Disorders of Endogenous and Exogenous Antioxidants in Neurological Diseases DOI Creative Commons
Izabela Korczowska-Łącka, Bartosz Słowikowski, Thomas Piekut

и другие.

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1811 - 1811

Опубликована: Сен. 29, 2023

In diseases of the central nervous system, such as Alzheimer's disease (AD), Parkinson's (PD), stroke, amyotrophic lateral sclerosis (ALS), Huntington's (HD), and even epilepsy migraine, oxidative stress load commonly surpasses endogenous antioxidative capacity. While processes have been robustly implicated in pathogenesis these diseases, significance particular antioxidants, both especially exogenous, maintaining redox homeostasis requires further research. Among enzymes catalase, superoxide dismutase, glutathione peroxidase are to disabling free radicals, thereby preventing damage cellular lipids, proteins, nucleic acids. Whether supplementation with endogenously occurring antioxidant compounds melatonin carries any benefit, however, remains equivocal. Similarly, while health benefits certain exogenous including ascorbic acid (vitamin C), carotenoids, polyphenols, sulforaphanes, anthocyanins touted, their clinical efficacy effectiveness neurological contexts need be more defined. Here, we review current literature on mechanisms mitigating comment possible benefit most common antioxidants AD, PD, ALS, HD, epilepsy, migraine. We selected a basically neurodegenerative nature.

Язык: Английский

GPX4, ferroptosis, and diseases DOI Open Access

Wangzheqi Zhang,

Yang Liu,

Liao Yan

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116512 - 116512

Опубликована: Апрель 3, 2024

GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing significant role maintaining the redox homeostasis within body. Ferroptosis, form of iron-dependent non-apoptotic cell death, has gained considerable attention recent years due to its involvement multiple pathological processes. is closely associated with ferroptosis functions primary inhibitor this process. Together, contribute pathophysiology several diseases, including sepsis, nervous system ischemia reperfusion injury, cardiovascular cancer. This review comprehensively explores roles impacts development progression these aim providing insights for identifying potential therapeutic strategies future.

Язык: Английский

Процитировано

58
The Vitamin D Receptor as a Potential Target for the Treatment of Age-Related Neurodegenerative Diseases Such as Alzheimer’s and Parkinson’s Diseases: A Narrative Review DOI Creative Commons
Władysław Lasoń, Danuta Jantas, Monika Leśkiewicz

и другие.

Cells, Год журнала: 2023, Номер 12(4), С. 660 - 660

Опубликована: Фев. 19, 2023

The vitamin D receptor (VDR) belongs to the nuclear superfamily of transcription factors. VDR is expressed in diverse brain regions and has been implicated neuroprotective, antiaging, prosurvival, anti-inflammatory action D. Accordingly, a relationship between insufficiency susceptibility neurodegenerative diseases suggested. However, due multitargeted mechanisms its often overlapping genomic nongenomic effects, role pathologies remains obscure. In this narrative review, we present progress deciphering molecular mechanism VDR-mediated effects on prosurvival signaling pathway activity within central nervous system. line with concept neurovascular unit pathomechanisms diseases, discussion regulating immune vascular systems also included. Next, discuss results preclinical clinical studies evaluating significance status efficacy supplementation treatment Parkinson’s Alzheimer’s emphasizing possible these phenomena. Finally, associations some polymorphisms higher risks severity disorders are briefly summarized.

Язык: Английский

Процитировано

57
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects DOI Creative Commons

Qin Ru,

Yusheng Li,

Lin Chen

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Язык: Английский

Процитировано

56
An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis DOI Creative Commons
Jong Woo Kim, Ji-Yoon Lee,

Mihee Oh

и другие.

Experimental & Molecular Medicine, Год журнала: 2023, Номер 55(8), С. 1620 - 1631

Опубликована: Авг. 23, 2023

Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue damage in various human diseases, such as cardiovascular neurodegeneration, liver disease, cancer. Although polyunsaturated fatty acids (PUFAs) membrane phospholipids are preferentially oxidized, saturated/monounsaturated (SFAs/MUFAs) also influence peroxidation ferroptosis. In this review, we first explain how cells differentially synthesize SFA/MUFAs PUFAs they control acid pools via uptake β-oxidation, impacting Furthermore, discuss stored different lipids, diacyl or ether with head groups; triglycerides; cholesterols. Moreover, these released from molecules. summary, provide an integrated view the diverse dynamic metabolic processes context ferroptosis revisiting lipidomic studies. Thus, review development therapeutic strategies for ferroptosis-related diseases.

