Compact and cost-effective laser-powered speckle contrast optical spectroscopy fiber-free device for measuring cerebral blood flow

Journal of Biomedical Optics, Год журнала: 2024, Номер 29(06)

Опубликована: Май 31, 2024

SignificanceIn the realm of cerebrovascular monitoring, primary metrics typically include blood pressure, which influences cerebral flow (CBF) and is contingent upon vessel radius. Measuring CBF noninvasively poses a persistent challenge, primarily attributed to difficulty accessing obtaining signal from brain.AimOur study aims introduce compact speckle contrast optical spectroscopy device for noninvasive measurements at long source-to-detector distances, offering cost-effectiveness, scalability while tracking (BF) with remarkable sensitivity temporal resolution.ApproachThe wearable sensor module consists solely laser diode board camera. It can be easily placed on subject's head measure BF sampling rate 80 Hz.ResultsCompared single-fiber-based version, proposed achieved gain about 70 times, showed superior stability, reproducibility, signal-to-noise ratio measuring distances. The distributed in multiple configurations around head.ConclusionsGiven its scalability, simplicity, this laser-centric tool offers significant potential advancing monitoring technologies.

Язык: Английский

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Normative cerebral microvascular blood flow waveform morphology assessed with diffuse correlation spectroscopy

Biomedical Optics Express, Год журнала: 2023, Номер 14(7), С. 3635 - 3635

Опубликована: Май 29, 2023

Microvascular cerebral blood flow exhibits pulsatility at the cardiac frequency that carries valuable information about cerebrovascular health. This study used diffuse correlation spectroscopy to quantify normative features of these waveforms in a cohort thirty healthy adults. We demonstrate they are sensitive changes vascular tone, as indicated by pronounced morphological with hypercapnia. Further, we observe significant sex-based differences waveform morphology, females exhibiting higher flow, greater area-under-the-curve, and lower pulsatility. Finally, values for critical closing pressure, i.e., minimum pressure required maintain given region.

Язык: Английский

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Epilepsy: Mitochondrial connections to the ‘Sacred’ disease

Mitochondrion, Год журнала: 2023, Номер 72, С. 84 - 101

Опубликована: Авг. 13, 2023

Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated biomarkers specific for myriad forms epilepsy makes diagnosis challenging. Diagnosis and monitoring childhood add to the need non-invasive biomarkers, especially when evaluating antiseizure medications. Although underlying mechanisms epileptogenesis are not fully understood, evidence mitochondrial involvement is substantial. Seizures affect 35%-60% patients diagnosed with diseases. Mitochondrial dysfunction pathophysiological in various epilepsies, including those non-mitochondrial origin. Decreased ATP production caused by malfunctioning brain cell mitochondria leads altered neuronal bioenergetics, metabolism neurological complications, Iron-dependent lipid peroxidation initiates ferroptosis, a death pathway that aligns morphology found neurodegenerative diseases (NDDs). Studies mouse genetic models seizure phenotypes where function an essential selenoprotein (GPX4) targeted suggest roles ferroptosis epilepsy. GPX4 pivotal NDDs, selenium protects interneurons ferroptosis. Selenium central nervous system micronutrient trace element. Low serum concentrations other elements minerals, iron, noted diagnosing supplements alleviate intractable seizures children reduced GPX activity. Copper cuproptosis, like iron link NDDs. Connecting these mechanistic pathways selenoproteins provides new insights into treating seizures, pointing using medicines prodrugs lipoic acid treat potential alternative therapeutic approaches transcranial magnetic stimulation (transcranial), photobiomodulation vagus nerve stimulation.

