Emerging treatment strategies in wound care

International Wound Journal, Год журнала: 2022, Номер 19(7), С. 1934 - 1954

Опубликована: Март 17, 2022

Abstract Wound healing is a complex process in tissue regeneration through which the body responds to dissipated cells as result of any kind severe injury. Diabetic and non‐healing wounds are considered an unmet clinical need. Currently, different strategic approaches widely used treatment acute chronic include, but not limited to, transplantation, cell therapy wound dressings, use instrument. A large number literatures have been published on this topic; however, most effective remains challenge. The dressing involves scaffold, usually using biomaterials for delivery medication, autologous stem cells, or growth factors from blood. Antibacterial anti‐inflammatory drugs also stop infection well accelerate healing. With increase ageing population leading diabetes associated cutaneous wounds, there great need improve current strategies. This research critically reviews advancement therapeutic regeneration. results recent trials suggest that modern dressings skin substitutes easiest, accessible, cost‐effective way treat with advances materials science such graphene 3D scaffold biomolecules hold significant promise. annual market value successful exceeds over $50 billion US dollars, will encourage industries academics investigate application emerging smart therapy.

Язык: Английский

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Electrospun fiber‐based immune engineering in regenerative medicine

Smart Medicine, Год журнала: 2024, Номер 3(1)

Опубликована: Фев. 1, 2024

Abstract Immune engineering, a burgeoning field within regenerative medicine, involves spectrum of strategies to optimize the intricate interplay between tissue biomaterials and host tissue. These are applied across different types various disease models, which encompasses finely modulating immune response at levels cells factors, aiming mitigate adverse effects like fibrosis persistent inflammation that may arise injury site consequently promote regeneration. With continuous progress in electrospinning technology, immunoregulatory capabilities electrospun fibers have gained substantial attention over years. Electrospun fibers, with their extracellular matrix‐like characteristics, high surface‐area‐to‐volume ratio, reliable pharmaceutical compound capacity, emerged as key players among engineering materials. This review specifically focuses on role fiber‐based emphasizing unique design strategies. Notably, actively engages by responses through four essential strategies: (i) surface modification, (ii) drug loading, (iii) physicochemical parameters, (iv) biological grafting. presents comprehensive overview mechanisms system injured tissues while unveiling adopted orchestrate regulation. Furthermore, explores current developmental trends limitations concerning function drive advancements its full potential.

Язык: Английский

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Emerging Bioprinting for Wound Healing

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Авг. 11, 2023

Bioprinting has attracted much attention due to its suitability for fabricating biomedical devices. In particular, bioprinting become one of the growing centers in field wound healing, with various types bioprinted devices being developed, including 3D scaffolds, microneedle patches, and flexible electronics. Bioprinted can be designed specific biostructures biofunctions that closely match shape sites accelerate regeneration skin through approaches. Herein, a comprehensive review smart dressings is presented, emphasizing crucial effect determining biofunctions. The begins an overview techniques devices, followed in-depth discussion polymer-based inks, modification strategies, additive ingredients, properties, applications. strategies are divided into seven categories, chemical synthesis novel physical blending, coaxial bioprinting, multimaterial absorption, immobilization, hybridization living cells, examples presented. Thereafter, frontiers 4D artificial intelligence-assisted situ discussed from perspective interdisciplinary sciences. Finally, current challenges future prospects this highlighted.

Язык: Английский

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Natural polymers in wound healing: From academic studies to commercial products

Journal of Applied Polymer Science, Год журнала: 2023, Номер 140(22)

Опубликована: Апрель 12, 2023

Abstract Natural biopolymers (carbohydrates and proteins) are the family of natural polymers that widely used in wound healing. This is due to their biocompatibility chemical structural similarity extracellular matrix (ECM). Wound healing a complex process requires multidisciplinary approach appropriate treatment product enable full recovery. Chronic nonhealing wounds significantly caused reduction. Currently, diabetic considered unmet clinical need new effective will benefit patients economy. research was aimed critically review both literature as well industrial products carbohydrates proteins dressing for wound. The outcome chitosan (CS), carbohydrate, has most application it readily available affordable, shown excellent antibacterial activity. Among proteins, keratin (Kr) can be an option with similar characteristics, however, Kr not yet found use when compared CS.

