Redox changes in obesity, metabolic syndrome, and diabetes

Redox Biology, Год журнала: 2021, Номер 42, С. 101887 - 101887

Опубликована: Фев. 6, 2021

"Life is an instantaneous encounter of circulating matter and flowing energy" (Jean Giaja, Serbian physiologist), one the most elegant definitions not only life but relationship redox biology metabolism. Their evolutionary liaison has created inseparable yet dynamic homeostasis in health, which, when disrupted, leads to disease. This interconnection even more pertinent today, era increasing metabolic diseases epidemic proportions such as obesity, syndrome, diabetes. Despite great advances understanding molecular mechanisms regulation, we face significant challenges preventing, diagnosing, treating diseases. The etiological association temporal overlap these syndromes present for discrimination appropriate clinical biomarkers diagnosis, treatment, outcome prediction. These multifactorial, multiorgan with complex etiopathogenic are accompanied by disturbed equilibrium target tissues circulation. Free radicals reactive species considered both a causal factor consequence disease status. Thus, determining subtypes levels free species, oxidatively damaged biomolecules (lipids, proteins, nucleic acids) antioxidant defense components well redox-sensitive transcription factors fluxes redox-dependent pathways will help define existing establish novel stratifying review aims discuss diverse redox/metabolic aspects diabetes, imperative platform emerging future redox-metabolic research precision medicine. Future warrants detailed investigations into status healthy subjects patients, including use 'omic' profiling technologies (e.g., proteomes, lipidomes, metabolomes, transcriptomes), taking account influence lifestyle (diet, physical activity, sleep, work patterns) circadian ~24h fluctuations circulatory metabolites.

Язык: Английский

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Chrono-Nutrition: Circadian Rhythm and Personalized Nutrition

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2571 - 2571

Опубликована: Янв. 29, 2023

The human circadian system has a period of approximately 24 h and studies on the consequences “chornodisruption” have greatly expanded. Lifestyle environmental factors modern societies (i.e., artificial lighting, jetlag, shift work, around-the-clock access to energy-dense food) can induce disruptions thereby adversely affect individual health. Growing evidence demonstrates complex reciprocal relationship between metabolism system, in which perturbations one other one. From nutritional genomics perspective, genetic variants clock genes both influence metabolic health modify response diet. Moreover, an interplay rhythm, gut microbiome, epigenome been demonstrated, with diet turn able modulate this link suggesting remarkable plasticity underlying mechanisms. In view, study impact timing eating by matching elements from research chrono-biology, that is, chrono-nutrition, could significant implications for personalized nutrition terms reducing prevalence burden chronic diseases. This review provides overview current interactions nutrition, highlighting how microbiome. addition, possible strategies manage circadian-aligned feeding are suggested.

Язык: Английский

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Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies

Nutrients, Год журнала: 2025, Номер 17(3), С. 529 - 529

Опубликована: Янв. 31, 2025

Fasting-feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal underscores importance maintaining alignment order to avoid creating metabolic environment conducive carcinogenesis following molecular systemic disruption performance immune function. chronicity such condition may support initiation progression cancer through variety mechanisms, including increased oxidative stress, suppression, activation proliferative signaling pathways. This review aims summarize current evidence from human studies provide an overview potential mechanisms underscoring role chrononutrition (including time-restricted eating) on risk. Current shows that morning chronotype, suggesting physiological rhythms eating timing, associated with lower risk cancer. Also, early prolonged nighttime fasting were also suggests chronotype influences cell cycle regulation, modulation pathways inflammation, gut microbiota fluctuations. In conclusion, although there are no clear guidelines this matter, emerging supports hypothesis time-related (i.e., time/calorie-restricted feeding intermittent/periodic fasting) could potentially lead reduced

Язык: Английский

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Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity

Cell Metabolism, Год журнала: 2022, Номер 34(10), С. 1472 - 1485.e6

Опубликована: Сен. 9, 2022

Язык: Английский

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Seven decades of Ramadan intermittent fasting research: Bibliometrics analysis, global trends, and future directions

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2022, Номер 16(8), С. 102566 - 102566

Опубликована: Июль 8, 2022

Язык: Английский

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Breast Milk and the Importance of Chrononutrition

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Май 12, 2022

During pregnancy the human fetus receives timed cues from circadian rhythms of temperature, metabolites, and hormones mother. This influence is interrupted after parturition, infant does not secrete melatonin their are still immature. However, evolution provided solution to this problem. The newborn can continue receiving mother's through breastmilk. Colostrum, transitional, mature milk extraordinary complex biofluids that besides nutrients, contain an array other non-nutritive components. Upon birth first milk, colostrum, rich in bioactive, immunological factors, oligosaccharides which help proper establishment microbiome gut, crucial for infants' health. Hormones, such as glucocorticoids melatonin, transfer plasma then exposed Also, components fat, proteins, amino acids, endogenous cannabinoids, among others, have a markedly different concentration between day night. In present review, we give overview nutritive daily explore physiological importance infant. Finally, highlight some interventions with approach emphasize survival, growth, development. It estimated ~600,000 deaths/year due suboptimal breastfeeding. advisable increase rate exclusive breastfeeding, during night, was established by our species.

