EBioMedicine,
Год журнала:
2021,
Номер
66, С. 103293 - 103293
Опубликована: Апрель 1, 2021
The
gut
microbiome
and
the
intestinal
immune
system
are
driving
contributors
to
inflammatory
bowel
diseases
(IBD).
Both
have
an
important
signalling
factor
in
common:
short-chain
fatty
acids
(SCFAs).
SCFAs
(acetate,
propionate
butyrate)
produced
by
bacterial
fermentation
exert
several
effects
on
host
metabolism
system.
This
review
provides
overview
of
current
knowledge
these
effects,
with
specific
focus
energy
metabolism,
barrier,
system,
disease
activity
IBD.
To
conclude,
more
research
is
needed
cross-feeding
mechanisms
microbiome,
as
well
therapeutic
potential
different
models.
Also
randomized
controlled
trials
prospective
cohort
studies
should
investigate
clinical
impact
SCFA
administration.
Nutrients,
Год журнала:
2023,
Номер
15(9), С. 2211 - 2211
Опубликована: Май 6, 2023
Short-chain
fatty
acids
(SCFAs)
play
a
key
role
in
health
and
disease,
as
they
regulate
gut
homeostasis
their
deficiency
is
involved
the
pathogenesis
of
several
disorders,
including
inflammatory
bowel
diseases,
colorectal
cancer,
cardiometabolic
disorders.
SCFAs
are
metabolites
specific
bacterial
taxa
human
microbiota,
production
influenced
by
foods
or
food
supplements,
mainly
prebiotics,
direct
fostering
these
taxa.
This
Review
provides
an
overview
SCFAs’
roles
functions,
SCFA-producing
bacteria,
from
microbiological
characteristics
taxonomy
to
biochemical
process
that
lead
release
SCFAs.
Moreover,
we
will
describe
potential
therapeutic
approaches
boost
levels
treat
different
related
diseases.
Clinical Nutrition,
Год журнала:
2022,
Номер
42(2), С. 61 - 75
Опубликована: Ноя. 2, 2022
Butyrate
is
a
key
energy
source
for
colonocytes
and
produced
by
the
gut
microbiota
through
fermentation
of
dietary
fiber.
histone
deacetylase
inhibitor
also
signals
three
G-protein
coupled
receptors.
It
clear
that
butyrate
has
an
important
role
in
gastrointestinal
health
levels
can
impact
both
host
microbial
functions
are
intimately
with
each
other.
Maintaining
optimal
improves
animal
models
supporting
colonocyte
function,
decreasing
inflammation,
maintaining
barrier,
promoting
healthy
microbiome.
shown
protective
actions
context
intestinal
diseases
such
as
inflammatory
bowel
disease,
graft-versus-host
disease
tract,
colon
cancer,
whereas
lower
and/or
microbes
which
responsible
producing
this
metabolite
associated
poorer
outcomes.
However,
clinical
efforts
to
increase
humans
reverse
these
negative
outcomes
have
generated
mixed
results.
This
article
discusses
our
current
understanding
molecular
mechanisms
action
focus
on
system,
links
between
factors,
currently
underway
apply
knowledge
gained
from
bench
bedside.
Cell Communication and Signaling,
Год журнала:
2022,
Номер
20(1)
Опубликована: Май 11, 2022
Inflammatory
bowel
disease
(IBD)
comprises
a
group
of
chronic
inflammatory
disorders
the
gastrointestinal
tract.
Accumulating
evidence
shows
that
development
IBD
is
always
accompanied
by
dysbiosis
gut
microbiota
(GM),
causing
decrease
in
prebiotic
levels
and
an
increase
harmful
metabolite
levels.
This
leads
to
persistent
immune
response
inflammation
intestine,
greatly
impairing
physiological
function
Short-chain
fatty
acids
(SCFAs)
are
produced
probiotic
bacteria
from
fiber-rich
diet
cannot
be
digested
directly.
