Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics

Journal of Cosmetic Dermatology, Год журнала: 2021, Номер 20(12), С. 3759 - 3781

Опубликована: Ноя. 6, 2021

Androgenetic alopecia (AGA) is the most common form of hair loss consisting a characteristic receding frontal hairline in men and diffuse thinning women, with retention, can impact an individual's quality life. The condition primarily mediated by 5-alpha-reductase dihydrotestosterone (DHT) which causes follicles to undergo miniaturization shortening successive anagen cycles. Although variety medical, surgical, light-based nutraceutical treatment options are available slow or reverse progression AGA, it be challenging select appropriate therapies for this chronic condition.To highlight androgenetic taking into consideration efficacy, side effect profiles, practicality (compliance), costs help clinicians offer ethically regimens their patients.A literature search was conducted using electronic databases (Medline, PubMed, Embase, CINAHL, EBSCO) textbooks, addition authors' other practitioners' clinical experiences treating alopecia, findings presented here.Although topical minoxidil, oral finasteride, low-level light therapy only FDA-approved treat they just fraction available, including modalities, hormonal therapies, nutraceuticals, PRP exosome treatments, transplantation.Androgenetic remains as selection involves ethical, evidence-based decision-making each individual patient's needs, compliance, budget, extent loss, aesthetic goals, independent potential financial benefits practitioners.

Язык: Английский

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Androgenetic alopecia: An update

JAAD International, Год журнала: 2023, Номер 13, С. 150 - 158

Опубликована: Июль 22, 2023

Androgenetic alopecia (AGA) is the most common nonscarring and characterised by distinct gradual patterned hair loss. AGA mediated genetic predisposition excessive follicular sensitivity to androgens, mainly in males, leading progressive conversion of scalp terminal into vellus hair. Although highly prevalent, it not fatal but may have a severe psychosocial impact, especially on females younger males. Significant advances been made understanding AGA's epidemiology pathophysiology, only 2 drugs remain approved FDA - finasteride minoxidil. Prolonged use these drugs, prerequisite for enhanced treatment response. However, this leads poor medication adherence adverse effects from extended eg, "postfinasteride syndrome" which persists beyond stopping drug. Hence, there need research more effective alternative treatments AGA, with fewer side effects. This paper reviewed recent pathophysiology its options. The recently characterized structure type 2, 5-alpha reductase holds significance comprehending present prospective AGA.

Язык: Английский

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Injections of platelet‐rich plasma prepared by automatic blood cell separator combined with topical 5% minoxidil in the treatment of male androgenetic alopecia

Skin Research and Technology, Год журнала: 2023, Номер 29(7)

Опубликована: Июнь 20, 2023

Platelet-rich plasma (PRP) has been increasingly accepted as a potential therapy in the treatment of androgenetic alopecia (AGA), However, there remains dearth data on effectiveness PRP prepared by automatic blood cell separator with combination topical minoxidil for AGA.

Язык: Английский

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Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2023, Номер Volume 16, С. 1387 - 1406

Опубликована: Май 1, 2023

Abstract: Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women. Traditionally, topical minoxidil oral finasteride have been standard care yielding mixed results. New treatments such as Low-Level Laser Therapy (LLLT), microneedling, platelet-rich plasma (PRP), others extensively studied literature, purpose this review to provide a comprehensive discussion latest treatment methods their efficacy treating AGA. Novel therapies minoxidil, finasteride, spironolactone, botulinum toxin, stem cell therapy offer interesting alternatives for patients. In review, we present data from recent studies on clinical these treatments. Furthermore, new emerged, clinicians tested combination assess whether there may be synergistic relationship between multiple modalities. While has great increase available AGA, quality evidence varies greatly still need randomized double blinded trials adequately some PRP LLLT demonstrated encouraging results, standardized protocols are needed inform how use therapies. Given abundance therapeutic options, patients must weigh benefits risks each option Keywords: androgenetic alopecia, platelet rich plasma, microneedling

Язык: Английский

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Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial

Stem Cell Research & Therapy, Год журнала: 2023, Номер 14(1)

Опубликована: Авг. 21, 2023

Treatments for AGA have yet to produce satisfactory outcomes and may cause intolerable side effects. Recent studies reported that adipose tissue-derived stem cell conditioned media (ADSC-CM) could induce hair growth regeneration.To investigate the efficacy of ADSC-CM combined with minoxidil regeneration therapy in male AGA.This study lasted 6 weeks. Subjects were divided into two groups: concentrated non-concentrated ADSC-CM. Scalp was vertically half before intradermal injection administered from frontal region scalp toward vertex a 30G needle, spaced about 1 cm apart. Treatment received 2 ml ADSC-CM; other given NaCl 0.9% as placebo. Patients applied 5% twice daily post-injection. Improvements assessed using photographs trichoscan every weeks.Hair count, density, mean thickness increased significantly on both sides after weeks, while vellus rate decreased proportionally increase terminal rate. No statistically significant differences between treatment groups found. Minimum effects reported, subjects satisfied results.Combination be potential agent regrowth. Follow-up research extensive populations, longer duration, different design required confirm exact mechanisms growth.Clinicaltrials.gov, NCT05296863. Registered 25 March 2022-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05296863 .