Язык: Английский

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Circadian rhythms, gut microbiota, and diet: Possible implications for health

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2023, Номер 33(8), С. 1490 - 1500

Опубликована: Май 15, 2023

Over the past years, interest in chrono-nutrition has grown enormously as fundamental role of circadian rhythms regulating most physiological and metabolic processes become clearer. Recently, influence on gut microbiota (GM) composition also emerged, more than half total microbial fluctuates rhythmically throughout day. At same time, other studies have observed that GM itself synchronises host's biological clock through signals a different nature. Therefore, it been hypothesised there is two-way communication between host GM, but researchers only just begun to identify some its action mechanisms. The manuscript aim is, therefore, gather combine latest evidence field with recent research order investigate their relationship potential impact human health.Considering current evidence, desynchronization closely associated an alteration abundance functionality consequent deleterious effects health, such increased risk numerous pathologies, including cardiovascular disease, cancer, irritable bowel depression. A key maintaining balance seems be attributed meal-timing diet quality, well certain metabolites, particular short-chain fatty acids.Future are needed decipher link specific patterns relation disease frameworks.

Язык: Английский

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Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

Nutrients, Год журнала: 2022, Номер 14(23), С. 5080 - 5080

Опубликована: Ноя. 29, 2022

Obesity is a chronic and relapsing public health problem with an extensive list of associated comorbidities. The worldwide prevalence obesity has nearly tripled over the last five decades continues to pose serious threat wider society wellbeing future generations. pathogenesis complex but diet plays key role in onset progression disease. human changed drastically across globe, estimate that approximately 72% calories consumed today come from foods were not part our ancestral diets are compatible metabolism. Additionally, multiple nutrient-independent factors, e.g., cost, accessibility, behaviours, culture, education, work commitments, knowledge societal set-up, influence food choices eating patterns. Much research been focused on ‘what eat’ or ‘how much reduce burden, increasingly evidence indicates ‘when fundamental Aligning feeding patterns 24-h circadian clock regulates wide range physiological behavioural processes health-promoting effects anti-obesity being major part. This article explores current understanding interactions between body clocks, bioactive dietary components less appreciated meal timings energy homeostasis obesity.

Язык: Английский

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Nutrient timing and metabolic regulation

The Journal of Physiology, Год журнала: 2022, Номер 600(6), С. 1299 - 1312

Опубликована: Янв. 18, 2022

Abstract Daily (circadian) rhythms coordinate our physiology and behaviour with regular environmental changes. Molecular clocks in peripheral tissues (e.g. liver, skeletal muscle adipose) give rise to macronutrient metabolism, appetite regulation the components of energy balance such that bodies can align periodic delivery nutrients ongoing metabolic requirements. The timing meals both absolute terms (i.e. relative clock time) other daily events) is therefore relevant metabolism health. Experimental manipulation feeding–fasting cycles advance understanding effect on Such studies have extended overnight fast by breakfast omission revealed morning fasting alter response subsequent later day, whilst also eliciting compensatory behavioural responses reduced physical activity). Similarly, restricting intake via alternate‐day has potential elicit a reduction activity, so undermine weight‐loss efforts preserve body fat stores). Interrupting usual (and sleep cycle) nocturnal feeding been examined further research needed understand importance this period for either nutritional intervention or withdrawal. In summary, it important dietary guidelines human health consider nutrient when we eat) alongside conventional focus quantity quality how much eat what eat). image

Язык: Английский

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Precision Nutrition: The Hype Is Exceeding the Science and Evidentiary Standards Needed to Inform Public Health Recommendations for Prevention of Chronic Disease

Annual Review of Nutrition, Год журнала: 2023, Номер 43(1), С. 385 - 407

Опубликована: Авг. 21, 2023

As dietary guidance for populations shifts from preventing deficiency disorders to chronic disease risk reduction, the biology supporting such becomes more complex due multifactorial profile of and inherent population heterogeneity in diet–disease relationship. Diet is a primary driver risk, population-based should account individual responses. Cascading effects on evidentiary standards are not straightforward. Precision remains consideration prevent through identification subgroups with unique nutritional needs. Reducing diet requires greater precision ( a) establishing essential nutrient needs throughout life cycle both health disease; b) considering nutrients other food substances metabolic, immunological, inflammatory, physiological responses healthy aging; c) eating behaviors. Herein we provide template guiding recommendations reducing diseases heterogenous populations.

Язык: Английский

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