Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Июль 13, 2023
Porphyromonas
gingivalis
(P.
gingivalis)
is
a
Gram-negative
oral
anaerobic
bacterium
that
plays
key
role
in
the
pathogenesis
of
periodontitis.
P.
expresses
variety
virulence
factors
disrupt
innate
and
adaptive
immunity,
allowing
to
survive
multiply
host
destroy
periodontal
tissue.
In
addition
disease,
P.gingivalis
also
associated
with
systemic
diseases,
which
insulin
resistance
an
important
pathological
basis.
causes
inflammatory
response,
disrupts
signaling
pathways,
induces
pancreatic
β-cell
hypofunction
reduced
numbers,
decreased
sensitivity
leading
(IR).
this
paper,
we
systematically
review
studies
on
mechanism
induced
by
,
discuss
association
between
diseases
based
resistance,
finally
propose
relevant
therapeutic
approaches.
Overall,
through
systematic
mechanisms
related
caused
hope
provide
new
insights
for
future
basic
research
clinical
interventions
diseases.
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 837 - 851
Опубликована: Фев. 1, 2024
Abstract:
Substantial
evidence
has
recently
been
gathered
to
substantiate
the
epidemiological
correlation
between
this
oral
inflammatory
ailment
and
several
systemic
health
disorders,
such
as
cardiovascular
diseases
(CVDs).
It
is
worth
noting
that
certain
shared
factors
exist
among
individuals
with
periodontal
disease
(PD)
CVDs,
like
obesity
or
overweight,
minimal
physical
activities,
smoking
habits,
male
gender,
low
socioeconomic
position,
advanced
age,
limited
educational
attainment.
Moreover,
recent
research
suggests
a
distinct
separate
relationship
PD
CVDs.
This
literature
review
discusses
association
CVDs
their
underlying
mechanisms
connections.
Current
strongly
confirms
risk
PD.
The
involve
inflammation,
epigenetics,
epithelial
dysfunction,
microbiome
dysbiosis,
efficacy
of
periodontitis
treatment.
Future
investigations
are
required
comprehend
these
complex
interactions
develop
targeted
interventions
for
improvement
reduction
in
risk.
Keywords:
disease,
periodontitis,
gingivitis,
health,
markers,
inflammation
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Авг. 16, 2022
Periodontitis
is
highly
prevalent
worldwide.
It
characterized
by
periodontal
attachment
and
alveolar
bone
destruction,
which
not
only
leads
to
tooth
loss
but
also
results
in
the
exacerbation
of
systematic
diseases.
As
such,
periodontitis
has
a
significant
negative
impact
on
daily
lives
patients.
Detailed
exploration
molecular
mechanisms
underlying
physiopathology
may
contribute
development
new
therapeutic
strategies
for
associated
Pyroptosis,
as
one
inflammatory
programmed
cell
death
pathways,
implicated
pathogenesis
periodontitis.
Progress
field
pyroptosis
greatly
enhanced
our
understanding
its
role
This
review
first
summarizes
activation
pathological
progression
Then,
crosstalk
between
with
apoptosis,
necroptosis,
NETosis
discussed.
Moreover,
pyroptosis,
novel
link
that
connects
systemic
disease,
reviewed.
Finally,
current
challenges
potential
target
are
highlighted.
Microorganisms,
Год журнала:
2024,
Номер
12(8), С. 1732 - 1732
Опубликована: Авг. 22, 2024
Stroke
represents
a
significant
global
health
burden,
with
substantial
impact
on
mortality,
morbidity,
and
long-term
disability.
The
examination
of
stroke
biomarkers,
particularly
the
oral
microbiome,
offers
promising
avenue
for
advancing
our
understanding
factors
that
contribute
to
risk
developing
strategies
mitigate
risk.
This
review
highlights
correlations
between
diseases,
such
as
periodontitis
caries,
onset
stroke.
Periodontal
pathogens
within
microbiome
have
been
identified
contributing
factor
in
exacerbation
stroke,
including
obesity,
dyslipidemia,
atherosclerosis,
hypertension,
endothelial
dysfunction.
alteration
may
these
conditions,
emphasizing
vital
role
prevention
cardiovascular
disease.
integration
dental
medical
practices
enhancing
efforts
improving
patient
outcomes.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Июль 13, 2023
Porphyromonas
gingivalis
(P.
gingivalis)
is
a
Gram-negative
oral
anaerobic
bacterium
that
plays
key
role
in
the
pathogenesis
of
periodontitis.
P.
expresses
variety
virulence
factors
disrupt
innate
and
adaptive
immunity,
allowing
to
survive
multiply
host
destroy
periodontal
tissue.
In
addition
disease,
P.gingivalis
also
associated
with
systemic
diseases,
which
insulin
resistance
an
important
pathological
basis.
causes
inflammatory
response,
disrupts
signaling
pathways,
induces
pancreatic
β-cell
hypofunction
reduced
numbers,
decreased
sensitivity
leading
(IR).
this
paper,
we
systematically
review
studies
on
mechanism
induced
by
,
discuss
association
between
diseases
based
resistance,
finally
propose
relevant
therapeutic
approaches.
Overall,
through
systematic
mechanisms
related
caused
hope
provide
new
insights
for
future
basic
research
clinical
interventions
diseases.
