The Impact of Epidemiological Trends and Guideline Adherence on Candidemia-Associated Mortality: A 14-Year Study in Northeastern Italy

Journal of Fungi, Год журнала: 2025, Номер 11(5), С. 400 - 400

Опубликована: Май 21, 2025

Invasive candidiasis represents a major global health concern, with incidence and mortality rates expected to rise due medical advancements unavoidable risk factors. This retrospective, multicentric study was conducted in eight hospitals northeastern Italian region, enrolling adult patients diagnosed candidemia from 1 January 2018 31 December 2022. Epidemiological trends clinical characteristics were analyzed compared those prior regional (2009–2011), allowing fourteen-year comparative evaluation. A shift species distribution observed, decline Candida albicans (from 65.7% 57.8%) non-albicans species, particularly the parapsilosis complex 16.1% 18.2%). Guideline adherence assessed applying EQUAL score; scores ≥ than 11.5 independently associated improved in-hospital survival (HR 3.51, p < 0.001). Among individual score components, empiric echinocandin therapy central venous catheter removal correlated better outcomes. Centers routine infectious disease (ID) consultations showed higher adherence, reinforcing value of specialist involvement. These findings support local epidemiological management practice surveillance program adoption address context-specific gaps, promote best practices BSI management—as expanded ID education programs—and, ultimately, reduce candidemia-related rates.

Язык: Английский

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Factors influencing outcomes in candidemia: A retrospective study of patients in a Swedish county

Mycoses, Год журнала: 2024, Номер 67(7)

Опубликована: Июнь 27, 2024

Candidemia is a diverse condition and associated with broad spectrum of clinical presentation. As mortality high, timely diagnosis candidemia start correct therapeutic treatment are essential.

Язык: Английский

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Necrotizing pancreatitis with invasive candidiasis and candidemia due to Candida albicans and pan-echinocandin-resistant Candida glabrata

Medical Mycology Case Reports, Год журнала: 2024, Номер 43, С. 100636 - 100636

Опубликована: Фев. 20, 2024

We report on a 64-year-old man with necrotizing pancreatitis related, invasive candidiasis, and candidemia. Despite multidisciplinary management including antifungal therapy, endoscopic interventions surgery, the patients' infection progressed lead to colon perforation, retroperitoneal abscess formation, polymicrobial bloodstream infections. Resistance echinocandins in

Язык: Английский

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Which trial do we need? Shorter antifungal treatment for candidemia – challenging the 14-day dogma

Clinical Microbiology and Infection, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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