Effects of dietary fibre on metabolic health and obesity

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2024, Номер 21(5), С. 301 - 318

Опубликована: Фев. 7, 2024

Язык: Английский

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Interplay between the brain and adipose tissue: a metabolic conversation

EMBO Reports, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Язык: Английский

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Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(8)

Опубликована: Фев. 14, 2025

Mammalian opsin 3 (OPN3) is a member of the family G-protein-coupled receptors with ambiguous light sensitivity. OPN3 was first identified in brain (and named encephalopsin) and subsequently found to be expressed other tissues. In adipocytes, necessary for responses that modulate lipolysis glucose uptake, while human skin melanocytes regulates pigmentation light-independent manner. Despite its initial discovery brain, functional mechanisms remain elusive. Here, we investigated molecular mechanism function paraventricular nucleus (PVN) hypothalamus. We show Opn3 coexpressed melanocortin 4 receptor (Mc4r) population PVN neurons, where it negatively MC4R-mediated cAMP signaling specific Gαi/o-dependent Under baseline conditions, via Gαi/o potentiates activity inward rectifying Kir7.1 channel, previously shown closed response agonist-mediated activation MC4R Gαs-independent mice, Mc4r-expressing neurons food consumption. Our results reveal mechanistic insight into hypothalamus, uncovering unique by which functions potentiate regulate signaling, thereby promoting intake.

Язык: Английский

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Modulated regulation of the stress-feeding-growth neuroendocrine cascade in Chinese seabass (Lateolabrax maculatus) under temperature and salinity changes

Environmental Research, Год журнала: 2025, Номер unknown, С. 121151 - 121151

Опубликована: Фев. 1, 2025

Язык: Английский

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The melanocortin‐4 receptor pathway and the emergence of precision medicine in obesity management

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(S2), С. 46 - 63

Опубликована: Март 19, 2024

Abstract Over the past few decades, there has been a global surge in prevalence of obesity, rendering it globally recognized epidemic. Contrary to simply being medical condition, obesity is an intricate disease with multifactorial aetiology. Understanding precise cause remains challenge; nevertheless, seems be complex interplay among biological, psychosocial and behavioural factors. Studies on genetic factors have revealed several pathways brain that play crucial role food intake regulation. The best characterized pathway, thus far, leptin–melanocortin from which disruptions are responsible for majority monogenic disorders. effectiveness conservative lifestyle interventions addressing limited. Therefore, complement management strategy pharmacological surgical options. Emphasis placed developing drugs aimed at replacing absent signals, goal restoring pathway. In both polygenic forms outcomes differ across various interventions, likely due multifaceted nature disease. This underscores need explore alternative therapeutic strategies can mitigate this heterogeneity. Precision medicine regarded as powerful tool address concern, values understanding underlying abnormality triggering provides tailored treatment accordingly. would assist optimizing current approaches even aid development novel treatments capable more effectively managing

Язык: Английский

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Hypothalamic GABAergic Neurons Expressing Cellular Retinoic Acid Binding Protein 1 (CRABP1) Are Sensitive to Metabolic Status and Liraglutide in Male Mice

Neuroendocrinology, Год журнала: 2024, Номер 114(7), С. 681 - 697

Опубликована: Янв. 1, 2024

<b><i>Introduction:</i></b> Owing to their privileged anatomical location, neurons of the arcuate nucleus hypothalamus (ARC) play critical roles in sensing and responding metabolic signals such as leptin glucagon-like peptide 1 (GLP-1). In addition well-known proopiomelanocortin (POMC)- agouti-related (AgRP)-expressing neurons, subpopulations GABAergic are emerging key regulators energy balance. However, precise identity these is still elusive. Here, we identified characterized molecular signature a novel population ARC expressing <i>Cellular retinoic acid binding protein 1</i> (<i>Crabp1</i>). <b><i>Methods:</i></b> Using combination immunohistochemistry situ hybridization techniques, investigated expression <i>Crabp1</i> across mouse brain <i>Crabp1</i>^ARC neurons. We also determined whether sensitive fasting, leptin, GLP1R agonism by assessing cFOS immunoreactivity marker neuronal activity. <b><i>Results:</i></b> represent robustly enriched distinct from prototypical melanocortin <i>Crabp1</i>^<i>ARC</i> overlap with three yet uncharacterized <i>Htr3b</i>, <i>Tbx19</i>, <i>Tmem215</i>. Notably, express receptors for hormones activity modulated nutritional state agonism. <b><i>Conclusion:</i></b> heterogeneous status.

Язык: Английский

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Obesity and the nervous system

Obesity and metabolism, Год журнала: 2024, Номер 21(1), С. 68 - 78

Опубликована: Март 6, 2024

The article discusses certain aspects of the relationship between neurological diseases and metabolic disorders that are extremely relevant in connection with pandemic spread obesity. pathogenesis damage to nervous system (NS) is considered detail. influence main factors on development cerebrovascular (CVD), incl. neuroinflammation, changes hemostasis, etc. demonstrated. problem cognitive dysfunction against background obesity due formation atrophic processes brain structures highlighted. Modern possibilities evaluation modulation eating behavior stimulation using functional magnetic resonance imaging (fMRI) navigational rhythmic transcranial (rTMS) described. cerebrometabolic health presented as a continuum cerebral disturbances. mechanisms interaction two most important systems body allow us consider occur them an integral neuroendocrine alteration.

Язык: Английский

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Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Опубликована: Май 9, 2024

Thyrotropin releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food-intake not well understood. We review data show peripheral injection TRH generally produces a transient anorexic effect, discuss pathways might initiate this and explain its short half-life. In addition, central administration can produce or orexigenic effects, depending site injection, are likely due to interaction with receptor 1. Anorexic most notable when injected into hypothalamus nucleus accumbens, while effect has only been detected brain stem. Functional evidence suggests neurons prime candidate vectors for action include caudal raphe nuclei projecting dorsal motor vagus, possibly from tuberal lateral tuberomammillary nuclei. For other neurons, anatomical physiological context impact in each synaptic domain still poorly The manipulation expression well-defined neuron types will facilitate discovery role control scene.

Язык: Английский

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Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins

Journal of Endocrinological Investigation, Год журнала: 2024, Номер unknown

Опубликована: Июнь 15, 2024

Язык: Английский

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History and future of leptin: Discovery, regulation and signaling

Metabolism, Год журнала: 2024, Номер 161, С. 156026 - 156026

Опубликована: Сен. 7, 2024

Язык: Английский

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