Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation

Frontiers in Science, Год журнала: 2024, Номер 2

Опубликована: Апрель 4, 2024

Global warming and climate change have increased the pollen burden frequency intensity of wildfires, sand dust storms, thunderstorms, heatwaves—with concomitant increases in air pollution, heat stress, flooding. These environmental stressors alter human exposome trigger complex immune responses. In parallel, pollutants, allergens, other factors increase risks skin mucosal barrier disruption microbial dysbiosis, while a loss biodiversity reduced exposure to diversity impairs tolerogenic development. The resulting dysregulation is contributing an immune-mediated diseases such as asthma allergic diseases, autoimmune cancer. It now abundantly clear that multisectoral, multidisciplinary, transborder efforts based on Planetary Health One approaches (which consider dependence health environment natural ecosystems) are urgently needed adapt mitigate effects change. Key actions include reducing emissions improving quality (through fossil fuel use), providing safe housing (e.g., weatherization), diets (i.e., diversity) agricultural practices, increasing green spaces. There also pressing need for collaborative, multidisciplinary research better understand pathophysiology context New data science techniques, biomarkers, economic models should be used measure impact disease, inform mitigation adaptation efforts, evaluate their effectiveness. Justice, equity, diversity, inclusion (JEDI) considerations integral these address disparities

Язык: Английский

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The influence of urban exposures and residence on childhood asthma

Pediatric Allergy and Immunology, Год журнала: 2022, Номер 33(5)

Опубликована: Май 1, 2022

Children with asthma who live in urban neighborhoods experience a disproportionately high burden, increased incident and symptoms, exacerbations, acute visits hospitalizations for asthma. There are multiple exposures that contribute to pediatric morbidity, including exposure pest allergens, mold, endotoxin, indoor outdoor air pollution. living also inequities social determinants of health, such as poverty, substandard housing quality, rates obesity, chronic stress. These disparities then turn can increase the risk compound morbidity poor repair is factor infestation mold poverty Environmental interventions reduce in-home allergen concentrations have yielded inconsistent results. Population-level smoking bans public places legislation decrease traffic-related pollution been successful at reducing improving lung function growth. Given interface synergy between it likely population community-level changes will be needed excess burden children neighborhoods.

Язык: Английский

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Association of a Housing Mobility Program With Childhood Asthma Symptoms and Exacerbations

JAMA, Год журнала: 2023, Номер 329(19), С. 1671 - 1671

Опубликована: Май 16, 2023

Importance Structural racism has been implicated in the disproportionally high asthma morbidity experienced by children living disadvantaged, urban neighborhoods. Current approaches designed to reduce triggers have modest impact. Objective To examine whether participation a housing mobility program that provided vouchers and assistance moving low-poverty neighborhoods was associated with reduced among explore potential mediating factors. Design, Setting, Participants Cohort study of 123 aged 5 17 years persistent whose families participated Baltimore Regional Housing Partnership from 2016 2020. Children were matched 115 enrolled Urban Environment Childhood Asthma (URECA) birth cohort using propensity scores. Exposure Moving neighborhood. Main Outcomes Caregiver-reported exacerbations symptoms. Results Among program, median age 8.4 years, 58 (47.2%) female, 120 (97.6%) Black. Prior moving, 89 110 (81%) lived high-poverty census tract (>20% below poverty line); after only 1 106 after-move data (0.9%) tract. this cohort, 15.1% (SD, 35.8) had at least exacerbation per 3-month period prior vs 8.5% 28.0) an adjusted difference −6.8 percentage points (95% CI, −11.9% −1.7%; P = .009). Maximum symptom days past 2 weeks 5.1 5.0) before 2.7 3.8) −2.37 −3.14 −1.59; < .001). remained significant score–matched analyses URECA data. Measures stress, including social cohesion, neighborhood safety, all improved estimated mediate between 29% 35% association exacerbations. Conclusions Relevance helped them move into improvements This adds limited evidence suggesting programs counter discrimination can childhood morbidity.

Язык: Английский

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Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO

Pediatric Allergy and Immunology, Год журнала: 2024, Номер 35(4)

Опубликована: Апрель 1, 2024

Abstract Monitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural history review. Numerous factors that may affect disease activity patient well‐being need to be monitored: response adherence treatment, control, progression, comorbidities, quality life, medication side‐effects, allergen irritant exposures, diet more. However, the prioritization such selection relevant assessment tools an unmet need. Furthermore, rapidly developing technologies promise new opportunities closer, or even “real‐time,” between visits. Following approach included needs assessment, evidence appraisal, Delphi consensus, PeARL Think Tank, collaboration with international professional organizations, has developed set 24 recommendations on pediatric monitoring, support healthcare professionals decision‐making care pathway design. image

Язык: Английский

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The impact of indoor air pollution on children’s health and well-being: the experts’ consensus

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Год журнала: 2024, Номер 50(1)

Опубликована: Апрель 14, 2024

Abstract Background Pollution of the indoor environment represents a concern for human health, mainly in case prolonged exposure such as women, children, elderly, and chronically ill, who spend most their time closed environments. Main body The aim study is to organize group experts order evaluate evidence discuss main risk factors concerning air impact on health well challenging regarding preventive strategies reduce pollution. highlighted air, including poor ventilation, climatic conditions, chemical substances, socio-economic status. They discussed terms mortality morbidity, Conclusion identified that can be reinforced pollution prevent negative consequences at national local levels.

