Which trial do we need? Shorter antifungal treatment for candidemia – challenging the 14-day dogma DOI
Nico Bekaan, Oliver A. Cornely, Tim Friede

et al.

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

The Impact of Epidemiological Trends and Guideline Adherence on Candidemia-Associated Mortality: A 14-Year Study in Northeastern Italy DOI Creative Commons

Fabiana Dellai,

Alberto Pagotto, Francesco Sbrana

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(5), P. 400 - 400

Published: May 21, 2025

Invasive candidiasis represents a major global health concern, with incidence and mortality rates expected to rise due medical advancements unavoidable risk factors. This retrospective, multicentric study was conducted in eight hospitals northeastern Italian region, enrolling adult patients diagnosed candidemia from 1 January 2018 31 December 2022. Epidemiological trends clinical characteristics were analyzed compared those prior regional (2009–2011), allowing fourteen-year comparative evaluation. A shift species distribution observed, decline Candida albicans (from 65.7% 57.8%) non-albicans species, particularly the parapsilosis complex 16.1% 18.2%). Guideline adherence assessed applying EQUAL score; scores ≥ than 11.5 independently associated improved in-hospital survival (HR 3.51, p < 0.001). Among individual score components, empiric echinocandin therapy central venous catheter removal correlated better outcomes. Centers routine infectious disease (ID) consultations showed higher adherence, reinforcing value of specialist involvement. These findings support local epidemiological management practice surveillance program adoption address context-specific gaps, promote best practices BSI management—as expanded ID education programs—and, ultimately, reduce candidemia-related rates.

Language: Английский

Citations

0
Factors influencing outcomes in candidemia: A retrospective study of patients in a Swedish county DOI Creative Commons
Hanna Thorold Klingspor, Anita Hällgren

Mycoses, Journal Year: 2024, Volume and Issue: 67(7)

Published: June 27, 2024

Candidemia is a diverse condition and associated with broad spectrum of clinical presentation. As mortality high, timely diagnosis candidemia start correct therapeutic treatment are essential.

Language: Английский

Citations

3
Necrotizing pancreatitis with invasive candidiasis and candidemia due to Candida albicans and pan-echinocandin-resistant Candida glabrata DOI Creative Commons
Laman Rahimli, Jon Salmanton‐García, Philipp Kasper

et al.

Medical Mycology Case Reports, Journal Year: 2024, Volume and Issue: 43, P. 100636 - 100636

Published: Feb. 20, 2024

We report on a 64-year-old man with necrotizing pancreatitis related, invasive candidiasis, and candidemia. Despite multidisciplinary management including antifungal therapy, endoscopic interventions surgery, the patients' infection progressed lead to colon perforation, retroperitoneal abscess formation, polymicrobial bloodstream infections. Resistance echinocandins in

Language: Английский

Citations

1
Which trial do we need? Shorter antifungal treatment for candidemia – challenging the 14-day dogma DOI
Nico Bekaan, Oliver A. Cornely, Tim Friede

et al.

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

0