

Nature, Год журнала: 2024, Номер 632(8025), С. 630 - 636

Опубликована: Июль 31, 2024

Язык: Английский

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