Ultrasound-Responsive Systems as Components for Smart Materials

Chemical Reviews, Год журнала: 2021, Номер 122(5), С. 5165 - 5208

Опубликована: Ноя. 12, 2021

Smart materials can respond to stimuli and adapt their responses based on external cues from environments. Such behavior requires a way transport energy efficiently then convert it for use in applications such as actuation, sensing, or signaling. Ultrasound carry safely with low losses through complex opaque media. It be localized small regions of space couple systems over wide range time scales. However, the same characteristics that allow ultrasound propagate make difficult acoustic into other useful forms. Recent work across diverse fields has begun address this challenge, demonstrating ultrasonic effects provide control physical chemical surprisingly high specificity. Here, we review recent progress ultrasound-matter interactions, focusing incorporated components smart materials. These techniques build fundamental phenomena cavitation, microstreaming, scattering, radiation forces enable capabilities payload delivery, initiation biological processes. The diversity emerging holds great promise supported by poses interesting questions further investigations.

Язык: Английский

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Wavefront shaping: A versatile tool to conquer multiple scattering in multidisciplinary fields

The Innovation, Год журнала: 2022, Номер 3(5), С. 100292 - 100292

Опубликована: Авг. 2, 2022

Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media. Most these implementations rely on the usage ballistic quasi-ballistic photons achieve high spatial resolution. However, inherent scattering nature light in biological tissues tissue-like media constitutes critical obstacle that has restricted penetration depth non-scattered and hence limited implementation most optical for wider applications. In addition, components an system are usually designed manufactured fixed function performance. Recent advances wavefront shaping have demonstrated scattering- component-induced phase distortions can be compensated by optimizing input pattern through iteration conjugating transmission matrix medium. This offers unprecedented opportunities many controllable delivery detection at depths dynamically configurable functionalities using substitute conventional components. this article, recent progress multidisciplinary fields is reviewed, from focusing imaging with media, functionalized devices, modulation mode coupling, nonlinearity multimode fiber fiber-based Apart insights into underlying principles implementations, practical limitations roadmap future development discussed depth. Looking back looking forward, it believed holds bright will open new avenues noninvasive minimally invasive arbitrary control inside deep tissues. The degree freedom multiple also develop novel devices based single medium (generic customized) outperform traditional

Язык: Английский

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Optophysiology: Illuminating cell physiology with optogenetics

Physiological Reviews, Год журнала: 2022, Номер 102(3), С. 1263 - 1325

Опубликована: Янв. 24, 2022

Optogenetics combines light and genetics to enable precise control of living cells, tissues, organisms with tailored functions. has the advantages noninvasiveness, rapid responsiveness, tunable reversibility, superior spatiotemporal resolution. Following initial discovery microbial opsins as light-actuated ion channels, a plethora naturally occurring or engineered photoreceptors photosensitive domains that respond at varying wavelengths ushered in next chapter optogenetics. Through protein engineering synthetic biology approaches, genetically encoded photoswitches can be modularly into scaffolds host cells myriad biological processes, well behavioral disease intervention vivo. Here, we summarize these optogenetic tools on basis their fundamental photochemical properties better inform chemical design principles. We also highlight exemplary applications opsin-free optogenetics dissecting cellular physiology (designated "optophysiology") describe current progress, future trends, wireless optogenetics, which enables remote interrogation physiological processes minimal invasiveness. This review is anticipated spark novel thoughts next-generation devices promise accelerate both basic translational studies.

Язык: Английский

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Anti-scattering light focusing by fast wavefront shaping based on multi-pixel encoded digital-micromirror device

Light Science & Applications, Год журнала: 2021, Номер 10(1)

Опубликована: Июль 20, 2021

Abstract Speed and enhancement are the two most important metrics for anti-scattering light focusing by wavefront shaping (WS), which requires a spatial modulator with large number of modulation modes fast speed response. Among commercial modulators, digital-micromirror device (DMD) is sole solution providing millions pattern rate higher than 20 kHz. Thus, it has potential to accelerate process high enhancement. Nevertheless, modulating in binary mode DMD restricts both seriously. Here, we propose multi-pixel encoded DMD-based WS method combining multiple micromirrors into single unit overcome drawbacks modulation. In addition, efficiently optimize wavefront, adopted separable natural evolution strategies (SNES), could carry out global search against noisy environment. Compared state-of-the-art method, proposed increased optimization focus factor 179 16, respectively. our demonstration, achieved 10 foci homogeneous brightness at formed W- S-shape patterns scattering medium. The experimental results suggest that will pave new avenue applications biomedical imaging, photon therapy, optogenetics, dynamic holographic display, etc.