Язык: Английский

Процитировано

54
Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications DOI Creative Commons
Oke-Oghene Philomena Akpoveso, Emeka Emmanuel Ubah,

Gideon Obasanmi

и другие.

Antioxidants, Год журнала: 2023, Номер 12(1), С. 123 - 123

Опубликована: Янв. 4, 2023

The global prevalence of diabetes continues to increase partly due rapid urbanization and an in the aging population. Consequently, this is associated with a parallel diabetic vascular complications which significantly worsen burden diabetes. For these complications, there still unmet need for safe effective alternative/adjuvant therapeutic interventions. There also increasing urge options come from natural products such as plants. Hyperglycemia-induced oxidative stress central development complications. Furthermore, stress-induced inflammation insulin resistance are endothelial damage progression Human animal studies have shown that polyphenols could reduce stress, hyperglycemia, prevent including retinopathy, nephropathy, peripheral neuropathy. Part effects attributed their modulatory effect on endogenous antioxidant systems. This review attempts summarize established systems literature. Moreover, potential strategies harnessing benefits discussed.

Язык: Английский

Процитировано

50
Iron imbalance in neurodegeneration DOI Creative Commons
Sonia Levi, Maddalena Ripamonti, Andrea Stefano Moro

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер 29(4), С. 1139 - 1152

Опубликована: Янв. 12, 2024

Iron is an essential element for the development and functionality of brain, anomalies in its distribution concentration brain tissue have been found to be associated with most frequent neurodegenerative diseases. When magnetic resonance techniques allowed iron quantification vivo, it was confirmed that alteration homeostasis a common feature many However, whether main actor process, or consequence degenerative process still open question. Because different iron-related pathogenic mechanisms are specific distinctive diseases, identifying molecular various pathologies could represent way clarify this complex topic. Indeed, both overload deficiency profound consequences on cellular functioning, contribute neuronal death processes manners, such as promoting oxidative damage, loss membrane integrity, proteostasis, mitochondrial dysfunction. In review, attempt elucidate dyshomeostasis health, we summarize pathological couple death.

Язык: Английский

Процитировано

50
COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells DOI Creative Commons
Stanislovas S. Jankauskas, Urna Kansakar, Celestino Sardu

и другие.

Antioxidants, Год журнала: 2023, Номер 12(2), С. 326 - 326

Опубликована: Янв. 31, 2023

Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought investigate impact on lipid peroxidation ferroptosis human cells. We hypothesized that oxidative induced by cells could be linked outcome. Thus, collected serum from patients hospital admission, incubated sera with cells, comparing effects generation reactive oxygen species (ROS) between who survived did not survive. found non-survivors significantly increased peroxidation. Moreover, markedly regulated expression levels main markers ferroptosis, including GPX4, SLC7A11, FTH1, SAT1, a response was rescued silencing TNFR1 Taken together, our data indicate survive triggers

Язык: Английский

Процитировано

48
Hydroxyl radical generations form the physiologically relevant Fenton-like reactions DOI
Zhongwei Zhao

Free Radical Biology and Medicine, Год журнала: 2023, Номер 208, С. 510 - 515

Опубликована: Сен. 17, 2023

Язык: Английский

Процитировано

43
NRF2 Deficiency Promotes Ferroptosis of Astrocytes Mediated by Oxidative Stress in Alzheimer’s Disease DOI
Zhi Tang,

Zhuyi Chen,

Min Guo

и другие.

Molecular Neurobiology, Год журнала: 2024, Номер 61(10), С. 7517 - 7533

Опубликована: Фев. 24, 2024

Язык: Английский

Процитировано

24
Ferroptosis inhibitors: past, present and future DOI Creative Commons
Lei Zhang, Yi Luo, Yang Xiang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Язык: Английский

Процитировано

20