Язык: Английский

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The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2023, Номер Volume 16, С. 603 - 612

Опубликована: Март 1, 2023

Introduction: Androgenetic alopecia (AGA) has negative impacts on both men and women in terms of appearance mental stress. Spironolactone is a synthetic aldosterone receptor antagonist known to stimulate hair growth been widely used by dermatologists treat AGA. Objective: To conduct systematic review evaluating the efficacy safety topical oral spironolactone AGA treatment. Methods: We searched PubMed, Embase, Cochrane Library, Web Science until October 23rd, 2022, for human studies treatment AGA, regardless doses routes. Results: retrieved 784 papers ultimately 7 articles matched our inclusion criteria comprised 618 patients (65 men, 553 women), 414 them received Oral ranged from 25mg 200mg daily, with vast majority between 80mg 110 mg. Dosage forms use include gels 1% solutions 5% twice daily. Both have shown recovery, but significantly fewer side effects suitable any gender. It showed better combination other therapies such as or minoxidil compared monotherapy. Conclusion: an effective safe androgenic which can enhance when combined conventional treatments minoxidil. Topical safer than administration male female patients, expected become common drug those who do not good response Furthermore, more high-quality clinical randomized controlled should be performed. Keywords: androgenetic alopecia, spironolactone, dosage, combine therapy, efficacy, adverse

Язык: Английский

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Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5703 - 5703

Опубликована: Март 16, 2023

Androgenic alopecia (AGA) is the most common type of hair loss, where local high concentrations dihydrotestosterone (DHT) in scalp cause progressive shrinkage follicles, eventually contributing to loss. Due limitations existing methods treat AGA, use multi-origin mesenchymal stromal cell-derived exosomes has been proposed. However, functions and mechanisms action secreted by adipose cells (ADSCs-Exos) AGA are still unclear. Using Cell Counting Kit-8 (CCK8) analysis, immunofluorescence staining, scratch assays, Western blotting, it was found that ADSC-Exos contributed proliferation, migration, differentiation dermal papilla (DPCs) up-regulated expression cyclin, β-catenin, versican, BMP2. also mitigated inhibitory effects DHT on DPCs down-regulated transforming growth factor-beta1 (TGF-β1) its downstream genes. Moreover, high-throughput miRNA sequencing bioinformatics analysis identified 225 genes were co-expressed ADSC-Exos; these, miR-122-5p highly enriched luciferase assays target SMAD3. carrying antagonized inhibition β-catenin versican vivo vitro, restored bulb size thickness, promoted normal follicles. So, enhanced regeneration follicles through TGF-β/SMAD3 axis. These results suggest a novel treatment option for AGA.

Язык: Английский

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A Comprehensive Review on Platelet-Rich Plasma Activation: A Key Player in Accelerating Skin Wound Healing

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 17, 2023

Platelet-rich plasma (PRP) activation is emerging as a promising and multifaceted tool for accelerating skin wound healing. This review extensively examines PRP's role in healing, focusing on its composition, mechanisms of action, methods, clinical applications. potential to enhance both chronic acute healing applications cosmetic aesthetic procedures are explored. Furthermore, this investigates safety concerns, including adverse reactions, infection risks, long-term implications. Looking the future, technologies, combination therapies, personalized medicine approaches, regulatory developments discussed, pointing towards an important transformative era regenerative medicine. With wide-ranging implications healthcare, PRP has become ubiquitous essential therapeutic option, improving patient outcomes reducing healthcare costs.

Язык: Английский

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Advances and applications of biomimetic biomaterials for endogenous skin regeneration

Bioactive Materials, Год журнала: 2024, Номер 39, С. 492 - 520

Опубликована: Май 30, 2024

Endogenous regeneration is becoming an increasingly important strategy for wound healing as it facilitates skin's own regenerative potential self-healing, thereby avoiding the risks of immune rejection and exogenous infection. However, currently applied biomaterials inducing endogenous skin are simplistic in their structure function, lacking ability to accurately mimic intricate tissue regulate disordered microenvironment. Novel biomimetic with precise structure, chemical composition, biophysical properties offer a promising avenue achieving perfect regeneration. Here, we outline recent advances materials induced from aspects structural functional mimicry, physiological process regulation, property design. Furthermore, novel techniques including situ reprograming, flexible electronic skin, artificial intelligence, single-cell sequencing, spatial transcriptomics, which have contribute development highlighted. Finally, prospects challenges further research application discussed. This review provides reference address clinical problems rapid high-quality

Язык: Английский

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Cardamonin-loaded liposomal formulation for improving percutaneous penetration and follicular delivery for androgenetic alopecia

Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(9), С. 2444 - 2460

Опубликована: Фев. 14, 2024

Язык: Английский

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