Язык: Английский

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Angiogenesis, hemocompatibility and bactericidal effect of bioactive natural polymer‐based bilayer adhesive skin substitute for infected burned wound healing

Bioactive Materials, Год журнала: 2023, Номер 29, С. 177 - 195

Опубликована: Июль 15, 2023

Thermal wounds are complex and lethal with irregular shapes, risk of infection, slow healing, large surface area. The mortality rate in patients infected burns is twice that non-infected burns. Developing multifunctional skin substitutes to augment the healing vital. Herein, we 3D printed a hydrogel scaffold comprising carboxymethyl chitosan (CMCs) oxidized alginate grafted catechol (O-AlgCat) on hydrophobic electrospun layer, forming bilayer substitute (BSS). functional layer (FL) was fabricated by physiochemical crosslinking ensure favorable biodegradability. gallium-containing or backing (BL) could mimic epidermis skin, avoiding fluid penetration offering antibacterial activity. FL contains catechol, gallium, biologically active platelet rich fibrin (PRF) adhere both tissue BL, show activity, encourage angiogenesis, cell growth, migration. bioactive BSS exhibited noticeable adhesive properties (P ≤ 0.05), significant activity faster clot formation, potential promote proliferation 0.05) migration L929 cells. Furthermore, angiogenesis significantly higher when evaluated vivo ovo. BSS-covered healed due low inflammation high collagen density. Based obtained results, be an effective treatment for burn wounds.

Язык: Английский

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Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

Drug Delivery, Год журнала: 2024, Номер 31(1)

Опубликована: Фев. 16, 2024

Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative traditional dressings such gauze. This is primarily attributed its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering moist environment supports effective healing. Additionally, hydrogel facilitates the penetration loaded therapeutic agents throughout surface, combating pathogens through hydration effect thereby enhancing healing process. However, presence eschar formation on obstructs passive diffusion therapeutics, impairing efficacy dressing, particularly in cases severe burns involving deeper tissue damage. review focuses exploring carrier for transdermal drug delivery treatment. Furthermore, strategies aimed at from optimize also discussed.

Язык: Английский

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Bio‐Inspired Porous Microneedles Dwelled Stem Cells for Diabetic Wound Treatment

Advanced Functional Materials, Год журнала: 2024, Номер 34(28)

Опубликована: Фев. 6, 2024

Abstract Diabetic wound healing is a serious, complex, and chronic process; one current promising focusing technology in this area stem cell treatment. Here, novel porous microneedle (MN) arrays fabricated, which can highly mimetic niches, through template filling, particle etching method. The human adipose‐derived cells (ADSCs) are encapsulated Matrigel then loaded into the MN by post‐perfusion. Because of extracellular matrix‐mimicking, biocompatible offers bionic microenvironment nest suitable for growth. Benefiting from numerous pore structures MNs, ADSCs have enough space to fully absorb nutrients, proliferate greatly exhibit prompted function. In addition, cell‐loaded mechanical strength penetrate skin, allowing get deep areas. Based on these features, performance resultant promoting tissue regeneration demonstrated, collagen deposition angiogenesis diabetes wounds rat models. Thus, it believe that bioinspired MNs act as excellent scaffolds will find many practical values clinic healing.

Язык: Английский

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An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Macromolecular Bioscience, Год журнала: 2022, Номер 22(7)

Опубликована: Апрель 14, 2022

A wound can be surgical cuts from an operation or due to accident and trauma. The infected wound, as a result of bacteria growth within the damaged skin, interrupts natural healing process significantly impacts quality life. Wound dressing is important segment skincare industry with its economic burden estimated at $ 20.4 billion (in 2021) in global market. results recent clinical trials suggest that use modern dressings easiest, most accessible, cost-effective way treat chronic wounds and, hence, holds significant promise. With sheer number market, selection correct confusing for clinicians healthcare workers. aim this research review widely used types antibacterial dressings, well emerging products, their efficiency mode action. In review, introducing antibiotics nanoparticles two clinically categories agents focused. perspectives challenges paving future field are also discussed.

Язык: Английский

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Preparation of a biomimetic bi-layer chitosan wound dressing composed of A-PRF/sponge layer and L-arginine/nanofiber

Carbohydrate Polymers, Год журнала: 2022, Номер 292, С. 119648 - 119648

Опубликована: Май 23, 2022

Язык: Английский

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Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8778 - 8778

Опубликована: Авг. 7, 2022

Wound dressing design is a dynamic and rapidly growing field of the medical wound-care market worldwide. Advances in technology have resulted development wide range wound dressings that treat different types wounds by targeting four phases healing. The ideal should perform rapid healing; preserve body's water content; be oxygen permeable, non-adherent on hypoallergenic; provide barrier against external contaminants-at reasonable cost with minimal inconvenience to patient. Therefore, choosing best based what needs does achieve complete regeneration restoration skin's structure function. Biopolymers, such as alginate (ALG), chitosan (Cs), collagen (Col), hyaluronic acid (HA) silk fibroin (SF), are extensively used management due their biocompatibility, biodegradability similarity macromolecules recognized human body. However, most formulations biopolymers still show various issues; thus, strategies combine them molecular biology approaches represent future this article provides an overview biopolymers' roles physiology perspective new generation enhanced, naturally inspired, smart blood products, stem cells growth factors.

Язык: Английский

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