Reviews in Aquaculture, Год журнала: 2022, Номер 15(2), С. 404 - 408
Опубликована: Окт. 3, 2022
Data sharing is not applicable to this article as no new data were created or analyzed in study.
Язык: Английский
Aquaculture and Fisheries, Год журнала: 2024, Номер unknown
Опубликована: Июль 1, 2024
Aquaculture, a critical sector for global food security, faces the challenge of meeting growing demand while protecting wild fish populations. Gene editing, powerful genetic tool, emerges as potential solution. By modifying key genes in fish, it is expected to rapidly enhance growth rate, disease resistance, and other economically important traits, leading increased profitability, sustainability, competitiveness industry. This review navigates complex landscape gene editing aquaculture, exploring successes, challenges, prospects improved productivity, resilience. We provide guidance researchers stakeholders identifying responsible addressing economic, environmental, regulatory, ethical considerations. roadmap paves way future where empowers aquaculture meet needs upholding environmental responsibility.
Язык: Английский
Процитировано
7
Agriculture Communications, Год журнала: 2024, Номер 2(2), С. 100044 - 100044
Опубликована: Июнь 1, 2024
Antimicrobial peptides (AMPs) show promise in enhancing resistance against pathogens. Previously, we integrated two AMP genes, cathelicidin (Cath) from alligator (Alligator mississippiensis or A. sinensis) and cecropin (Cec) moth (Hyalophora cecropia), into the channel catfish (Ictalurus punctatus) genome. This study examines efficacy of exogenous gene integration improving bacterial transgenic assesses direct pleiotropic effects replacement/knockout on survival growth based insertion site. Transgenic Cath- Cec-expressing fish exhibited similar higher rates (P > 0.05) compared to controls during initial culture. Integration Cec transgene doubled rate when challenged with Edwardsiella ictaluri, knock-in (KI) Cath further increasing resistance. Coupling KI mstn knockout (KO) increased 3-fold after E. ictaluri infection by 50% at 4 months post-fertilization (mpf). However, random had a minimal effect disease did not enhance growth. Random 2.5-fold 4-fold Flavobacterium covae, respectively, without affecting lh locus F. covae reduced 10% 24 mpf, whereas coupled mc4r KO resulted increase following controls, 80% 3 mpf. Simultaneous Cec, along mstn, while Dual genes yielded greatest disease. These may comprehension societal acceptance genetic engineering aquaculture.
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9299 - 9299
Опубликована: Авг. 27, 2024
Aquaculture, the world's fastest-growing food production sector, is critical for addressing security concerns because of its potential to deliver high-quality, nutrient-rich supplies by 2050. This review assesses effectiveness CRISPR/Cas9 genome editing technology in enhancing desirable traits fish species, including growth rates, muscle quality, disease resistance, pigmentation, and more. It also focuses on allowing precise targeted modifications DNA improve characteristics. Many studies have reported successful applications CRISPR/Cas9, such as knocking out reproductive genes control reproduction sex determination, feed conversion efficiency, reducing off-target effects. Additionally, this has contributed environmental sustainability nitrogen-rich waste improving nutritional composition fish. However, acceptance modified public consumers hindered regarding perception, ecological impacts, regulatory frameworks. To gain approval consumer confidence, clear communication about process, well data safety considerations genetically fish, are essential. paper discusses these challenges, provides possible solutions, recommends future research integration into sustainable aquaculture practices, focusing responsible management enable creation disease-resistant strains. In conclusion, highlights transformative traits, while considering challenges ethical associated with practices aquaculture.
Язык: Английский
Процитировано
6
Reviews in Aquaculture, Год журнала: 2022, Номер 14(4), С. 2002 - 2022
Опубликована: Май 2, 2022
Abstract Antimicrobial peptides (AMPs), also known as host defence peptides, are evolutionarily ancient defensive weapons that can combat infections caused by pathogens. Fish‐derived AMPs have shown microbicidal properties, immunomodulatory responses, and induced a variety of factors, especially pathogenic infection abiotic stress, which may activate downstream signalling pathways to initiate the expression antimicrobial peptide genes. Large‐scale genome sequencing has been applied in many aquatic animals, providing databases for systematic identification putative these species. Recently, whole proteome channel catfish ( Ictalurus punctatus ) were released; taking advantage database combining catfish, we established bioinformatic analysis pipeline identify AMP repertoire. This review introduces an effective method development based on protein datasets, summarizes structural immunomodulation molecular responses vivo AMPs. In addition, evaluation antibacterial activity synthetic or isolated vitro , applications fish via genetic engineering clustered regularly interspaced short palindromic repeats associated proteins system (CRISPR/Cas9) presented, supports research aquaculture therapy. The summary comparison will enhance our understanding their cross‐species applications. Combined with current editing techniques, it is possible promote immune processes protect valuable animals from infectious diseases.