SCFAs
with
significant
anti-inflammatory
functions
regulate
prevent
excessive
response,
thereby
delaying
clinical
progression
IBD.
In
this
review,
we
summarize
generation
their
potential
therapeutic
effects
on
Furthermore,
suggest
may
modulate
innate
recognition
cytokine
production
intervene
Additional
randomized
controlled
trials
prospective
cohort
studies
should
also
investigate
impact
SCFA.
Video
Abstract.
Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 294 - 294
Опубликована: Янв. 20, 2023
Gut
microbes
and
their
metabolites
are
actively
involved
in
the
development
regulation
of
host
immunity,
which
can
influence
disease
susceptibility.
Herein,
we
review
most
recent
research
advancements
gut
microbiota–immune
axis.
We
discuss
detail
how
microbiota
is
a
tipping
point
for
neonatal
immune
as
indicated
by
newly
uncovered
phenomenon,
such
maternal
imprinting,
utero
intestinal
metabolome,
weaning
reaction.
describe
shapes
both
innate
adaptive
immunity
with
emphasis
on
short-chain
fatty
acids
secondary
bile
acids.
also
comprehensively
delineate
disruption
axis
results
immune-mediated
diseases,
gastrointestinal
infections,
inflammatory
bowel
cardiometabolic
disorders
(e.g.,
cardiovascular
diabetes,
hypertension),
autoimmunity
rheumatoid
arthritis),
hypersensitivity
asthma
allergies),
psychological
anxiety),
cancer
colorectal
hepatic).
further
encompass
role
fecal
transplantation,
probiotics,
prebiotics,
dietary
polyphenols
reshaping
therapeutic
potential.
Continuing,
examine
modulates
therapies,
including
checkpoint
inhibitors,
JAK
anti-TNF
therapies.
lastly
mention
current
challenges
metagenomics,
germ-free
models,
recapitulation
to
achieve
fundamental
understanding
regulates
immunity.
Altogether,
this
proposes
improving
immunotherapy
efficacy
from
perspective
microbiome-targeted
interventions.
Antioxidants,
Год журнала:
2022,
Номер
11(9), С. 1674 - 1674
Опубликована: Авг. 27, 2022
Mulberry
has
attracted
wide
attention
due
to
its
substantial
nutritional
values.
This
work
first
studied
the
protective
effect
of
mulberry
anthocyanins
(MAS)
on
dextran
sulfate
sodium
(DSS)-induced
colitis.
The
mice
experiment
was
designed
as
four
groups
including
normal
(Control),
(DSS)-fed
mice,
and
DSS
plus
100
mg/kg·bw
MAS-fed
(LMAS-DSS)
or
200
(HMAS-DSS).
Mice
were
given
MAS
by
gavage
for
1
week,
then
added
drinking
water
7
days.
administered
a
total
17
results
showed
that
oral
reduced
disease
activity
index
(DAI),
prevented
colon
shortening,
attenuated
tissue
damage
inflammatory
response,
suppressed
colonic
oxidative
stress
restored
protein
expression
intestinal
tight
junction
(TJ)
(ZO-1,
occludin
claudin-3)
in
with
DSS-induced
In
addition,
analysis
16S
rRNA
amplicon
sequences
microbiota
dysbiosis,
reduction
Escherichia-Shigella,
an
increase
Akkermansia,
Muribaculaceae
Allobaculum.
Collectively,
alleviates
colitis
maintaining
barrier,
modulating
cytokines,
improving
microbial
community.
Nature Biomedical Engineering,
Год журнала:
2022,
Номер
7(1), С. 38 - 55
Опубликована: Дек. 22, 2022
The
microbiome
modulates
host
immunity
and
aids
the
maintenance
of
tolerance
in
gut,
where
microbial
food-derived
antigens
are
abundant.
