Molecular biomarker research in periodontology: A roadmap for translation of science to clinical assay validation

Journal Of Clinical Periodontology, Год журнала: 2022, Номер 49(6), С. 556 - 561

Опубликована: Март 24, 2022

The number of studies that aims to apply host- or microbe-derived biochemical biomarkers periodontal disease diagnosis has increased significantly during the last three decades. markers can reflect presence, severity, and activity diseases; however, heterogeneities in applied laboratory methods, data presentation, statistical analysis, interpretation prevent translation candidate clinical assay validation. Here, we propose a roadmap for making research outcomes comparable re-analysable with ultimate goal translating practice. This presents reporting recommendations biomarker periodontology. We aim make essential elements work (including diagnostic criteria, endpoint definitions, participant recruitment sample collection storage techniques, microbiological detection analysis) visible comparable.

Язык: Английский

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Polymeric nanotechnologies for the treatment of periodontitis: A chronological review

International Journal of Pharmaceutics, Год журнала: 2022, Номер 625, С. 122065 - 122065

Опубликована: Авг. 3, 2022

Periodontitis is a chronic infectious and inflammatory disease of periodontal tissues estimated to affect 70-80 % all adults. At the same time, periodontium, site pathologies, an extraordinarily complex plexus soft hard tissues, regeneration which using even most advanced forms tissue engineering continues be challenge. Nanotechnologies, meanwhile, have provided exquisite tools for producing biomaterials pharmaceutical formulations capable elevating efficacies standard pharmacotherapies surgical approaches whole new levels. A bibliographic analysis here demonstrates continuously increasing research output studies on use nanotechnologies in management disease, when they are normalized total periodontitis. The great majority used tackle periodontitis, including those that pioneered this interesting field, been polymeric. In article, chronological review polymeric treatment periodontitis provided, focusing major conceptual innovations since late 1990s, first nanostructures diseases were fabricated. opening sections, etiology pathogenesis anatomical histological characteristics periodontium being described, along with general clinical manifestations means its therapy. prospective chemistries design polymers these applications also elaborated. It concluded amount innovation field rise, despite fact focused refinement already established paradigms rather than development revolutionary concepts.

Язык: Английский

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Subgingival instrumentation

Periodontology 2000, Год журнала: 2023, Номер unknown

Опубликована: Май 10, 2023

The S3-level clinical guidelines for the treatment of patients with periodontitis stages I-III published by European Federation Periodontology in 2020, suggest a pre-established stepwise approach oral-healthcare professionals precise therapeutic pathways. second step this consists subgingival instrumentation periodontal pockets non-surgical means to disrupt microbial biofilm and remove soft mineralized deposits This aims resolve inflammation closure (probing pocket depth ≤ 4 mm, absence bleeding on probing) employing different types instruments protocols toward end. Novel approaches that adopt micro or application biological agents have been recently tested. Subgingival has shown effectively restore microbiota one associated health modulate inflammatory response. outcomes be evaluated order guide therapist providing additional but focused remaining OR at sites residual inflammation. Of great importance is impact patient's well-being, based evidence emerges from studies evaluating patient related quality life.

Язык: Английский

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The efficacy of combining adjuvants with non‐surgical periodontal therapy in individuals with type 2 diabetes: A Bayesian network meta‐analysis

Journal Of Clinical Periodontology, Год журнала: 2024, Номер 51(5), С. 610 - 630

Опубликована: Фев. 11, 2024

Abstract Aim This Bayesian network meta‐analysis of randomized controlled trials assessed the effect adjuvant periodontal treatment in both and HbA1c outcomes adult individuals with type 2 diabetes (T2DM). Materials Methods A systematic search was done up to February 2023 comparing sub‐gingival debridement (SD) combination local or systemic SD alone for T2DM. The primary were changes absolute levels full‐mouth probing depth reported at 3‐ 6‐month post‐treatment. Results Seventy‐two eligible publications evaluating 27 treatments retrieved. antibiotic metronidazole antioxidant alpha lipoic acid provided, respectively, 1.4% (95% credible interval [CrI] 0.48; 2.20) 2.4% CrI 1.50; 3.30) more significant improvement on levels, 0.89 mm 0.23; 1.50) 0.92 0.02; 0.92) greater reductions. Other provided added benefit without discernible effects HbA1c. Conclusions Adjuvant use best adjunct option provide clinically meaningful However, no strong recommendation can be drawn due scarcity studies each low certainty resultant evidence.

Язык: Английский

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Objective masticatory efficiency and subjective quality of masticatory function among patients with periodontal disease

Journal Of Clinical Periodontology, Год журнала: 2020, Номер 47(11), С. 1344 - 1353

Опубликована: Сен. 6, 2020

To examine patient-centred clinical outcomes for objective masticatory efficiency (OME) and subjective quality of function (QMF) among periodontitis patients using test methods easily applicable in daily practice.Cross-sectional investigation undergoing supportive periodontal therapy (n = 224). Outcomes included OME QMF related to characteristics.OME were associated (x2 0.252, p 0.037) showed highest values stage 4 according the new classification disease. There correlations particularly 2 between number teeth -0.317, < 0.001), Quigley-Hein Index 0.152, 0.031), attachment level 0.268, probing depths 0.185, 0.006), tooth mobility 0.147, 0.031) functional occlusal units -0.423, 0.001) but not bleeding on probing. A trend existed -0.237, 0.050) 0.238, 0.058), other findings.OME represent each are 4. Periodontitis findings influence 2, gingival inflammation does not. Number with QMF, while have less impact. An assessment mastication should be routinely diagnosis all stages.

Язык: Английский

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