Graefe s Archive for Clinical and Experimental Ophthalmology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Graves'
disease
(GD)
and
orbitopathy
(GO)
are
multifactorial
disorders
with
links
to
the
gut
microbiome
autoimmunity.
It
is
observed
that
patients
GD
exhibit
altered
diversity.
However,
little
known
about
role
of
oral
microbiota
in
GO.
This
study
aims
investigate
impact
health
sanitation
on
clinical
course
GO
disqualified
from
glucocorticoid
treatment
due
infections.
We
reviewed
188
admissions
127
GO,
hospitalized
a
tertiary
university
hospital.
Clinical,
biochemical,
imaging,
ophthalmological,
assessment
data
each
admission
were
analyzed.
Patients
excluded
glucocorticoids
(GCs)
therapy
foci
infection
had
activity
score
(CAS)
reassessed
after
three
months,
they
divided
into
two
groups:
without
improvement.
Finishing
dental
meantime
was
only
factor
significantly
correlated
improvement
these
(p
=
0.041).
The
secondary
finding
anti-thyroid
peroxidase
antibodies
titer
higher
group
considered
as
contraindication
for
GCs
(medians
28.50
vs
128.00;
p
0.026),
those
more
likely
smoke
than
issues
0.024).
results
our
suggest
monitoring
treating
diseases
may
be
pertinent
might
serve
supportive
strategy
managing
condition.
What
known:
new:
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Aug. 16, 2022
Periodontitis
is
highly
prevalent
worldwide.
It
characterized
by
periodontal
attachment
and
alveolar
bone
destruction,
which
not
only
leads
to
tooth
loss
but
also
results
in
the
exacerbation
of
systematic
diseases.
As
such,
periodontitis
has
a
significant
negative
impact
on
daily
lives
patients.
Detailed
exploration
molecular
mechanisms
underlying
physiopathology
may
contribute
development
new
therapeutic
strategies
for
associated
Pyroptosis,
as
one
inflammatory
programmed
cell
death
pathways,
implicated
pathogenesis
periodontitis.
Progress
field
pyroptosis
greatly
enhanced
our
understanding
its
role
This
review
first
summarizes
activation
pathological
progression
Then,
crosstalk
between
with
apoptosis,
necroptosis,
NETosis
discussed.
Moreover,
pyroptosis,
novel
link
that
connects
systemic
disease,
reviewed.
Finally,
current
challenges
potential
target
are
highlighted.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: July 13, 2023
Porphyromonas
gingivalis
(P.
gingivalis)
is
a
Gram-negative
oral
anaerobic
bacterium
that
plays
key
role
in
the
pathogenesis
of
periodontitis.
P.
expresses
variety
virulence
factors
disrupt
innate
and
adaptive
immunity,
allowing
to
survive
multiply
host
destroy
periodontal
tissue.
In
addition
disease,
P.gingivalis
also
associated
with
systemic
diseases,
which
insulin
resistance
an
important
pathological
basis.
causes
inflammatory
response,
disrupts
signaling
pathways,
induces
pancreatic
β-cell
hypofunction
reduced
numbers,
decreased
sensitivity
leading
(IR).
this
paper,
we
systematically
review
studies
on
mechanism
induced
by
,
discuss
association
between
diseases
based
resistance,
finally
propose
relevant
therapeutic
approaches.
Overall,
through
systematic
mechanisms
related
caused
hope
provide
new
insights
for
future
basic
research
clinical
interventions
diseases.
International Journal of Dental Hygiene,
Journal Year:
2024,
Volume and Issue:
22(2), P. 401 - 413
Published: Feb. 23, 2024
Abstract
Background
Type
2
diabetes
mellitus
(T2DM)
has
been
considered
by
many
studies
to
have
a
bidirectional
relationship
with
periodontitis.
This
systematic
review
and
network
meta‐analysis
aimed
investigate
the
impact
of
different
states
T2DM
when
stratified
baseline
HbA1c
on
clinical
outcomes
non‐surgical
periodontal
treatment
(NSPT).
Methods
study
followed
Preferred
Reporting
Items
for
Meta‐Analyses
(PRISMA)
guidelines
involved
an
electronic
literature
search
(from
inception
2nd
January
2023).
The
included
at
least
two
groups
patients:
chronic
periodontitis
only
(No‐DM)
or
well‐controlled/poorly
controlled
type
(WC/PC‐T2DM).
Clinical
probing
depth
(PD)
reduction,
bleeding
attachment
level
(CAL)
gain.
Direct
indirect
comparisons
between
were
assessed
meta‐analysis,
thus
allowing
us
establish
ranking.
Results
Ten
prospective
cohort
(11
data
sets)
qualitative
analysis
meta‐analysis.
in
this
had
high
consistency;
addition,
funnel
plot
Egger's
test
showed
that
articles
low
publication
bias.
Network
effect
NSPT
No‐DM
group
was
significantly
better
than
WC‐T2DM
[weighted
mean
difference
(WMD)
=
0.09,
95%
confidence
interval
(CI)
(0.01,
0.18)]
PC‐T2DM
[WMD
CI
terms
CAL
gain
0.15,
(0.02,
0.28)]
PD
reduction.
According
surface
under
cumulative
ranking
value,
highest
probability
achieving
best
outcome
following
NSPT.
Conclusions
Collectively,
our
analyses
show
exerts
significant
effects
Graefe s Archive for Clinical and Experimental Ophthalmology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Graves'
disease
(GD)
and
orbitopathy
(GO)
are
multifactorial
disorders
with
links
to
the
gut
microbiome
autoimmunity.
It
is
observed
that
patients
GD
exhibit
altered
diversity.
However,
little
known
about
role
of
oral
microbiota
in
GO.
This
study
aims
investigate
impact
health
sanitation
on
clinical
course
GO
disqualified
from
glucocorticoid
treatment
due
infections.
We
reviewed
188
admissions
127
GO,
hospitalized
a
tertiary
university
hospital.
Clinical,
biochemical,
imaging,
ophthalmological,
assessment
data
each
admission
were
analyzed.
Patients
excluded
glucocorticoids
(GCs)
therapy
foci
infection
had
activity
score
(CAS)
reassessed
after
three
months,
they
divided
into
two
groups:
without
improvement.
Finishing
dental
meantime
was
only
factor
significantly
correlated
improvement
these
(p
=
0.041).
The
secondary
finding
anti-thyroid
peroxidase
antibodies
titer
higher
group
considered
as
contraindication
for
GCs
(medians
28.50
vs
128.00;
p
0.026),
those
more
likely
smoke
than
issues
0.024).
results
our
suggest
monitoring
treating
diseases
may
be
pertinent
might
serve
supportive
strategy
managing
condition.
What
known:
new:
