Periodontal disease: A systemic condition
Periodontology 2000,
Год журнала:
2024,
Номер
96(1), С. 7 - 19
Опубликована: Окт. 1, 2024
Abstract
For
decades,
periodontitis
has
been
considered
to
be
a
local
inflammatory
disease
of
the
periodontal
tissues
in
oral
cavity.
Initially,
associations
with
multitude
noncommunicable
diseases
were
each
studied
separately,
and
relationships
shown.
The
morbidities,
such
as
cardiovascular
diseases,
rheumatoid
arthritis,
diabetes
mellitus,
respiratory
have
demonstrated.
As
most
studies
cross‐sectional
nature,
questions
about
causality
cannot
univocally
answered.
And
an
independent
risk
factor
for
one
systemic
disease,
becomes
even
more
difficult
assess
since
recently
also
associated
multimorbidity.
Periodontitis
many
share
environmental,
lifestyle
genetic
factors,
immunopathology.
Moreover,
suffering
from
common
may
increase
susceptibility
another
chronic
disease;
effects
condition
various
factors
disease.
overarching
effect
any
is
it
causing
pro‐inflammatory
state
individual;
this
shown
periodontitis.
prothrombotic
elevated
immunological
activity
such,
when
we
consider
can
affect
progression
other
importantly,
vice
versa.
this,
not
surprising
that
variety
diseases.
medical
definition
includes
different
organs
systems.
Thus,
aim
opinion
paper
propose
should
its
own
right
affects
individual's
wellbeing.
dental
profession
researchers
alike,
adapt
paradigm
shift,
advancing
out
isolated
anatomical
location
into
total
being
some
conditions
comorbid
and,
versa,
comorbidities
initiation
Язык: Английский
Association between the red blood cell distribution width-to-albumin ratio and risk of colorectal and gastric cancers: a cross-sectional study using NHANES 2005–2018
BMC Gastroenterology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 29, 2025
The
red
blood
cell
distribution
width-to-albumin
ratio
(RAR)
is
a
novel
biomarker
that
concurrently
reflects
nutritional
status
and
inflammation.
Unlike
traditional
cancer
risk
markers
focus
on
either
inflammation
or
nutrition
independently,
RAR
provides
more
integrated
assessment
of
these
interrelated
processes,
making
it
promising
tool
for
prediction.
This
study
aims
to
investigate
the
relationship
between
digestive
tract
tumors
(DTT),
with
particular
emphasis
colorectal
(CC)
gastric
(GC).
explored
DTT
using
data
from
32,953
participants
in
2005-2018
National
Health
Nutrition
Examination
Survey
(NHANES).
Although
weighted
multivariate
logistic
regression
models
were
used
adjust
potential
confounders,
residual
confounding
selection
bias
may
still
affect
accuracy
generalizability
findings,
potentially
influencing
causal
inferences.
Additionally,
subgroup
analyses,
interaction
tests,
restricted
cubic
splines
performed
further
examine
associations.
A
two-sample
Mendelian
randomization
analysis
was
also
conducted
DTT.
Among
participants,
234
diagnosed
DTT,
including
215
cases
CC
19
GC.
Higher
levels
significantly
associated
an
increased
(OR
=
1.48,
95%
CI
1.04-2.11,
P
<
0.027),
but
not
GC
1.33,
0.45-3.94,
0.60).
non-linear
association
observed.
indicated
albumin
negatively
0.84,
0.73-0.97),
while
erythrocyte
width
(RDW)
showed
no
significant
association.
reveals
risk,
indicating
serve
as
valuable
stratification.
For
individuals
abnormal
values,
integration
supplementary
screening
tools-such
fecal
occult
testing,
colonoscopy,
additional
biomarkers-could
enhance
early
detection
rates
CC.
strategy
would
allow
healthcare
providers
effectively
identify
high-risk
tailor
personalized
prevention
strategies.
Язык: Английский
Bidirectional Relationship Between Periodontal Disease and Thyroid Diseases
Current Oral Health Reports,
Год журнала:
2025,
Номер
12(1), С. 1 - 8
Опубликована: Янв. 2, 2025
Язык: Английский
Assessment of periodontal indices in Iraqi chronic myeloid leukemia patients
Review of Clinical Pharmacology and Pharmacokinetics - International Edition,
Год журнала:
2025,
Номер
39(1), С. 1 - 9
Опубликована: Фев. 11, 2025
Background:
Periodontal
diseases
are
common
in
patients
with
blood
maladies,
including
chronic
myeloid
leukemia
(CML).
Yet,
its
effect
on
the
periodontium
is
not
well
comprehended.
Aim:
This
study
assessed
periodontal
health
Iraqi
CML
using
two
key
indices,
gingival
index
(GI)
and
loss
of
attachment
(LOA),
examined
their
cor¬relation
white
cell
(WBC)
counts.
