The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

Journal of Pharmaceutical Analysis, Год журнала: 2023, Номер 14(2), С. 157 - 176

Опубликована: Сен. 27, 2023

Heart failure (HF) is a highly morbid syndrome that seriously affects the physical and mental health of patients generates an enormous socio-economic burden. In addition to cardiac myocyte oxidative stress apoptosis, which are considered mechanisms for development HF, alterations in energy metabolism pathological autophagy also contribute abnormalities ultimately HF. Silent information regulator 1 (Sirt1) adenosine monophosphate-activated protein kinase (AMPK) nicotinamide adenine dinucleotide (NAD

Язык: Английский

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Downregulation of miR-410-3p via the METRNL-mediated AMPK/SIRT1/NF-κB signaling axis inhibits oxidative stress and inflammation in idiopathic pulmonary fibrosis

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111667 - 111667

Опубликована: Фев. 1, 2025

Язык: Английский

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Exploring the inflammation-related mechanisms of Lingguizhugan decoction on right ventricular remodeling secondary to pulmonary arterial hypertension based on integrated strategy using UPLC-HRMS, systems biology approach, and experimental validation

Phytomedicine, Год журнала: 2024, Номер 132, С. 155879 - 155879

Опубликована: Июль 14, 2024

Язык: Английский

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Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway

Drug Design Development and Therapy, Год журнала: 2022, Номер Volume 16, С. 4111 - 4125

Опубликована: Дек. 1, 2022

Purpose: Despite significant advances in interventional treatment, myocardial infarction (MI) and subsequent cardiac fibrosis remain major causes of high mortality worldwide. Liquiritin (LQ) is a flavonoid extract from licorice that possesses variety pharmacological properties. However, to our knowledge, the effects LQ on after MI have not been reported detail. The aim research was explore potential role mechanism MI-induced damage. Methods: models were established by ligating left anterior descending branch coronary artery. Next, rats orally administered once day for 14 days. Biochemical assays, histopathological observations, ELISA, Western blotting analyses then conducted. Results: improved heart appearance ECG, decreased weight index reduced levels cardiac-specific markers such as CK, CK-MB, LDH, cTnI BNP. Meanwhile, infarct size hemodynamic parameters LVEDP, LVSP ±dp/dt max . Moreover, H&E staining showed attenuated pathological damage caused MI. Masson alleviated cell disorder while reducing collagen deposition. also oxidative stress inflammation. demonstrated significantly down-regulated expressions Collagen I, III, TGF-β 1, MMP-9, α-SMA, CCL5, p-NF-κB. Conclusion: protected against following improving function, attenuating inflammatory response, which may be associated with inhibition CCL5 expression NF-κB pathway. Keywords: liquiritin, fibrosis, infarction, expression, signaling pathway A Letter Editor has published this article

Язык: Английский

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Spectrum–effect relationship between HPLC fingerprints and antioxidant activity of Qi‐Fu‐Yin based on multiple statistical correlation analysis

Phytochemical Analysis, Год журнала: 2024, Номер 35(7), С. 1565 - 1576

Опубликована: Май 22, 2024

Abstract Introduction Qi‐Fu‐Yin has been used to treat Alzheimer's disease (AD) in China. Oxidative stress recognized as a factor AD progress. To date, there is no quality control method ensure batch‐to‐batch consistency of Qi‐Fu‐Yin, and the potential antioxidant compounds remain uncertain. Objectives The aim this study identify establish standards for Qi‐Fu‐Yin. Methods High‐performance liquid chromatography was quantify fingerprints from various batches. Ultrahigh‐performance coupled with quadrupole time‐of‐flight tandem mass spectrometry (UHPLC‐Q‐TOF/MS) common peaks. Bivariate correlation analysis, partial least squares regression gray analysis were spectrum–effect relationship. Results Forty‐nine peaks determined through establishment fingerprints. Among them, 35 preliminarily characterized. multiple statistical methods identified six constituents their activities validated vitro. All derived two herbs. Therefore, three chemical index other herbs added quantitative while herbs, could be included. Eventually, quantitatively provide relatively comprehensive Conclusions elucidated substance basis provided approach assay which promising advance

Язык: Английский

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Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis

Life Sciences, Год журнала: 2024, Номер 343, С. 122536 - 122536

Опубликована: Фев. 28, 2024

Язык: Английский

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Effects of Crude Extract of Glycyrrhiza Radix and Atractylodes macrocephala on Immune and Antioxidant Capacity of SPF White Leghorn Chickens in an Oxidative Stress Model

Antioxidants, Год журнала: 2024, Номер 13(5), С. 578 - 578

Опубликована: Май 8, 2024

The natural edible characteristics of Chinese herbs have led more and people to study them as an alternative product antibiotics. In this study, crude extracts Glycyrrhiza radix Atractylodes macrocephala (abbreviated GRAM) with glycyrrhizic acid content not less than 0.2 mg/g were selected evaluate the effects GRAM on immune antioxidant capacity model animals. Thirty 21-day-old male Leghorn chickens weighed randomly assigned one three groups ten animals each. treatments comprised a control group (CON), in which saline was injected at day 31, 33, 35, LPS-treated (LPS), LPS (0.5 mg/kg BW) finally group, (G-L) GRAM-treated diet (at 2 g/kg) fed from 21 35 injection 35. results diarrhea grade serum measurement showed that had obvious symptoms, ROS MDA significantly increased, T-AOC decreased. oxidative stress successfully established. indexes feeding decreased levels pro-inflammatory factors TNF-α, IL-1β, IL-6 (p < 0.05) increased anti-inflammatory IL-4 IL-10 enzymes GSH-Px CAT 0.05). resisted influence ileum morphology, liver, organs maintained normal index values for organs. summary, confirmed antidiarrheal effect GRAM, improved by regulating inflammatory cytokine enzyme activity poultry.

Язык: Английский

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Analyzing How Zhizi Baipi Decoction Regulates VEGF to Suppress RA Angiogenesis Using Network Pharmacology and Experimental Validation

Phytochemical Analysis, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily manifests with symptoms such as heat and toxin. However, the key components molecular mechanisms of Zhizi Baipi decoction (ZBD) in treatment RA are still unclear. The study aimed to explore mechanism action ZBD for treating through ingredient analysis, network pharmacology, experimental validation. chemical constituents were identified by ultra-high performance liquid chromatography coupled Q-TOF-mass spectrometry (UPLC-Q-TOF-MSE). Additionally, active ingredients screened pharmacology using docking verify binding energy ZBD's targets. Then we elucidated on collagen-induced (CIA) model rats. Subsequently, validations used validate findings pharmacology. A total 84 was UPLC-Q-TOF-MSE. results indicated could exert its therapeutic effect vascular endothelial growth factor (VEGF) pathway. Molecular revealed strong capacity between target KDR ingredients. quantified five ZBD. In vivo experiments demonstrated inhibited synovial angiogenesis alleviated occurrence progression RA. Overall, has significant qualitative docking, main modulate VEGF pathway treat

Язык: Английский

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Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 14, 2025

Background Clinical evidence suggests that pulmonary fibrosis (PF) and heart failure (HF) often co-exist; however, the specific impact of PF on HF remains underexplored. This gap in understanding complicates management treatment patients with PF. Objectives To investigate effects cardiac function myocardial using a mouse model evaluate therapeutic potential wogonin, flavonoid compound known for its anti-PF properties. Methods A was established via intratracheal administration bleomycin (BLM). Starting day 8 post-BLM treatment, wogonin (50 mg/kg) intraperitoneally administered every 2 days weeks. Cardiac assessed echocardiography, while evaluated through Masson staining. In vitro , H9C2 cardiomyocytes were exposed to CoCl or H O 24 h without (20 μM) treatment. Apoptosis DNA damage markers analysed immunofluorescence, immunoblotting, Comet assay. The interaction between Sirt1 examined biotin-affinity pulldown assays molecular docking simulations. Results Mice exhibited significant dysfunction fibrosis. Wogonin markedly improved ejection fraction attenuated mice. Mechanistic studies revealed alleviated cardiomyocyte apoptosis by upregulating downregulating γ-H2AX expression. Docking simulations predicted forms stable complex hydrogen-bonding hydrophobic interactions, which further validated assays. Conclusion exerts protective against mice modulating Sirt1/γ-H2AX-mediated pathways reduce apoptosis. These findings suggest as agent managing associated

Язык: Английский

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Integrating Spatial Mapping and Metabolomics: A Novel Platform for Bioactive Compound Discovery and Saline Land Reclamation

Computational and Structural Biotechnology Journal, Год журнала: 2025, Номер 27, С. 1741 - 1753

Опубликована: Янв. 1, 2025

Язык: Английский

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