Язык: Английский

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Test-retest reliability of fNIRS in resting-state cortical activity and brain network assessment in stroke patients

Biomedical Optics Express, Год журнала: 2023, Номер 14(8), С. 4217 - 4217

Опубликована: Июль 7, 2023

Resting-state functional near infrared spectroscopy (fNIRS) scanning has attracted considerable attention in stroke rehabilitation research recent years. The aim of this study was to quantify the reliability fNIRS cortical activity intensity and brain network metrics among resting-state patients, comprehensively evaluate effects frequency selection, duration, analysis preprocessing strategies on test-retest reliability. Nineteen patients with underwent two resting sessions an interval 24 hours. haemoglobin signals were preprocessed by principal component analysis, common average reference haemodynamic modality separation (HMS) algorithm respectively. activity, connectivity level, local (degree, betweenness efficiency) global calculated at 25 scales × 16 time windows. each metric quantified intraclass correlation coefficient. results show that (1) high-frequency band higher ICC values than low-frequency band, is more reliable individual channel level when averaged within region channel, (2) above 4-minute scan are generally 0.5, efficiency reach high excellent levels after 4 min (0.5 < 0.9), moderate or even poor for degree (ICC 0.5), (3) HMS performs best improving values. indicate a duration minutes can lead most assessing function patients. It recommended use correction method HMS, reporting degree, single should be performed caution. This paper provides first comprehensive experimental design rehabilitation.

Язык: Английский

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Parkinson’s disease patients show delayed hemodynamic changes in primary motor cortex in fine motor tasks and decreased resting-state interhemispheric functional connectivity: a functional near-infrared spectroscopy study

Neurophotonics, Год журнала: 2024, Номер 11(02)

Опубликована: Май 29, 2024

SignificancePeople with Parkinson's disease (PD) experience changes in fine motor skills, which is viewed as one of the hallmark signs this disease. Due to its non-invasive nature and portability, functional near-infrared spectroscopy (fNIRS) a promising tool for assessing related skills.AimWe aim compare activation patterns primary cortex using fNIRS, comparing volunteers PD sex- age-matched control participants during task walking. Moreover, inter intrahemispheric connectivity (FC) was investigated resting state.ApproachWe used fNIRS measure hemodynamic elicited by finger-tapping 20 patients controls matched age, sex, education, body mass index. In addition, two-minute walking carried out. Resting-state FC also assessed.ResultsPatients showed delayed hypoactivation dominant hand hyperactivation non-dominant hand. The findings revealed significant correlations among various measures activity different cognitive clinical variables. There were no differences between task. However, there interhemispheric participants, statistically decrease compared participants.ConclusionsDecreased may day serve many potential neuroimaging biomarkers diagnosing PD.

Язык: Английский

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Neurocognitive and psychiatric symptoms following infection with COVID-19: Evidence from laboratory and population studies

Brain Behavior & Immunity - Health, Год журнала: 2023, Номер 28, С. 100595 - 100595

Опубликована: Янв. 23, 2023

The objective of the current investigation was to examine associations between symptomatic COVID-19 history, neurocognitive function, and psychiatric symptoms using cognitive task performance, functional brain imaging, a prospective population survey.

Язык: Английский

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Inefficient frontal and parietal brain activation during dual-task walking in a virtual environment in older adults

NeuroImage, Год журнала: 2023, Номер 273, С. 120070 - 120070

Опубликована: Апрель 1, 2023

Walking while performing an additional cognitive task (dual-task walking; DT walking) is a common yet highly demanding behavior in daily life. Previous neuroimaging studies have shown that performance declines from single-task (ST) to conditions are accompanied by increased prefrontal cortex (PFC) activity. This increment particularly pronounced older adults and has been explained either compensation, dedifferentiation, or inefficient processing fronto-parietal circuits. However, there only limited evidence for the hypothesized activity changes measured under real-life such as walking. In this study, we therefore assessed brain PFC parietal lobe (PL), investigate whether higher activation during walking related neural inefficiency. Fifty-six healthy (69.11 ± 4.19 years, 30 female) completed three tasks (treadmill at 1 m/s, Stroop task, Serial 3′s task) ST (Walking + Stroop, 3′s), baseline standing task. Behavioral outcomes were step time variability (Walking), Balance Integration Score BIS (Stroop), number of correct calculations S3corr (Serial 3′s). Brain was using functional near-infrared spectroscopy (fNIRS) over ventrolateral dorsolateral (vlPFC, dlPFC) inferior superior PL (iPL, sPL). Neurophysiological outcome measures oxygenated (HbO2) deoxygenated hemoglobin (HbR). Linear mixed models with follow-up estimated marginal means contrasts applied region-specific upregulations conditions. Furthermore, relationships DT-specific activations across all regions analyzed well relationship between behavioral DT. Data indicated expected upregulation DT-related more (particularly vlPFC) than regions. Activation increases positively correlated regions, predicted Results largely consistent both DTs (Stroop These findings likely suggest inefficiency dedifferentiation rather compensation adults. Findings implications interpreting promoting efficacy long-term interventions improve persons.

