Biomolecules,
Год журнала:
2024,
Номер
14(6), С. 673 - 673
Опубликована: Июнь 8, 2024
One
of
the
biggest
problems
in
treatment
idiopathic
Parkinson’s
disease
is
lack
new
drugs
that
slow
its
progression.
L-Dopa
remains
star
drug
this
disease,
although
it
induces
severe
side
effects.
The
failure
clinical
studies
with
depends
on
use
preclinical
models
based
neurotoxins
do
not
represent
what
happens
since
they
induce
rapid
and
expansive
neurodegeneration.
We
have
recently
proposed
a
single-neuron
degeneration
model
for
requires
years
to
accumulate
enough
lost
neurons
onset
motor
symptoms.
This
excessive
formation
aminochrome
during
neuromelanin
synthesis
surpass
neuroprotective
action
enzymes
DT-diaphorase
glutathione
transferase
M2-2,
which
prevent
neurotoxic
effects
aminochrome.
Although
an
effect,
stereotaxic
injection
endogenous
neurotoxin
cannot
be
used
generate
animal.
Therefore,
aim
review
evaluate
strategies
pharmacologically
increasing
expression
DT
diaphorase
GSTM2-2
molecules
vesicular
monoamine
transporter
2,
such
as
pramipexole.
Translational Neurodegeneration,
Год журнала:
2022,
Номер
11(1)
Опубликована: Дек. 12, 2022
Abstract
Extracellular
vesicles
(EVs)
are
small
bilipid
layer-enclosed
that
can
be
secreted
by
all
tested
types
of
brain
cells.
Being
a
key
intercellular
communicator,
EVs
have
emerged
as
contributor
to
the
pathogenesis
various
neurodegenerative
diseases
(NDs)
including
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis,
and
Huntington’s
disease
through
delivery
bioactive
cargos
within
central
nervous
system
(CNS).
Importantly,
CNS
cell-derived
purified
via
immunoprecipitation,
EV
with
altered
levels
been
identified
potential
biomarkers
for
diagnosis
prognosis
NDs.
Given
essential
impact
on
NDs,
pathological
considered
therapeutic
targets
effects
utilized
agents
or
drug
platforms
treatment
In
this
review,
we
focus
recent
research
progress
roles
released
from
cells
in
summarize
findings
identify
CNS-derived
diagnose
comprehensively
discuss
promising
targets,
agents,
systems
treating
together
current
concerns
challenges
basic
clinical
applications
regarding
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3061 - 3061
Опубликована: Фев. 4, 2023
Exosome,
a
subpopulation
of
extracellular
vesicles,
plays
diverse
roles
in
various
biological
processes.
As
one
the
most
abundant
components
exosomes,
exosomal
proteins
have
been
revealed
to
participate
development
many
diseases,
such
as
carcinoma,
sarcoma,
melanoma,
neurological
disorders,
immune
responses,
cardiovascular
and
infection.
Thus,
understanding
functions
mechanisms
potentially
assists
clinical
diagnosis
targeted
delivery
therapies.
However,
current
knowledge
about
function
application
is
still
limited.
In
this
review,
we
summarize
classification
proteins,
exosome
biogenesis
disease
development,
well
applications.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3321 - 3321
Опубликована: Фев. 7, 2023
Neurodegenerative
disorders
are
characterised
by
progressive
neuron
loss
in
specific
brain
areas.
The
most
common
Alzheimer’s
disease
and
Parkinson’s
disease;
both
cases,
diagnosis
is
based
on
clinical
tests
with
limited
capability
to
discriminate
between
similar
neurodegenerative
detect
the
early
stages
of
disease.
It
that
time
a
patient
diagnosed
disease,
level
neurodegeneration
already
severe.
Thus,
it
critical
find
new
diagnostic
methods
allow
earlier
more
accurate
detection.
This
study
reviews
available
for
diseases
potentially
interesting
technologies.
Neuroimaging
techniques
widely
used
practice,
such
as
magnetic
resonance
imaging
(MRI)
positron
emission
tomography
(PET)
have
significantly
improved
quality.
Identifying
biomarkers
peripheral
samples
blood
or
cerebrospinal
fluid
major
focus
current
research
diseases.
discovery
good
markers
could
preventive
screening
identify
asymptomatic
process.