Methodology:
A
cross-sectional
was
conducted
100
partici¬pants,
50
age-and
gender-matched
healthy
controls.
GI
LOA
were
measured,
WBC
counts
collected
for
group
to
explore
association
health.
Results:
showed
significantly
worse
scores
compared
controls
(p
<
0.05).
positive
correlation
also
found
between
severity
disease
group.
Systemic
inflammation
factors
like
tyrosine
kinase
inhibitor
(TKI)
therapy
may
contribute
this
decline.
Conclusion:
more
likely
develop
disease,
emphasizing
necessity
integrated
care
that
deal
both
oral
systemic
Comprehensive
treatment
education,
particularly
resource-limited
settings
Iraq,
essential
improving
overall
quality
life
these
patients.
Язык: Английский
The systemic inflammation response index as risks factor for all-cause and cardiovascular mortality among individuals with respiratory sarcopenia
BMC Pulmonary Medicine,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 26, 2025
Respiratory
sarcopenia
is
associated
with
poor
outcomes,
yet
effective
biomarkers
for
risk
stratification
remain
limited.
This
study
investigates
the
associations
between
complete
blood
count
(CBC)-derived
inflammatory
biomarkers,
including
neutrophil-to-lymphocyte
ratio
(NLR),
neutrophil-monocyte-to-lymphocyte
(NMLR),
and
systemic
inflammation
response
index
(SIRI)
both
all-cause
cardiovascular
mortality
in
patients
respiratory
sarcopenia.
We
conducted
a
cohort
analysis
of
1,673
adults
possible
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2007
to
2012,
follow-up
through
December
31,
2019.
Possible
was
assessed
via
peak
expiratory
flow
rate
(PEFR).
Multivariable
Cox
regression
models
evaluated
NLR,
NMLR,
SIRI,
adjusted
demographic,
socioeconomic,
health-related
covariates.
Additional
CBC-derived
(PLR,
dNLR,
MLR,
SII)
were
analysed,
mediation
albumin's
role
as
partial
mediator
mortality.
Over
median
116
months,
263
deaths
occurred,
68
causes.
Elevated
SIRI
significantly
increased
risks
emerged
strongest
predictor,
hazard
ratios
(HRs)
1.65
(95%
CI,
1.23–2.22)
3.18
1.83–5.53)
Albumin
partially
mediated
relationship
(12.1%).
are
sarcopenia,
demonstrating
highest
predictive
power.
Integrating
into
clinical
assessments
may
aid
identifying
high-risk
patients,
allowing
targeted
interventions.
Язык: Английский
Weight-adjusted waist index and its relationship with systemic inflammatory Index and metabolic indices in overweight and obese individuals: A cross-sectional study
Science Progress,
Год журнала:
2025,
Номер
108(2)
Опубликована: Апрель 1, 2025
Background
Obesity-
characterized
by
excessive
adiposity-
is
associated
with
various
comorbidities,
including
metabolic,
cardiovascular,
and
liver
diseases.
Chronic
low-grade
inflammation
a
key
factor
in
complications
obesity.
This
study
aimed
to
investigate
the
associations
between
systemic
inflammatory
indices
(SIIs)
weight-adjusted
waist
index
(WWI),
alongside
metabolic
function
biomarkers
overweight
obese
individuals.
Method
cross-sectional
included
350
or
participants
(body
mass
(BMI)
≥
25
kg/m
2
)
from
both
genders.
Weight,
height,
waist,
hip,
neck
circumferences
were
measured
BMI,
WWI,
ratios
of
height
(WHtR)
hip
(WHR)
estimated.
Fasting
blood
samples
taken
assess
SII
as
well
parameters.
Results
In
this
study,
males
had
significantly
higher
weight
WC
compared
females,
whereas
mean
level
WWI
(p
<
0001)
WHtR
=
0.01)
women
greater
than
men.
A
significant
correlation
was
observed
(r
0.113,
p
0.039),
other
HbA1c
levels
−0.117,
0.033)
monocyte-to-lymphocyte
ratio
(MLR),
fasting
sugar
(FBS)
neutrophil-to-lymphocyte
NLR
0.110,
0.041).
quartiles
showed
differences
aspartate
aminotransferase
AST
0.001),
variations
MLR
also
−0.112,
0.043).
Conclusion
Our
results
reveal
strong
correlations
markers,
SII,
MLR,
PLR,
important
obesity
measures,
parameters
individuals
Язык: Английский
Pathological complete response and prognostic predictive factors of neoadjuvant chemoimmunotherapy in early stage triple-negative breast cancer
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 12, 2025
Neoadjuvant
chemoimmunotherapy
(nCIT)
has
shown
promise
in
treating
early-stage
triple-negative
breast
cancer
(eTNBC),
but
predictive
biomarkers
for
pathological
response
and
prognosis
remain
poorly
defined.
This
study
aimed
to
explore
complete
prognostic
factors
eTNBC
patients
treated
with
nCIT.
We
retrospectively
analyzed
112
who
underwent
surgery
after
nCIT
at
Sun
Yat-sen
University
Cancer
Center
between
June
2019
2023.
Pathological
was
assessed
using
Miller-Payne
grade.
Clinicopathological
features
hematologic
markers
were
univariate
multivariate
logistic
regression
or
Cox
regression,
as
well
Kaplan-Meier
survival
curves.
Objective
rate
(ORR),
(pCR),
disease-free
(DFS)
evaluated.
Nomograms
predicting
pCR
DFS
constructed
based
on
significant
risk
the
systemic
inflammatory
index
(SIRI).
Higher
baseline
lymphocyte
counts
(P=0.004)
independently
associated
a
higher
rate,
while
elevated
monocyte
(P=0.006),
neutrophil-to-lymphocyte
ratio
(P=0.005),
platelet-to-lymphocyte
(p
=
0.005),
SIRI
(P=0.037),
immune-inflammation
(P=0.029),
preoperative
(P=0.010)
lower
rate.
(P=
0.009)
correlated
shorter
DFS,
(P=0.019)
predicted
longer
DFS.
incorporating
showed
high
accuracy
Hematologic
markers,
particularly
SIRI,
are
cost-effective
reliable
predictors
of
treatment
efficacy
undergoing
nCIT,
helping
clinicians
develop
personalized
strategies.
https://www.medicalresearch.org.cn/,
identifier
MR-44-24-046099.
Язык: Английский
Development and validation of a machine learning model based on complete blood counts to predict clinical outcomes in urothelial carcinoma patients
Clinica Chimica Acta,
Год журнала:
2025,
Номер
unknown, С. 120367 - 120367
Опубликована: Май 1, 2025
Язык: Английский
MBG/BSA Bone Grafts Immunomodulate Bone Regeneration by Releasing Bioactive Ions in Inflammatory Bone Defects
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
Abstract
Since
the
diseases
that
cause
bone
defects
are
mostly
inflammatory
diseases,
current
grafts
unable
to
effectively
regulate
osteoimmune
activity,
leading
impaired
osteogenesis
and
unfavorable
regeneration.
In
this
study,
inspired
by
composition,
biomimetic
mesoporous
bioactive
glass
nanoparticle
(MBG)/bovine
serum
albumin
(BSA)
designed
for
defects.
Systematically,
MBG/BSA
evaluated
characterization,
bioactivity,
anti‐inflammatory,
antioxidant
osteogenic
activity.
proved
be
biocompatible
can
release
ions
including
calcium
silicon
in
a
sustained
manner.
Furthermore,
reprograms
macrophage
phenotype
toward
anti‐inflammation
is
beneficial
The
antioxidative
activity
also
validated
under
inflammation
mechanism
may
via
interleukin‐4
(IL‐4)/Signal
transducer
activator
of
transcription
6
(STAT6)
pathway.
differentiation
mineralization
facilitated
due
improved
immunoregulation
MBG/BSA.
Overall,
work
suggests
with
immunomodulatory
properties
an
ideal
material
regeneration
application.
Язык: Английский
Correlation between systemic immune-inflammatory index and graded diagnosis of periodontitis: a combined cross-sectional and retrospective study
BMC Oral Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 23, 2024
To
investigate
the
association
between
periodontitis
and
inflammatory
biomarkers,
including
systemic
immune-inflammatory
index
(SII),
neutrophil-to-lymphocyte
ratio,
platelet-to-lymphocyte
lymphocyte-to-monocyte
ratio.
Our
study
comprised
a
cross-sectional
analysis
(an
indirect
evidence
group
periodontal
health
control
from
January
to
October
2023)
retrospective
(a
direct
non-maintenance
2014
March
2022).
We
analyzed
demographic
data,
imaging
measurements,
peripheral
blood
counts.
The
included
131
participants
in
group,
132
healthy
123
76
group.
exhibited
significantly
altered
biomarker
levels
compared
controls.
Receiver
operating
characteristic
curve
indicated
that
SII
was
most
effective
for
diagnosing
periodontitis,
with
an
area
under
0.758
Youden
0.409.
optimal
cut-off
value
437.07
×
10⁹/L,
achieving
sensitivity
46.2%
specificity
94.7%.
Correlation
analyses
revealed
significant
associations
grades,
showing
highest
correlation
coefficient
(0.942).
In
supportive
therapy
mitigated
changes
these
biomarkers.
An
level
exceeding
109/L
could
facilitate
diagnosis
disease
grade
determination.
can
be
utilized
assess
monitor
severity
treatment
response.
Язык: Английский