Molecules,
Год журнала:
2023,
Номер
28(4), С. 1552 - 1552
Опубликована: Фев. 6, 2023
Resistance
to
conventional
treatments
renders
urgent
the
discovery
of
new
therapeutic
molecules.
Plant
specialized
metabolites
such
as
phenolamides,
a
subclass
phenolic
compounds,
whose
accumulation
in
tomato
plants
is
mediated
by
biotic
and
abiotic
environment,
constitute
source
natural
molecules
endowed
with
potential
antioxidant,
antimicrobial
well
anti-inflammatory
properties.
The
aim
our
study
was
investigate
whether
three
major
phenolamides
found
Tuta
absoluta-infested
leaves
exhibit
antimicrobial,
cytotoxic
and/or
One
them,
N1,N5,N14-tris(dihydrocaffeoyl)spermine,
specifically
synthesized
for
this
study.
showed
low
moderate
antibacterial
activities
but
were
able
counteract
LPS
pro-inflammatory
effect
on
THP-1
cells
differentiated
into
macrophages.
Extracts
made
from
healthy
not
T.
leaf
extracts
also
reduce
inflammation
using
same
cellular
approach.
Taken
together,
these
results
show
that
could
be
interesting
alternatives
drugs.
Global
warming
and
climate
change
have
increased
the
pollen
burden
frequency
intensity
of
wildfires,
sand
dust
storms,
thunderstorms,
heatwaves—with
concomitant
increases
in
air
pollution,
heat
stress,
flooding.
These
environmental
stressors
alter
human
exposome
trigger
complex
immune
responses.
In
parallel,
pollutants,
allergens,
other
factors
increase
risks
skin
mucosal
barrier
disruption
microbial
dysbiosis,
while
a
loss
biodiversity
reduced
exposure
to
diversity
impairs
tolerogenic
development.
The
resulting
dysregulation
is
contributing
an
immune-mediated
diseases
such
as
asthma
allergic
diseases,
autoimmune
cancer.
It
now
abundantly
clear
that
multisectoral,
multidisciplinary,
transborder
efforts
based
on
Planetary
Health
One
approaches
(which
consider
dependence
health
environment
natural
ecosystems)
are
urgently
needed
adapt
mitigate
effects
change.
Key
actions
include
reducing
emissions
improving
quality
(through
fossil
fuel
use),
providing
safe
housing
(e.g.,
weatherization),
diets
(i.e.,
diversity)
agricultural
practices,
increasing
green
spaces.
There
also
pressing
need
for
collaborative,
multidisciplinary
research
better
understand
pathophysiology
context
New
data
science
techniques,
biomarkers,
economic
models
should
be
used
measure
impact
disease,
inform
mitigation
adaptation
efforts,
evaluate
their
effectiveness.
Justice,
equity,
diversity,
inclusion
(JEDI)
considerations
integral
these
address
disparities
Pediatric Allergy and Immunology,
Год журнала:
2022,
Номер
33(5)
Опубликована: Май 1, 2022
Children
with
asthma
who
live
in
urban
neighborhoods
experience
a
disproportionately
high
burden,
increased
incident
and
symptoms,
exacerbations,
acute
visits
hospitalizations
for
asthma.
There
are
multiple
exposures
that
contribute
to
pediatric
morbidity,
including
exposure
pest
allergens,
mold,
endotoxin,
indoor
outdoor
air
pollution.
living
also
inequities
social
determinants
of
health,
such
as
poverty,
substandard
housing
quality,
rates
obesity,
chronic
stress.
These
disparities
then
turn
can
increase
the
risk
compound
morbidity
poor
repair
is
factor
infestation
mold
poverty
Environmental
interventions
reduce
in-home
allergen
concentrations
have
yielded
inconsistent
results.
Population-level
smoking
bans
public
places
legislation
decrease
traffic-related
pollution
been
successful
at
reducing
improving
lung
function
growth.
Given
interface
synergy
between
it
likely
population
community-level
changes
will
be
needed
excess
burden
children
neighborhoods.
JAMA,
Год журнала:
2023,
Номер
329(19), С. 1671 - 1671
Опубликована: Май 16, 2023
Importance
Structural
racism
has
been
implicated
in
the
disproportionally
high
asthma
morbidity
experienced
by
children
living
disadvantaged,
urban
neighborhoods.
Current
approaches
designed
to
reduce
triggers
have
modest
impact.
Objective
To
examine
whether
participation
a
housing
mobility
program
that
provided
vouchers
and
assistance
moving
low-poverty
neighborhoods
was
associated
with
reduced
among
explore
potential
mediating
factors.
Design,
Setting,
Participants
Cohort
study
of
123
aged
5
17
years
persistent
whose
families
participated
Baltimore
Regional
Housing
Partnership
from
2016
2020.
Children
were
matched
115
enrolled
Urban
Environment
Childhood
Asthma
(URECA)
birth
cohort
using
propensity
scores.
Exposure
Moving
neighborhood.
Main
Outcomes
Caregiver-reported
exacerbations
symptoms.
Results
Among
program,
median
age
8.4
years,
58
(47.2%)
female,
120
(97.6%)
Black.
Prior
moving,
89
110
(81%)
lived
high-poverty
census
tract
(>20%
below
poverty
line);
after
only
1
106
after-move
data
(0.9%)
tract.
this
cohort,
15.1%
(SD,
35.8)
had
at
least
exacerbation
per
3-month
period
prior
vs
8.5%
28.0)
an
adjusted
difference
−6.8
percentage
points
(95%
CI,
−11.9%
−1.7%;
P
=
.009).
Maximum
symptom
days
past
2
weeks
5.1
5.0)
before
2.7
3.8)
−2.37
−3.14
−1.59;
<
.001).
remained
significant
score–matched
analyses
URECA
data.