These
methods,
combination
artificial
intelligence,
contribute
generation
predictive
models
will
help
clinicians
diagnosis,
stratification,
prognostic
assessment
patients,
leading
improvements
treatment
quality
life.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7137 - 7164
Опубликована: Июль 1, 2024
Abstract:
Exosomes
emerge
from
endosomal
invagination
and
range
in
size
30
to
200
nm.
contain
diverse
proteins,
lipids,
nucleic
acids,
which
can
indicate
the
state
of
various
physiological
pathological
processes.
Studies
have
revealed
remarkable
clinical
potential
exosomes
diagnosing
prognosing
multiple
diseases,
including
cancer,
cardiovascular
disorders,
neurodegenerative
conditions.
also
be
engineered
deliver
their
cargo
a
specific
target.
However,
further
advancements
are
imperative
optimize
exosomes'
diagnostic
therapeutic
capabilities
for
practical
implementation
settings.
This
review
highlights
applications,
emphasizing
engineering
through
simple
incubation,
biological,
click
chemistry
techniques.
Additionally,
loading
agents
onto
exosomes,
utilizing
passive
active
strategies,
exploring
hybrid
artificial
discussed.
Keywords:
exosome,
drug
delivery,
diagnostics,
therapeutics
Molecular Aspects of Medicine,
Год журнала:
2024,
Номер
99, С. 101302 - 101302
Опубликована: Авг. 1, 2024
Modern
methods
of
molecular
diagnostics
and
therapy
have
revolutionized
the
field
medicine
in
recent
years
by
providing
more
precise
effective
tools
for
detecting
treating
diseases.
This
progress
includes
a
growing
exploration
body's
secreted
vesicles,
known
as
extracellular
vesicles
(EVs),
both
diagnostic
therapeutic
purposes.
EVs
are
heterogeneous
population
lipid
bilayer
almost
every
cell
type
studied
so
far.
They
detected
body
fluids
conditioned
culture
media
from
living
cells.
play
crucial
role
communication
between
cells
organs,
locally
over
long
distances.
recognized
their
ability
to
transport
endogenous
RNA
proteins
cells,
including
messenger
(mRNA),
microRNA
(miRNA),
misfolded
neurodegenerative
proteins,
several
other
biomolecules.
review
explores
dual
utilization
EVs,
serving
not
only
purposes
but
also
platform
delivering
molecules
tissues.
Through
an
composition,
biogenesis,
selective
cargo
packaging,
we
elucidate
intricate
mechanisms
behind
via
highlighting
potential
use
applications.
Finally,
it
addresses
challenges
outlines
prospective
directions
clinical
EVs.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 9373 - 9393
Опубликована: Сен. 1, 2024
Extracellular
vesicles
(EVs)
are
promising
tools
for
nanomedicine
and
nanobiotechnology.
The
purification
of
mammalian-derived
EVs
involves
intensive
processes,
their
therapeutic
application
raises
multiple
safety
regulatory
issues.
Plants
have
the
potential
to
serve
as
nonconventional
sources
therapeutically
relevant
EVs.
In
this
context,
we
recently
identified
hairy
roots
(HRs)
medicinal
plants
a
novel
biotechnological
platform
produce
human
health.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(16), С. 9299 - 9299
Опубликована: Авг. 18, 2022
Neurodegenerative
diseases
such
as
amyotrophic
lateral
sclerosis
(ALS)
and
Parkinson’s
disease
(PD)
are
both
characterized
by
pathogenic
protein
aggregates
that
correlate
with
the
progressive
degeneration
of
neurons
loss
behavioral
functions.
Both
lack
biomarkers
for
diagnosis
treatment
efficacy.
Proteomics
is
an
unbiased
quantitative
tool
capable
high
throughput
quantitation
thousands
proteins
from
minimal
sample
volumes.
We
review
recent
proteomic
studies
in
human
tissues,
plasma,
cerebrospinal
fluid
(CSF),
exosomes
ALS
PD
identify
potential
utility
biomarkers.
Further,
we
disease-related
post-translational
modifications
key
TDP43
α-synuclein
studies,
which
may
serve
compare
relative
absolute
approaches
biomarker
discuss
technological
advancements
suitable
early-diagnosis
efficacy
these
diseases.
