Metabolites,
Год журнала:
2024,
Номер
14(10), С. 539 - 539
Опубликована: Окт. 9, 2024
:
Pentosidine
is
an
advanced
glycation
end
product
that
commonly
found
in
heat-processed
foods.
has
been
involved
the
occurrence
and
development
of
some
chronic
diseases.
It
was
reported
pentosidine
exposure
can
impair
function
liver
kidneys.
Adipose
tissue,
as
active
endocrine
organ,
plays
important
role
maintaining
normal
physiological
cells.
However,
metabolic
mechanism
causes
to
induce
toxicity
adipose
tissue
remains
unclear.
Journal of Hepatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
The
liver
acts
as
a
central
metabolic
hub,
integrating
signals
from
the
gastrointestinal
tract
and
adipose
tissue
to
regulate
carbohydrate,
lipid,
amino
acid
metabolism.
Gut-derived
metabolites,
such
acetate
ethanol
non-esterified
fatty
acids
white
(WAT),
influence
hepatic
processes,
which
rely
on
mitochondrial
function
maintain
systemic
energy
balance.
Metabolic
dysregulation
obesity,
insulin
resistance,
type
2
diabetes
disrupt
these
pathways,
leading
dysfunction-associated
steatotic
disease
(MASLD)
steatohepatitis
(MASH).
This
review
explores
fluxes
within
gut-adipose
tissue-liver
axis,
focusing
pivotal
role
of
de
novo
lipogenesis
(DNL),
dietary
substrates
like
glucose
fructose,
changes
in
during
MASLD
progression.
It
highlights
contributions
resistance
impaired
dynamics
lipid
accumulation.
Further
understanding
how
interplay
between
substrate
flux
gastro-intestinal
integrates
with
intersects
structural
functional
alterations
mitochondria
will
be
important
identify
novel
therapeutic
targets
advance
treatment
MASH.
Clinical Interventions in Aging,
Год журнала:
2024,
Номер
Volume 19, С. 1407 - 1422
Опубликована: Авг. 1, 2024
With
the
increasingly
severe
situation
of
obesity
and
population
aging,
there
is
growing
concern
about
sarcopenia
(SO).
SO
refers
to
coexistence
sarcopenia,
which
imposes
a
heavier
burden
on
individuals
society
compared
or
alone.
Therefore,
comprehending
pathogenesis
implementing
effective
clinical
interventions
are
vital
for
its
prevention
treatment.
This
review
uses
comprehensive
literature
search
analysis
PubMed,
Web
Science,
CNKI
databases,
with
terms
including
"Sarcopenic
obesity",
"exercise",
"cytokines",
"inflammation",
"mitochondrial
quality
control",
"microRNA",
covering
relevant
studies
published
up
July
2024.
The
results
indicate
that
complex,
involving
mechanisms
like
age-related
changes
in
body
composition,
hormonal
alterations,
inflammation,
mitochondrial
dysfunction,
genetic
epigenetic
factors.
Regarding
exercise
SO,
aerobic
can
reduce
fat
mass,
resistance
increase
skeletal
muscle
mass
strength,
combined
achieve
both,
making
it
optimal
intervention
SO.
potential
by
may
prevent
treat
include
regulating
cytokine
secretion,
inhibiting
inflammatory
pathways,
improving
quality,
mediating
microRNA
expression.
emphasizes
effectiveness
mitigating
sarcopenic
through
multifactorial
mechanistic
insights
into
exercise's
therapeutic
effects.
Understanding
these
informs
targeted
strategies
aimed
at
alleviating
societal
individual
burdens
associated
Journal of Pharmacological Sciences,
Год журнала:
2025,
Номер
158(1), С. 27 - 41
Опубликована: Март 4, 2025
Pueraria
Mirifica
(Willd.
Ohwi)
is
a
medicine
with
anti-inflammatory
and
lipid-lowering
properties.
Puerarin
one
of
the
main
active
components
Pueraria.
The
aim
this
study
was
to
investigate
possible
mechanisms
in
treatment
non-alcoholic
fatty
liver
disease.
therapeutic
effect
drug
demonstrated
by
serum
pathology
indicators.
mechanism
action
puerarin
intestinal
microbial
changes
short-chain
acid
content
tests.
alleviating
Metabolic
dysfunction-associated
steatotic
disease
(MASLD)
regulating
flora
predicted
bioinformatics.
relationship
between
revealed
q-PCR
detection
mRNA
expression
level
metabolic
genes.
And
further
verified
clearance
experiments.
reduced
vacuolar-like
changes,
lipid
deposition,
inflammatory
cell
infiltration
livers
high-fat
diet
(HFD)
model
mice.
gut
microbiota
abundance
diversity
were
remodeled,
increased,
mucosal
barrier
repaired,
accompanied
reduction
cytokines.
regulated
hepatic
metabolism
genes
alleviate
MASLD.
These
results
suggested
that
treats
MASLD
treating
altering
bacterial
anti-inflammation.
Diabetes Obesity and Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Anti‐obesity
medications
have
reached
new
heights
in
terms
of
efficacy,
with
presently
available
pharmacological
options
almost
reaching
the
efficacy
surgical
techniques,
and
thus
these
are
starting
to
fill
treatment
void.