Язык: Английский
Процитировано
25
Reviews in Aquaculture, Год журнала: 2022, Номер 15(1), С. 220 - 241
Опубликована: Июль 20, 2022
Abstract Aquaculture is the fastest‐growing food‐production sector and striving to become a long‐term sustainable approach meet rising global demand for seafood. During expansion advancement of aquaculture, minimizing ecological impacts should occur concomitantly with maximizing production. Farmed fish, often genetically distinct from their natural conspecifics, may pose significant risks genetic contamination imbalance wild populations if they escape aquaculture confinement. Growing reproductively sterile fish most effective way contain farmed fish. Atlantic salmon ( Salmo salar ) events in ‘Pacific Northwest’ region United States Canada have raised alarms over potential led legislation Washington State phasing out culture non‐native finfish species. Farming native species such as coho Oncorhynchus kisutch sablefish Anoplopoma fimbria Pacific Northwest would ease public concerns promote environmentally economically aquaculture. Sterile also can mitigate challenge precocious maturation, prominent issue associated salmonids many other species, improve somatic growth, flesh quality health welfare. Here, we review methods having applications producing introduce our novel immersion‐based technology that temporarily silences dead end dnd gene using Morpholino oligonucleotides produce first time. The successful induction sterility these two iconic without introducing modifications use this sterilization more worldwide.
Язык: Английский
Процитировано
23
Aquaculture, Год журнала: 2023, Номер 575, С. 739725 - 739725
Опубликована: Май 29, 2023
Язык: Английский
Процитировано
15
GM crops & food, Год журнала: 2024, Номер 15(1), С. 1 - 14
Опубликована: Янв. 12, 2024
This paper explores the scope for newly emerging technologies, based on gene editing (GE) contributing to addressing global challenges that we face. These relate food security, climate change and biodiversity depletion. In particular, it examines science evidence behind most appropriate forms of agricultural production meet these challenges, targets set in Global Biodiversity Framework (GBF) agreed at end 2022 possible role GE technologies meeting targets. It then risk-appropriate regulatory environment required best facilitate adoption technology, drawing experiences impact systems other innovations used such as genetically modified organisms (GMOs).
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129384 - 129384
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
5
Reviews in Aquaculture, Год журнала: 2025, Номер 17(3)
Опубликована: Апрель 1, 2025
ABSTRACT The potential benefits of enhancing the capacity for carbohydrate utilization in farmed fish, particularly species with pronounced intolerance, are significant from a number perspectives. In recent decades, multitude research initiatives have focused on elucidating factors that influence as well biological limitations constrain this process. Despite substantial progress achieved thus far, dearth clarity persists regarding associated tolerance among various species. Evidence suggests that, mammals, pancreatic islet tissues teleosts act regulatory valve glucose assimilation and metabolism. However, precise intricacies remain to be fully elucidated subject ongoing endeavors fish objective review is provide comprehensive evaluation extant gaps domain endocrinology, aim identifying potentially impede Furthermore, it incorporates advancements biology physiological functions homeostasis zebrafish model mammalian animals more overview future directions fish. addition, we present prospective avenues inquiry concomitant challenges achieve profound comprehension fundamental mechanisms precipitate intolerance This expected benefit researchers specializing study metabolism
Язык: Английский
Процитировано
0
Frontiers in Genome Editing, Год журнала: 2022, Номер 4
Опубликована: Март 17, 2022
The Sustainable Development Goals (SDGs) were launched in 2015, with the top three goals being poverty eradication, improved food security and increased human health. All 17 SDGs have a target achievement date of 2030. These are ambitious inspirational that require substantial innovation technology adoption for successful achievement. Innovations plant breeding substantially contributed to transforming efficiency production since mid 20th century, innovations emerging current millennium demonstrating enhanced potential improve crop yields, nutritional values crops environmental impacts. outcomes underpin several SDGs, but particular first three. As climate change is expected become increasingly variable, greater impacts on agriculture, ability ensure going be important, as higher yields directly contribute reducing poverty. This article reviews recent reports contributions from genome editing technologies terms yield, nutrition sustainability, highlighting their importance achieving leading SDGs.
Язык: Английский
Процитировано
22