Research Square (Research Square),
Год журнала:
2022,
Номер
unknown
Опубликована: Ноя. 21, 2022
Abstract
Pulmonary
fibrosis
(PF)
is
a
special
type
of
pulmonary
parenchymal
disease,
with
chronic,
progressive,
fibrosis,
high
mortality.
There
lack
safe,
effective,
and
affordable
treatment
methods.
Qilongtian
(QLT)
traditional
Chinese
prescription
that
composed
Panax
notoginseng,
Earthworm,
Rhodiola,
shows
the
remarkable
clinical
curative
effect
PF.
However,
mechanism
QLT
remains
to
be
clarified.
Therefore,
we
studied
effectivity
in
treating
Bleomycin
(BLM)
induced
PF
mice.
Our
studies
have
shown
significantly
reduced
inflammatory
injury,
hydroxyproline
content
collagen
deposition
lung
tissue
BLM
mice
downregulated
cytokine
related
inflammation
expression
on
mRNA
protein
level
To
identify
QLT,
Transcriptome
was
measured,
IL-17
signal
pathway
screened
out
for
further
research.
Further
indicated
CCL12,
CXCL5,
FOSL1,
MMP9
,
AREG
which
are
fibrosis-related
genes
pathway.
In
summary,
results
potential
preventing
progress
by
inhibiting
resulting
study
provides
novel
scientific
basis
represents
new
therapeutics
clinical.
Journal of Cellular and Molecular Medicine,
Год журнала:
2020,
Номер
24(21), С. 12341 - 12354
Опубликована: Окт. 13, 2020
Abstract
Viral
myocarditis
(VMC)
commonly
triggers
heart
failure,
for
which
no
specific
treatments
are
available.
This
study
aims
to
explore
the
role
of
long
non‐coding
RNA
(lncRNA)
maternally
expressed
3
(MEG3)
in
VMC.
A
VMC
mouse
model
was
induced
by
Coxsackievirus
B3
(CVB3).
Then,
MEG3
and
TNF
receptor‐associated
factor
6
(TRAF6)
were
silenced
microRNA‐223
(miR‐223)
over‐expressed
mice,
followed
determination
ventricular
ejection
fraction
(LVEF)
left
fractional
shortening
(LVFS).
Dual‐luciferase
reporter
assay
introduced
test
interaction
among
MEG3,
TRAF6
miR‐223.
Macrophages
isolated
from
cardiac
tissues
bone
marrow,
polarization
M1
or
M2
macrophages
induced.
expressions
components
NLRP3
inflammatory
body
(NLRP3,
ASC,
Caspase‐1),
markers
(CD86,
iNOS
TNF‐α)
(CD206,
Arginase‐1
Fizz‐1)
measured
following
silencing.
In
model,
levels
obviously
increased,
while
miR‐223
expression
significantly
reduced.
Down‐regulation
resulted
inhibition
promoting
negatively
correlated
with
miR‐223,
but
positively
expression.
Down‐regulations
up‐regulation
observed
increase
weight,
survival
rate,
LVEF
LVFS,
inhibiting
inflammation
via
NF‐κB
pathway
inactivation
mice.
decreased
macrophage
elevated
up‐regulating
Collectively,
down‐regulation
leads
induces
miR‐223/TRAF6/NF‐κB
axis,
thus
alleviating
Reviews in Cardiovascular Medicine,
Год журнала:
2025,
Номер
26(2)
Опубликована: Фев. 21, 2025
Hypertrophic
cardiomyopathy
(HCM)
is
the
most
prevalent
hereditary
cardiovascular
disorder,
characterised
by
left
ventricular
hypertrophy
and
cardiac
fibrosis.
Cardiac
fibroblasts,
transformed
into
myofibroblasts,
play
a
crucial
role
in
development
of
However,
interactions
between
cardiomyocytes,
immune
cells
are
considered
major
mechanisms
driving
fibrosis
progression.
While
disease
has
strong
genetic
background,
its
pathogenetic
remain
complex
not
fully
understood.
Several
signalling
pathways
implicated
development.
Among
these,
transforming
growth
factor-beta
angiotensin
II
frequently
studied
context
In
this
review,
we
summarise
current
evidence
on
involvement
pathogenesis
HCM.
Additionally,
discuss
potential
monitoring
pro-fibrotic
molecules
predicting
clinical
outcomes
patients
with
Journal of Thoracic Oncology,
Год журнала:
2020,
Номер
15(7), С. e101 - e103
Опубликована: Апрель 27, 2020
The
coronavirus
disease
2019
outbreak
is
evolving
rapidly
worldwide.
lungs
are
the
target
of
primary
infection
and
patients
with
lung
cancer
seem
to
have
a
poor
prognosis.
To
our
knowledge,
this
first
reported
investigation
possible
role
interleukin-17
therapy
in
concomitant
severe
acute
respiratory
syndrome–coronavirus-2
infection.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 25, 2022
In
this
study,
we
investigated
the
effects
of
intestinal
alkaline
phosphatase
(IAP)
in
controlled
inflammation
and
alleviated
associated
insulin
resistance
(IR).
We
also
explored
possible
underlying
molecular
mechanisms,
showed
preventive
effect
IAP
on
IR
vivo,
verified
dephosphorylation
for
inhibition
vitro.
Furthermore,
examined
role
induced
by
a
high-fat
diet
mice.
found
that
an
+
enhancer
significantly
ameliorated
blood
glucose,
insulin,
low-density
lipoprotein,
gut
barrier
function,
inflammatory
markers,
lipopolysaccharide
(LPS)
serum.
could
dephosphorylate
LPS
nucleoside
triphosphate
pH-dependent
manner
Firstly,
is
inactivated
reduces
LPS-induced
inflammation.
Secondly,
adenosine,
dephosphorylated
product
adenosine
triphosphate,
elicited
anti-inflammatory
binding
to
A2A
receptor,
which
inhibits
NF-κB,
TNF,
PI3K-Akt
signalling
pathways.
Hence,
can
be
used
as
natural
agent
reduce
inflammation-induced
IR.
Biomedicines,
Год журнала:
2021,
Номер
9(8), С. 1002 - 1002
Опубликована: Авг. 12, 2021
In
patients
with
liver
cirrhosis,
minimal
hepatic
encephalopathy
(MHE)
is
triggered
by
a
shift
in
peripheral
inflammation,
promoting
lymphocyte
infiltration
into
the
brain.
Rifaximin
improves
neurological
function
MHE
normalizing
inflammation.
Patients
who
died
steatohepatitis
showed
T-lymphocyte
and
neuroinflammation
cerebellum,
suggesting
that
may
already
occur
these
patients.
The
aims
of
this
work
were
to
assess,
rat
model
mild
damage
similar
steatohepatitis,
whether:
(1)
rats
show
impaired
motor
coordination
early
phases
damage;
(2)
associated
changes
immune
system
cells
brain;
(3)
rifaximin
incoordination,
improved
reduced
restoration
alterations
neurotransmission.
Liver
was
induced
carbon
tetrachloride
(CCl4)
injection
over
four
weeks.
Peripheral
cell
infiltration,
neuroinflammation,
neurotransmission
cerebellum
assessed.
Mild
induces
altered
incoordination.
These
are
increased
TNFa,
CCL20,
CX3CL1
plasma
IL-17
IL-15
plasma,
CCL2
cerebellum.
This
promotes
macrophage
Early
treatment
prevents
report
provides
new
clues
regarding
mechanisms
beneficial
effects
rifaximin,
could
prevent
impairment
steatohepatitis.