Язык: Английский

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High-gain and high-speed wavefront shaping through scattering media

Nature Photonics, Год журнала: 2023, Номер 17(4), С. 299 - 305

Опубликована: Янв. 23, 2023

Язык: Английский

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Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo

Nature Protocols, Год журнала: 2023, Номер 18(12), С. 3787 - 3820

Опубликована: Ноя. 1, 2023

Light is used extensively in biological and medical research for optogenetic neuromodulation, fluorescence imaging, photoactivatable gene editing light-based therapies. The major challenge to the vivo implementation of methods deep-seated structures brain or internal organs limited penetration photons tissue. presence light scattering absorption has resulted development invasive techniques such as implantation optical fibers, insertion endoscopes surgical removal overlying tissues overcome attenuation deliver it deep into body. However, these procedures are highly make difficult reposition adjust illuminated area each animal. Here, we detail a noninvasive approach (termed 'deLight') tissue via systemically injected mechanoluminescent nanotransducers that can be gated by using focused ultrasound. This achieves localized emission with sub-millimeter resolution millisecond response times any vascularized organ living mice without requiring light-emitting devices. For example, deLight enables neuromodulation live craniotomy implants. provides generalized method applications require source vivo, deep-brain imaging genome editing. entire protocol an application takes ~1-2 weeks.

Язык: Английский

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Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

APL Photonics, Год журнала: 2018, Номер 3(10)

Опубликована: Июль 30, 2018

Multiple light scattering has been regarded as a barrier in imaging through complex media such biological tissues. Owing to recent advances wavefront shaping techniques, optical intact tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities vivo and diagnosis. Although most of the proof principle breakthroughs have achieved laboratory setting with specialties physics engineering, we anticipate that these technologies translated laboratories clinical settings, which will revolutionize how diagnose treat disease. To provide insight into physical enables control multiple recently developed techniques improve bioimaging thick tissues, summarize progress on controlling

Язык: Английский

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Light scattering control in transmission and reflection with neural networks

Optics Express, Год журнала: 2018, Номер 26(23), С. 30911 - 30911

Опубликована: Ноя. 9, 2018

Scattering often limits the controlled delivery of light in applications such as biomedical imaging, optogenetics, optical trapping, and fiber-optic communication or imaging.Such scattering can be by appropriately shaping wavefront entering material.Here, we develop a machine-learning approach for control.Using pairs binary intensity patterns measurements train neural networks (NNs) to provide corrections necessary shape beam after scatterer.Additionally, demonstrate that NNs used find functional relationship between transmitted reflected speckle patterns.Establishing validity this relationship, focus scan transmission through opaque media using light.Our shows versatility shaping, efficiently flexibly correcting scattering, particular feasibility control based on light.

Язык: Английский

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The Red Edge: Bilin-Binding Photoreceptors as Optogenetic Tools and Fluorescence Reporters

Chemical Reviews, Год журнала: 2021, Номер 121(24), С. 14906 - 14956

Опубликована: Окт. 20, 2021

This review adds the bilin-binding phytochromes to Chemical Reviews thematic issue "Optogenetics and Photopharmacology". The work is structured into two parts. We first outline photochemistry of covalently bound tetrapyrrole chromophore summarize relevant spectroscopic, kinetic, biochemical, physiological properties different families phytochromes. Based on this knowledge, we then describe engineering further improve these chromoproteins as photoswitches their employment in an ever-growing number optogenetic applications. Most applications rely light-controlled complex formation between plant photoreceptor PhyB phytochrome-interacting factors (PIFs) or C-terminal light-regulated domains with enzymatic functions present many bacterial algal Phytochrome-based tools are currently implemented bacteria, yeast, plants, animals achieve light control a wide range biological activities. These cover regulation gene expression, protein transport cell organelles, recruitment phytochrome- PIF-tagged proteins membranes other cellular compartments. compilation illustrates intrinsic advantages compared classes, e.g., bidirectional dual-wavelength enabling instant ON OFF regulation. In particular, long wavelength absorption fluorescence within "transparent window" makes attractive for requiring deep tissue penetration combination blue UV light-sensing photoreceptors. addition variability employing natural engineered phytochromes, also discuss recent progress development bilin-based fluorescent proteins.

Язык: Английский

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Depth-targeted energy delivery deep inside scattering media

Nature Physics, Год журнала: 2022, Номер 18(3), С. 309 - 315

Опубликована: Янв. 27, 2022

Язык: Английский

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