Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention DOI Creative Commons
Shan Jiang, Ziyi Cao, Siming Yu

и другие.

International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 5593 - 5609

Опубликована: Ноя. 1, 2024

Diabetic kidney disease (DKD) is a form of damage resulting from diabetes and represents common, severe complication the disease. Globally, DKD leading cause chronic (CKD). occurs in both type 1 2 patients, with early clinical manifestations including microalbuminuria hypertension. As condition progresses, symptoms such as massive proteinuria, hypoalbuminemia, edema may appear. The key to treating lies controlling blood glucose pressure, reducing slowing deterioration function. Acupuncture, traditional Chinese medicine treatment, has shown some therapeutic effects on through mechanisms regulating glucose, improving renal flow microcirculation, antioxidation anti-inflammation, modulating gut microbiota.

Язык: Английский

FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism DOI Creative Commons
Kaili Chang, Fu‐Yuan Hong, Hong Liu

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер 235, С. 116819 - 116819

Опубликована: Фев. 21, 2025

Язык: Английский

Процитировано

1

Higher Circulating Neutrophil Counts Is Associated with Increased Risk of All-Cause Mortality and Cardiovascular Disease in Patients with Diabetic Kidney Disease DOI Creative Commons

Ruiyan Xie,

David Bishai, David Tak Wai Lui

и другие.

Biomedicines, Год журнала: 2024, Номер 12(8), С. 1907 - 1907

Опубликована: Авг. 20, 2024

Accumulating evidence has suggested the pathogenic roles of chronic inflammation and neutrophils in diabetic kidney disease (DKD). This study investigated relationship between neutrophils, all-cause, cardiovascular (CVD) mortality type 2 diabetes mellitus (T2DM) patients with DKD.

Язык: Английский

Процитировано

4

Label-free multimodal optical biopsy reveals biomolecular and morphological features of diabetic kidney tissue in 2D and 3D DOI Creative Commons
Anthony A. Fung, Zhi Li, Craig Boote

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Май 15, 2025

Abstract Kidney disease, the ninth leading cause of death in United States, suffers from poor diagnostic efficiency (10%). Traditional biopsies use molecular reagents to enhance power but are limited by overlapping spatial and chromatic signals, product quality variability, additional processing. To address these challenges without disrupting routine diagnostics, we implement label-free imaging modalities—stimulated Raman scattering (SRS), second harmonic generation (SHG), two-photon fluorescence (TPF)—within a single setup. We identify morphological, lipidomic, metabolic biomarkers control diabetic kidney samples at subcellular resolution. Label-free Stimulated Histology (SRH) reveals distinct collagen morphology, mesangial-glomerular volumes, lipid saturation, redox status, lipid-protein concentrations previously unrecognized diseases. Using same tissue section enhances value compromising tissue. These multimodal broadly deepen understanding disease progression integrating fibrotic, data.

Язык: Английский

Процитировано

0

Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy DOI Creative Commons

Fengxia Zhang,

Xianhu Tang,

Zhimei Zeng

и другие.

Open Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Abstract Introduction Diabetic kidney disease (DKD) represents serious diabetes-associated complications, and podocyte loss is an important histologic sign of DKD. The cellular molecular profiles podocytes in DKD have yet to be fully elucidated. Methods This study analyzed kidney-related single-nucleus RNA-seq datasets (GSE131882, GSE121862, GSE141115) human diabetic glomeruli transcriptome profiling (GSE30122). ARHGAP28 expression was validated by western blot immunohistochemistry. Results In tissues, 154 differentially expressed genes (DEGs) were identified podocytes, which enriched biological processes related nephron development extracellular matrix–receptor interactions. Similarly, the mouse kidney, 344 DEGs found, clustering pathways associated with renal signaling mechanisms like PI3K/Akt (phosphatidylinositol-3 kinase/protein kinase B) PPAR (peroxisome proliferator-activated receptor). glomeruli, 438 identified, showing significant enrichment nephropathy. Venn analysis revealed 22 common across being notably overexpressed podocytes. nephropathy model using db/db mice showed that significantly upregulated cortex glomeruli. vitro studies a high-glucose corroborated these findings. Conclusions Collectively, this provides insight into function diagnosis indicates potential biomarker

Язык: Английский

Процитировано

0

Targeting lipid metabolic reprogramming to alleviate diabetic kidney disease: molecular insights and therapeutic strategies DOI Creative Commons
Wei Yu, Haoyu Yang, Zhou Ling