Язык: Английский

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Measuring acute effects of subanesthetic ketamine on cerebrovascular hemodynamics in humans using TD-fNIRS

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Июль 19, 2023

Abstract Quantifying neural activity in natural conditions (i.e. comparable to the standard clinical patient experience) during administration of psychedelics may further our scientific understanding effects and mechanisms action. This data facilitate discovery novel biomarkers enabling more personalized treatments improved outcomes. In this single-blind, placebo-controlled study with a non-randomized design, we use time-domain functional near-infrared spectroscopy (TD-fNIRS) measure acute brain dynamics after intramuscular subanesthetic ketamine (0.75 mg/kg) placebo (saline) healthy participants ( n = 15, 8 females, 7 males, age 32.4 ± 7.5 years) setting. We found that caused an altered state consciousness changes systemic physiology (e.g. increase pulse rate electrodermal activity). Furthermore, led brain-wide reduction fractional amplitude low frequency fluctuations, decrease global connectivity prefrontal region. Lastly, provide preliminary evidence combination physiological metrics serve as predictors subjective mystical experiences reductions depressive symptomatology. Overall, demonstrated successful application fNIRS neuroimaging psychoactive substance humans, can be regarded important step toward larger scale studies quantify impact on settings.

Язык: Английский

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Toward Workload-Based Adaptive Automation: The Utility of fNIRS for Measuring Load in Multiple Resources in the Brain

International Journal of Human-Computer Interaction, Год журнала: 2023, Номер 40(22), С. 7404 - 7430

Опубликована: Окт. 23, 2023

We investigate the utility of functional near-infrared spectroscopy (fNIRS) for workload-based adaptive automation through lens multiple resource theory. focus on criteria unobtrusiveness, responsiveness, load sensitivity (low vs high load), and diagnosticity (differentiating types load). report a large meta-review, in which we conclude that only few studies were suitable evaluating complex real-world tasks. While these reveal fNIRS signal is adequately sensitive to gradations level changes (sensitivity), different sources cognitive remained uncertain. manipulated mental shape sorting task via working memory (WM) visual perceptual (VL), while secondary auditory was present throughout. measured effect manipulations at group-level using conventional eyetracking workload measures, as well hemodynamic response specific regions brain, including involved multi-tasking (MT), VL, WM, (AL). Our findings revealed both diagnostic tasks, with greater by deoxyhemoglobin than oxyhemoglobin brain associated align neuroscience literature load, goal-directed multitasking.

Язык: Английский

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Lights on music cognition: A systematic and critical review of fNIRS applications and future perspectives

Brain and Cognition, Год журнала: 2024, Номер 180, С. 106200 - 106200

Опубликована: Июнь 21, 2024

Research investigating the neural processes related to music perception and production constitutes a well-established field within cognitive neurosciences. While most neuroimaging tools have limitations in studying complexity of musical experiences, functional Near-Infrared Spectroscopy (fNIRS) represents promising, relatively new tool for both laboratory ecological settings, which is also suitable typical pathological populations across development. Here we systematically review fNIRS studies on cognition, highlighting prospects potentialities. We include an overview basic theory, together with brief comparison characteristics other tools. Fifty-nine meeting inclusion criteria (i.e., using as primary stimulus) are presented five thematic sections. Critical discussion methodology leads us propose guidelines good practices aiming robust signal analyses reproducibility. A continuously updated world map proposed, including information from criteria. It provides organized, accessible, updatable reference database, could serve catalyst future collaborations community. In conclusion, shows potential music, particularly contexts special populations, aligning current research priorities cognition.

Язык: Английский

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