Yet
modern
dietary
factors
excessive
use
antibiotics
have
contributed
to
rising
incidence
food
allergies,
inflammatory
bowel
disease
other
non-communicable
chronic
diseases
associated
with
depletion
beneficial
taxa,
including
butyrate-producing
Clostridia.
Here
we
show
that
intragastrically
delivered
neutral
negatively
charged
polymeric
micelles
releasing
butyrate
different
regions
intestinal
tract
restore
barrier-protective
responses
mouse
models
colitis
peanut
allergy.
Treatment
butyrate-releasing
increased
abundance
taxa
Clostridium
cluster
XIVa,
protected
mice
from
an
anaphylactic
reaction
a
challenge
reduced
severity
T-cell-transfer
model
colitis.
By
restoring
mucosal
homoeostasis,
may
function
as
antigen-agnostic
approach
for
treatment
allergic
diseases.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
151, С. 113163 - 113163
Опубликована: Май 24, 2022
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
an
aggressive
cancer.
The
characteristic
excessive
stromatogenesis
accompanying
the
growth
of
this
tumor
believed
to
contribute
chemoresistance
which,
together
with
drug
toxicity,
results
in
poor
clinical
outcome.
An
increasing
number
studies
are
showing
that
gut
microbiota
and
their
metabolites
implicated
cancer
pathogenesis,
progression
response
therapies.
In
study
we
tested
butyrate,
a
product
dietary
fibers'
bacterial
fermentation,
whose
anticancer
anti-inflammatory
functions
known.
We
provided
vitro
evidence
that,
beside
slowing
proliferation,
butyrate
enhanced
gemcitabine
effectiveness
against
two
human
pancreatic
cell
lines,
mainly
inducing
apoptosis.
addition,
observed
when
administered
PDAC
mouse
model,
alone
or
combined
treatment,
markedly
reduced
cancer-associated
stromatogenesis,
preserved
intestinal
mucosa
integrity
affected
fecal
composition
by
short
chain
fatty
acids
producing
bacteria
decreasing
some
pro-inflammatory
microorganisms.
Furthermore,
biochemical
serum
analysis
showed
ameliorate
markers
kidney
liver
damage,
whereas
metabolomics
approach
revealed
deep
modification
lipid
metabolism,
which
may
affect
therapy.
Such
support
supplementation,
addition
conventional
therapies,
can
interfere
biology
treatment
alleviate
damages
associated
itself
chemotherapy.
Nutrients,
Год журнала:
2023,
Номер
15(10), С. 2275 - 2275
Опубликована: Май 11, 2023
Background
and
objective:
Inflammatory
bowel
disease
(IBD),
including
Crohn’s
ulcerative
colitis,
is
a
chronic
inflammatory
disorder
characterized
by
aberrant
immune
responses
compromised
barrier
function
in
the
gastrointestinal
tract.
IBD
associated
with
altered
gut
microbiota
their
metabolites
colon.
Butyrate,
microbial
metabolite,
plays
crucial
role
regulating
function,
epithelial
intestinal
homeostasis.
In
this
review,
we
aim
to
present
an
overview
of
butyrate
synthesis
metabolism
mechanism
action
maintaining
homeostasis
discuss
therapeutic
implications
IBD.
Methods:
We
searched
literature
up
March
2023
through
PubMed,
Web
Science,
other
sources
using
search
terms
such
as
butyrate,
inflammation,
IBD,
disease,
colitis.
Clinical
studies
patients
preclinical
rodent
models
were
included
summary
butyrate.
Results:
Research
last
two
decades
has
shown
beneficial
effects
on
function.
Most
clinical
have
positive
effect
oral
supplements
reducing
inflammation
remission
colitis
animal
patients.
However,
enema
showed
mixed
effects.
Butyrogenic
diets,
germinated
barley
foodstuff
oat
bran,
are
found
increase
fecal
concentrations
reduce
activity
index
both
Conclusions:
The
current
suggests
that
potential
add-on
therapy
maintain
remission.
Further
needed
determine
if
administration
alone
effective
treatment
for