Vitamins and hormones, Journal Year: 2024, Volume and Issue: unknown, P. 305 - 362
Published: Aug. 22, 2024
Language: Английский
Vitamins and hormones, Journal Year: 2024, Volume and Issue: unknown, P. 305 - 362
Published: Aug. 22, 2024
Language: Английский
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(5), P. 301 - 318
Published: Feb. 7, 2024
Language: Английский
Citations
36EMBO Reports, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Language: Английский
Citations
7Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(8)
Published: Feb. 14, 2025
Mammalian opsin 3 (OPN3) is a member of the family G-protein-coupled receptors with ambiguous light sensitivity. OPN3 was first identified in brain (and named encephalopsin) and subsequently found to be expressed other tissues. In adipocytes, necessary for responses that modulate lipolysis glucose uptake, while human skin melanocytes regulates pigmentation light-independent manner. Despite its initial discovery brain, functional mechanisms remain elusive. Here, we investigated molecular mechanism function paraventricular nucleus (PVN) hypothalamus. We show Opn3 coexpressed melanocortin 4 receptor (Mc4r) population PVN neurons, where it negatively MC4R-mediated cAMP signaling specific Gαi/o-dependent Under baseline conditions, via Gαi/o potentiates activity inward rectifying Kir7.1 channel, previously shown closed response agonist-mediated activation MC4R Gαs-independent mice, Mc4r-expressing neurons food consumption. Our results reveal mechanistic insight into hypothalamus, uncovering unique by which functions potentiate regulate signaling, thereby promoting intake.
Language: Английский
Citations
1Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121151 - 121151
Published: Feb. 1, 2025
Language: Английский
Citations
1Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(S2), P. 46 - 63
Published: March 19, 2024
Abstract Over the past few decades, there has been a global surge in prevalence of obesity, rendering it globally recognized epidemic. Contrary to simply being medical condition, obesity is an intricate disease with multifactorial aetiology. Understanding precise cause remains challenge; nevertheless, seems be complex interplay among biological, psychosocial and behavioural factors. Studies on genetic factors have revealed several pathways brain that play crucial role food intake regulation. The best characterized pathway, thus far, leptin–melanocortin from which disruptions are responsible for majority monogenic disorders. effectiveness conservative lifestyle interventions addressing limited. Therefore, complement management strategy pharmacological surgical options. Emphasis placed developing drugs aimed at replacing absent signals, goal restoring pathway. In both polygenic forms outcomes differ across various interventions, likely due multifaceted nature disease. This underscores need explore alternative therapeutic strategies can mitigate this heterogeneity. Precision medicine regarded as powerful tool address concern, values understanding underlying abnormality triggering provides tailored treatment accordingly. would assist optimizing current approaches even aid development novel treatments capable more effectively managing
Language: Английский
Citations
6Neuroendocrinology, Journal Year: 2024, Volume and Issue: 114(7), P. 681 - 697
Published: Jan. 1, 2024
<b><i>Introduction:</i></b> Owing to their privileged anatomical location, neurons of the arcuate nucleus hypothalamus (ARC) play critical roles in sensing and responding metabolic signals such as leptin glucagon-like peptide 1 (GLP-1). In addition well-known proopiomelanocortin (POMC)- agouti-related (AgRP)-expressing neurons, subpopulations GABAergic are emerging key regulators energy balance. However, precise identity these is still elusive. Here, we identified characterized molecular signature a novel population ARC expressing <i>Cellular retinoic acid binding protein 1</i> (<i>Crabp1</i>). <b><i>Methods:</i></b> Using combination immunohistochemistry situ hybridization techniques, investigated expression <i>Crabp1</i> across mouse brain <i>Crabp1</i><sup>ARC</sup> neurons. We also determined whether sensitive fasting, leptin, GLP1R agonism by assessing cFOS immunoreactivity marker neuronal activity. <b><i>Results:</i></b> represent robustly enriched distinct from prototypical melanocortin <i>Crabp1</i><sup><i>ARC</i></sup> overlap with three yet uncharacterized <i>Htr3b</i>, <i>Tbx19</i>, <i>Tmem215</i>. Notably, express receptors for hormones activity modulated nutritional state agonism. <b><i>Conclusion:</i></b> heterogeneous status.
Language: Английский
Citations
5Obesity and metabolism, Journal Year: 2024, Volume and Issue: 21(1), P. 68 - 78
Published: March 6, 2024
The article discusses certain aspects of the relationship between neurological diseases and metabolic disorders that are extremely relevant in connection with pandemic spread obesity. pathogenesis damage to nervous system (NS) is considered detail. influence main factors on development cerebrovascular (CVD), incl. neuroinflammation, changes hemostasis, etc. demonstrated. problem cognitive dysfunction against background obesity due formation atrophic processes brain structures highlighted. Modern possibilities evaluation modulation eating behavior stimulation using functional magnetic resonance imaging (fMRI) navigational rhythmic transcranial (rTMS) described. cerebrometabolic health presented as a continuum cerebral disturbances. mechanisms interaction two most important systems body allow us consider occur them an integral neuroendocrine alteration.
Language: Английский
Citations
3Published: May 9, 2024
Thyrotropin releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food-intake not well understood. We review data show peripheral injection TRH generally produces a transient anorexic effect, discuss pathways might initiate this and explain its short half-life. In addition, central administration can produce or orexigenic effects, depending site injection, are likely due to interaction with receptor 1. Anorexic most notable when injected into hypothalamus nucleus accumbens, while effect has only been detected brain stem. Functional evidence suggests neurons prime candidate vectors for action include caudal raphe nuclei projecting dorsal motor vagus, possibly from tuberal lateral tuberomammillary nuclei. For other neurons, anatomical physiological context impact in each synaptic domain still poorly The manipulation expression well-defined neuron types will facilitate discovery role control scene.
Language: Английский
Citations
3Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: unknown
Published: June 15, 2024
Language: Английский
Citations
3Metabolism, Journal Year: 2024, Volume and Issue: 161, P. 156026 - 156026
Published: Sept. 7, 2024
Language: Английский
Citations
3