Because
increased
weight
loss
benefits
on
a
host
obesity
complications
being
reported,
prevention
diabetes,
reduction
liver
cardiovascular
improvements
osteoarthritis
among
prominent
features.
On
other
hand,
present
anti‐obesity
strategies
also
lead
lean
bone
mass,
while
consequences
hereof
only
beginning
present,
they
highly
likely
be
importance
target
population
that
contains
large
number
elderly
potentially
frail
individuals.
Therefore,
there
is
need
address
issue
quality,
both
context
existing
possibilities,
but
especially
myriad
novel
horizon.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 14, 2025
Background
Obesity
is
a
metabolic
disease
that
characterized
by
an
excessive
accumulation
of
adipose
tissue
(AT)
and
often
associated
with
other
pathologies.
AT
lipid
storage
organ
endocrine
functions
presents
two
main
phenotypes:
white
(WAT)
brown
(BAT).
Preadipocytes
or
mature
adipocyte
cells
can
differentiate
in
middle
phenotype
morpho/functional
characteristics
between
WAT
BAT,
known
as
brown-like
beige
(BeAT),
through
the
browning
process.
Considering
interest
stimulating
process
disorders
lack
clarity,
evenness,
reproducibility
preclinical
models,
detailed
description
differentiation
protocol
“
de
novo
”
development
has
been
described.
Furthermore,
most
described
stimuli
inducing
process,
such
PPAR-γ
agonists
(using
rosiglitazone,
RGZ)
β-adrenergic
stimulators
isoproterenol,
ISO),
were
evaluated
order
to
describe
their
involvement
identify
reference
compound
for
induction
browning.
Methods
Immortalized
murine
embryonic
fibroblasts
(3T3-L1)
differentiated
up
17
days
using
medium
(DM)
maintenance
(MM)
without
RGZ
ISO
obtain
both
phenotype.
The
was
Oil
Red
O
(ORO)
staining
assay,
citrate
synthase
activity,
mitochondrial
uncoupling
protein
1
(UCP-1)
immunodetection
expression
performed
on
different
(T0,
T3,
T10,
T17)
after
differentiation.
Results
results
indicated
induced
morphology
ORO-positive
deposits
increased
activity
enzyme
UCP-1
levels
overlapping
days.
did
not
display
significant
effect
these
experimental
conditions.
Conclusion
Overall,
this
work
describes
depth
phases
offering
reproducible
model.
efficacy
stimulation
pathway
obtaining
demonstrates
induce
elects
it
perfect
procedures
field.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8979 - 8979
Опубликована: Авг. 18, 2024
Chronic
low-grade
inflammation
(CLGI)
is
associated
with
obesity
and
one
of
its
pathogenetic
mechanisms.
Lipopolysaccharide
(LPS),
a
component
Gram-negative
bacterial
cell
walls,
the
principal
cause
CLGI.
Studies
have
found
that
capsaicin
significantly
reduces
relative
abundance
LPS-producing
bacteria.
In
present
study,
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 12, 2024
Background
Endometriosis
is
an
estrogen-dependent
gynecological
endocrine
condition
and
a
systemic
inflammatory
disease
associated
to
improper
lipid
metabolism
increased
cardiovascular
risk.
The
Cardiometabolic
Index
(CMI)
novel
indicator
representing
visceral
adipose
tissue
distribution
metabolic
dysfunction,
integrating
indicators
the
waist-to-height
ratio.
While
anomalies
in
are
often
with
(BMI)
Body
Mass
Index,
literature
consistently
shows
negative
link
between
endometriosis
female
BMI,
some
studies
have
found
that
one
of
few
reproductive
diseases
not
persistently
positively
correlated
obesity.
Given
limitations
comprehensive
index
like
CMI
crucial
for
exploring
incidence
endometriosis.
Currently,
research
on
correlation
lacking,
prompting
this
study
investigate
association.
Objective
To
association
risk
having
sample
entire
U.S.
population.
Study
design
A
cross-sectional
analysis
was
conducted
using
data
from
four
cycles
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
years
1999
2006.
included
individuals
aged
20
54
documented
history
complete
data.
Logistic
regression
analysis,
subgroup
interaction
analyses,
smooth
curve
fitting,
restricted
cubic
splines
(RCS)
were
utilized
examine
Results
higher
had
probability
developing
This
relationship
remained
significant
after
adjusting
potential
confounders
such
as
age,
ethnicity,
Poverty
Income
Ratio
(PIR),
drinking,
smoking,
education
level,
marital
status.
fully
adjusted
model
revealed
positive
(OR
=
1.21;
95%
CI,
1.04–1.40,
p
<
0.05).
Subgroup
analyses
showed
no
effect
modification
by
PIR,
hypertension,
or
menarche
age
(all
p-values
>
Conclusion
Our
chance
getting
endometriosis.Due
common
occurrence
lack
clarity
surrounding
their
cause,
more
needed
confirm
our
results
find
out
if
could
be
used
warning
sign