Язык: Английский

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Mechanisms and Consequences of Variable TRPA1 Expression by Airway Epithelial Cells: Effects of TRPV1 Genotype and Environmental Agonists on Cellular Responses to Pollutants in Vitro and Asthma

Environmental Health Perspectives, Год журнала: 2023, Номер 131(2)

Опубликована: Фев. 1, 2023

Background: Transient receptor potential ankyrin-1 [transient cation channel subfamily A member 1 (TRPA1)] and vanilloid-1 V (TRPV1)] detect inhaled irritants, including air pollutants have roles in the development exacerbation of asthma. Objectives: This study tested hypothesis that increased expression TRPA1, stemming from loss-of-function TRPV1 (I585V; rs8065080) polymorphic variant by airway epithelial cells may explain prior observations worse asthma symptom control among children with I585I/V genotype, virtue sensitizing to particulate materials other TRPA1 agonists. Methods: TRP agonists, antagonists, small interfering RNA (siRNA), a nuclear factor kappa light chain enhancer activated B (NF-κB) pathway inhibitor, kinase activators inhibitors were used modulate function. Treatment genotyped analysis data assess consequences genotype variable on cellular responses vitro as function voluntarily reported tobacco smoke exposure. Results: relationship between higher lower was revealed. Findings this pointed mechanism whereby NF-κB promoted expression, whereas NF-κB–regulated nucleotide-binding oligomerization domain, leucine rich repeat pyrin domain containing 2 (NLRP2) limited expression. Roles for protein C p38 mitogen also demonstrated. Finally, associated primary amplified selected pollution particles vitro. However, not exposed smoke, variants were. Discussion: provides insights how regulate genetics can affect polymorphisms differentially control. https://doi.org/10.1289/EHP11076

Язык: Английский

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The Effect of Climate Change on Allergen and Irritant Exposure

The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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Environmental exposures related to gut microbiota among children with asthma: a pioneer study in Taiwan

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117793 - 117793

Опубликована: Янв. 31, 2025

Gut microbiota plays a crucial role in human health and can be influenced by environmental factors. While past studies have examined the impact of environment on gut microbiota, vulnerable populations often been overlooked. This study aimed to investigate association between exposures, air pollution greenspace, asthmatic children. Data were collected during recovery period for 41 eligible Air was estimated using an ensemble learning model that combined regression machine-learning algorithms, while greenspace quantified normalized difference vegetation index (NDVI) green land-cover data. The lag effects exposures assessed within defined buffer zones surrounding each child's residence. A generalized additive applied examine associations. Results revealed marginally significant negative 1-day exposure NO₂ indices, such as observed bacteria (Coef.: -1.130; 95 %CI -2.287, 0.027) bacterial richness -2.420; -4.987, 0.146). 8-day lagged average PM2.5 O₃ also showed impacts diversity. In contrast, 1-month positively associated with indices. linked specific abundances, Streptococcus. underscores need further research how factors may influence immunity children altering microbiota.

Язык: Английский

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Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 9, 2025

Lung disease is the most overrepresented cause of death in rheumatoid arthritis (RA). Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung with a combination airborne exposures collagen-induced (CIA), model that recapitulates features RA-associated interstitial (RA-ILD). As patients RA-ILD demonstrate unique circulating monocyte subpopulations, this study aims to characterize infiltrating monocytes/macrophages mouse determine whether reducing these cells mitigates development disease. Autoimmune-prone DBA/1J mice received intranasal inhalation lipopolysaccharide (LPS) daily for up 5 weeks CIA induction. Experimental groups included Sham (saline injection/saline inhalation), (CIA/saline), LPS (saline/LPS), CIA+LPS (CIA/LPS). was assessed by longitudinal imaging, function measurements, bronchoalveolar lavage fluid, tissues, histopathology. Cell subpopulations were analyzed single cell RNA-sequencing flow cytometry. Intravenous clodronate liposome administration employed reduce monocytes. Longitudinal imaging increased volume tissue density mice. assessment showed reduced compliance airway resistance dual exposure. Unsupervised clustering revealed 16 discrete clusters among experimental robust overlapping characteristics both CIA. By cytometry, exposure induced activated CD11c+CD206+CD11b+MHC Class IIhiCD80+ alveolar macrophages, CD11cmidCD206-CD11b+Ly6Chi(and Ly6Clo)MHC IIhiCD80+CD86+ CD11c-CD11b+Ly6ChiMHC monocytic-like cells. MHC IIhi-expressing across monocyte/macrophage treated more aligned than alone. CIA+LPS-induced CD11c+CD11b+ CD11cmidCD11b+ neutrophils, lymphocytes, inflammatory/pro-fibrotic mediators, expression vimentin citrullinated malondialdehyde acetaldehyde (MAA)-modified proteins/lung autoantigens. The interaction inhalation-induced inflammation autoimmune results associated uniquely inflammatory macrophages. Moreover, depletion monocytes attenuated Whereas macrophage immunophenotype endotoxin exposure, co-exposure modeling renders potentially inform pathogenesis treatment RA-ILD.

Язык: Английский

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Indoor Environmental Exposures and Their Relationship to Allergic Diseases

The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2023, Номер 11(10), С. 2963 - 2970

Опубликована: Авг. 29, 2023

Язык: Английский

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