Measures
stress,
including
social
cohesion,
neighborhood
safety,
all
improved
estimated
mediate
between
29%
35%
association
exacerbations.
Conclusions
Relevance
helped
them
move
into
improvements
This
adds
limited
evidence
suggesting
programs
counter
discrimination
can
childhood
morbidity.
Pediatric Allergy and Immunology,
Год журнала:
2024,
Номер
35(4)
Опубликована: Апрель 1, 2024
Abstract
Monitoring
is
a
major
component
of
asthma
management
in
children.
Regular
monitoring
allows
for
diagnosis
confirmation,
treatment
optimization,
and
natural
history
review.
Numerous
factors
that
may
affect
disease
activity
patient
well‐being
need
to
be
monitored:
response
adherence
treatment,
control,
progression,
comorbidities,
quality
life,
medication
side‐effects,
allergen
irritant
exposures,
diet
more.
However,
the
prioritization
such
selection
relevant
assessment
tools
an
unmet
need.
Furthermore,
rapidly
developing
technologies
promise
new
opportunities
closer,
or
even
“real‐time,”
between
visits.
Following
approach
included
needs
assessment,
evidence
appraisal,
Delphi
consensus,
PeARL
Think
Tank,
collaboration
with
international
professional
organizations,
has
developed
set
24
recommendations
on
pediatric
monitoring,
support
healthcare
professionals
decision‐making
care
pathway
design.
image
The Italian Journal of Pediatrics/Italian journal of pediatrics,
Год журнала:
2024,
Номер
50(1)
Опубликована: Апрель 14, 2024
Abstract
Background
Pollution
of
the
indoor
environment
represents
a
concern
for
human
health,
mainly
in
case
prolonged
exposure
such
as
women,
children,
elderly,
and
chronically
ill,
who
spend
most
their
time
closed
environments.
Main
body
The
aim
study
is
to
organize
group
experts
order
evaluate
evidence
discuss
main
risk
factors
concerning
air
impact
on
health
well
challenging
regarding
preventive
strategies
reduce
pollution.
highlighted
air,
including
poor
ventilation,
climatic
conditions,
chemical
substances,
socio-economic
status.
They
discussed
terms
mortality
morbidity,
Conclusion
identified
that
can
be
reinforced
pollution
prevent
negative
consequences
at
national
local
levels.
Environmental Health Perspectives,
Год журнала:
2023,
Номер
131(2)
Опубликована: Фев. 1, 2023
Background:
Transient
receptor
potential
ankyrin-1
[transient
cation
channel
subfamily
A
member
1
(TRPA1)]
and
vanilloid-1
V
(TRPV1)]
detect
inhaled
irritants,
including
air
pollutants
have
roles
in
the
development
exacerbation
of
asthma.
Objectives:
This
study
tested
hypothesis
that
increased
expression
TRPA1,
stemming
from
loss-of-function
TRPV1
(I585V;
rs8065080)
polymorphic
variant
by
airway
epithelial
cells
may
explain
prior
observations
worse
asthma
symptom
control
among
children
with
I585I/V
genotype,
virtue
sensitizing
to
particulate
materials
other
TRPA1
agonists.
Methods:
TRP
agonists,
antagonists,
small
interfering
RNA
(siRNA),
a
nuclear
factor
kappa
light
chain
enhancer
activated
B
(NF-κB)
pathway
inhibitor,
kinase
activators
inhibitors
were
used
modulate
function.
Treatment
genotyped
analysis
data
assess
consequences
genotype
variable
on
cellular
responses
vitro
as
function
voluntarily
reported
tobacco
smoke
exposure.
Results:
relationship
between
higher
lower
was
revealed.
Findings
this
pointed
mechanism
whereby
NF-κB
promoted
expression,
whereas
NF-κB–regulated
nucleotide-binding
oligomerization
domain,
leucine
rich
repeat
pyrin
domain
containing
2
(NLRP2)
limited
expression.
Roles
for
protein
C
p38
mitogen
also
demonstrated.
Finally,
associated
primary
amplified
selected
pollution
particles
vitro.
However,
not
exposed
smoke,
variants
were.
Discussion:
provides
insights
how
regulate
genetics
can
affect
polymorphisms
differentially
control.
https://doi.org/10.1289/EHP11076
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
291, С. 117793 - 117793
Опубликована: Янв. 31, 2025
Gut
microbiota
plays
a
crucial
role
in
human
health
and
can
be
influenced
by
environmental
factors.
While
past
studies
have
examined
the
impact
of
environment
on
gut
microbiota,
vulnerable
populations
often
been
overlooked.
This
study
aimed
to
investigate
association
between
exposures,
air
pollution
greenspace,
asthmatic
children.
Data
were
collected
during
recovery
period
for
41
eligible
Air
was
estimated
using
an
ensemble
learning
model
that
combined
regression
machine-learning
algorithms,
while
greenspace
quantified
normalized
difference
vegetation
index
(NDVI)
green
land-cover
data.
The
lag
effects
exposures
assessed
within
defined
buffer
zones
surrounding
each
child's
residence.
A
generalized
additive
applied
examine
associations.
Results
revealed
marginally
significant
negative
1-day
exposure
NO₂
indices,
such
as
observed
bacteria
(Coef.:
-1.130;
95
%CI
-2.287,
0.027)
bacterial
richness
-2.420;
-4.987,
0.146).
8-day
lagged
average
PM2.5
O₃
also
showed
impacts
diversity.
In
contrast,
1-month
positively
associated
with
indices.
linked
specific
abundances,
Streptococcus.
underscores
need
further
research
how
factors
may
influence
immunity
children
altering
microbiota.