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 25, 2025

Diabetic kidney disease (DKD) is one of the major complications diabetes, and its pathological progression closely associated with lipid metabolic reprogramming. Under diabetic conditions, renal cells undergo significant abnormalities, including increased uptake, impaired fatty acid oxidation, disrupted cholesterol efflux, enhanced catabolism, as adaptive responses to stress. These changes result in accumulation lipids such free acids, diacylglycerol, ceramides, leading lipotoxicity that triggers inflammation fibrosis. Hypoxia DKD microenvironment suppresses oxidation promotes synthesis through HIF-1α pathway, while chronic exacerbates disturbances via inflammatory cytokines, inflammasomes, macrophage polarization. Targeting metabolism represents a promising therapeutic strategy for alleviating DKD; however, further clinical translational studies are warranted validate efficacy safety these approaches.

Язык: Английский

Процитировано

0

Mechanism and Therapeutic Targets of Circulating Immune Cells in Diabetic Retinopathy DOI Creative Commons
Bowen Zhao, Yin Zhao, Xufang Sun

и другие.

Pharmacological Research, Год журнала: 2024, Номер 210, С. 107505 - 107505

Опубликована: Ноя. 14, 2024

Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within retinal microenvironment. Typically, retina is considered as an immune-privileged organ, where circulating cells are restricted from entry under normal conditions. However, during progression DR, this privilege compromised breach barrier and infiltrate retina. Increasing evidence suggests that vascular neuronal degeneration in DR largely driven infiltration cells, particularly neutrophils, monocyte-derived macrophages, lymphocytes. This review delves into mechanisms therapeutic targets associated with these cell populations offering a promising innovative approach managing disease.

Язык: Английский

Процитировано

2

Association Between Weight-Adjusted Waist Index and Albuminuria in Type 2 Diabetes Mellitus in the Chinese Population DOI Creative Commons
Qin Yu, Jingjing Ye, Haoxiang Li

и другие.

Diabetes Metabolic Syndrome and Obesity, Год журнала: 2024, Номер Volume 17, С. 3585 - 3592

Опубликована: Сен. 1, 2024

This study aimed to investigate the relationship between weight-adjusted waist index (WWI) and albuminuria in patients with type 2 diabetes mellitus (T2DM) Chinese population.

Язык: Английский

Процитировано

0

Label-Free Optical Biopsy Reveals Biomolecular and Morphological Features of Diabetic Kidney Tissue in 2D and 3D DOI Creative Commons
Anthony A. Fung, Zhi Li, Craig Boote

и другие.

Опубликована: Окт. 29, 2024

Abstract Kidney disease, the ninth leading cause of death in United States, has one poorest diagnostic efficiencies only 10% 1 . Conventional methods often rely on light microscopy analysis 2D fixed tissue sections with limited molecular insight compared to omics studies. Targeting multiple features a biopsy using or chemical reagents can enhance phenotyping but are by overlap their spatial and chromatic properties, variations quality products, multimodal nature need additional processing. To overcome these limitations increase breadth information available from without an impact routine workup, we implemented label-free imaging modalities including stimulated Raman scattering (SRS) microscopy, second harmonic generation (SHG), two photon fluorescence (TPF) into single setup. We visualized identified morphological, structural, lipidomic, metabolic biomarkers control diabetic human kidney samples 3D at subcellular resolution. The biomarkers, collagen fiber morphology, mesangial-glomerular fractional volume, lipid saturation, redox status, relative protein concentrations form Stimulated Histology (SRH), illustrate distinct disease tissues not previously appreciated. same section be used for work up thus enhancing power cliniopathological insights obtainable compromising already tissue. metrics broadly applicable deepen our understanding progression diseases integrating fibrotic, data. Figure Graphical Label-free indicators nephropathies.

Язык: Английский

Процитировано

0

Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention DOI Creative Commons
Shan Jiang, Ziyi Cao, Siming Yu

и другие.

International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 5593 - 5609

Опубликована: Ноя. 1, 2024

Diabetic kidney disease (DKD) is a form of damage resulting from diabetes and represents common, severe complication the disease. Globally, DKD leading cause chronic (CKD). occurs in both type 1 2 patients, with early clinical manifestations including microalbuminuria hypertension. As condition progresses, symptoms such as massive proteinuria, hypoalbuminemia, edema may appear. The key to treating lies controlling blood glucose pressure, reducing slowing deterioration function. Acupuncture, traditional Chinese medicine treatment, has shown some therapeutic effects on through mechanisms regulating glucose, improving renal flow microcirculation, antioxidation anti-inflammation, modulating gut microbiota.

Язык: Английский

Процитировано

0