Ultrasound-Responsive Systems as Components for Smart Materials

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(5), P. 5165 - 5208

Published: Nov. 12, 2021

Smart materials can respond to stimuli and adapt their responses based on external cues from environments. Such behavior requires a way transport energy efficiently then convert it for use in applications such as actuation, sensing, or signaling. Ultrasound carry safely with low losses through complex opaque media. It be localized small regions of space couple systems over wide range time scales. However, the same characteristics that allow ultrasound propagate make difficult acoustic into other useful forms. Recent work across diverse fields has begun address this challenge, demonstrating ultrasonic effects provide control physical chemical surprisingly high specificity. Here, we review recent progress ultrasound-matter interactions, focusing incorporated components smart materials. These techniques build fundamental phenomena cavitation, microstreaming, scattering, radiation forces enable capabilities payload delivery, initiation biological processes. The diversity emerging holds great promise supported by poses interesting questions further investigations.

Language: Английский

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Wavefront shaping: A versatile tool to conquer multiple scattering in multidisciplinary fields

The Innovation, Journal Year: 2022, Volume and Issue: 3(5), P. 100292 - 100292

Published: Aug. 2, 2022

Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media. Most these implementations rely on the usage ballistic quasi-ballistic photons achieve high spatial resolution. However, inherent scattering nature light in biological tissues tissue-like media constitutes critical obstacle that has restricted penetration depth non-scattered and hence limited implementation most optical for wider applications. In addition, components an system are usually designed manufactured fixed function performance. Recent advances wavefront shaping have demonstrated scattering- component-induced phase distortions can be compensated by optimizing input pattern through iteration conjugating transmission matrix medium. This offers unprecedented opportunities many controllable delivery detection at depths dynamically configurable functionalities using substitute conventional components. this article, recent progress multidisciplinary fields is reviewed, from focusing imaging with media, functionalized devices, modulation mode coupling, nonlinearity multimode fiber fiber-based Apart insights into underlying principles implementations, practical limitations roadmap future development discussed depth. Looking back looking forward, it believed holds bright will open new avenues noninvasive minimally invasive arbitrary control inside deep tissues. The degree freedom multiple also develop novel devices based single medium (generic customized) outperform traditional

Language: Английский

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Optophysiology: Illuminating cell physiology with optogenetics

Physiological Reviews, Journal Year: 2022, Volume and Issue: 102(3), P. 1263 - 1325

Published: Jan. 24, 2022

Optogenetics combines light and genetics to enable precise control of living cells, tissues, organisms with tailored functions. has the advantages noninvasiveness, rapid responsiveness, tunable reversibility, superior spatiotemporal resolution. Following initial discovery microbial opsins as light-actuated ion channels, a plethora naturally occurring or engineered photoreceptors photosensitive domains that respond at varying wavelengths ushered in next chapter optogenetics. Through protein engineering synthetic biology approaches, genetically encoded photoswitches can be modularly into scaffolds host cells myriad biological processes, well behavioral disease intervention vivo. Here, we summarize these optogenetic tools on basis their fundamental photochemical properties better inform chemical design principles. We also highlight exemplary applications opsin-free optogenetics dissecting cellular physiology (designated "optophysiology") describe current progress, future trends, wireless optogenetics, which enables remote interrogation physiological processes minimal invasiveness. This review is anticipated spark novel thoughts next-generation devices promise accelerate both basic translational studies.

Language: Английский

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Anti-scattering light focusing by fast wavefront shaping based on multi-pixel encoded digital-micromirror device

Light Science & Applications, Journal Year: 2021, Volume and Issue: 10(1)

Published: July 20, 2021

Abstract Speed and enhancement are the two most important metrics for anti-scattering light focusing by wavefront shaping (WS), which requires a spatial modulator with large number of modulation modes fast speed response. Among commercial modulators, digital-micromirror device (DMD) is sole solution providing millions pattern rate higher than 20 kHz. Thus, it has potential to accelerate process high enhancement. Nevertheless, modulating in binary mode DMD restricts both seriously. Here, we propose multi-pixel encoded DMD-based WS method combining multiple micromirrors into single unit overcome drawbacks modulation. In addition, efficiently optimize wavefront, adopted separable natural evolution strategies (SNES), could carry out global search against noisy environment. Compared state-of-the-art method, proposed increased optimization focus factor 179 16, respectively. our demonstration, achieved 10 foci homogeneous brightness at formed W- S-shape patterns scattering medium. The experimental results suggest that will pave new avenue applications biomedical imaging, photon therapy, optogenetics, dynamic holographic display, etc.

Language: Английский

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High-gain and high-speed wavefront shaping through scattering media

Nature Photonics, Journal Year: 2023, Volume and Issue: 17(4), P. 299 - 305

Published: Jan. 23, 2023

Language: Английский

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Depth-targeted energy delivery deep inside scattering media

Nature Physics, Journal Year: 2022, Volume and Issue: 18(3), P. 309 - 315

Published: Jan. 27, 2022

Language: Английский

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Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo

Nature Protocols, Journal Year: 2023, Volume and Issue: 18(12), P. 3787 - 3820

Published: Nov. 1, 2023

Light is used extensively in biological and medical research for optogenetic neuromodulation, fluorescence imaging, photoactivatable gene editing light-based therapies. The major challenge to the vivo implementation of methods deep-seated structures brain or internal organs limited penetration photons tissue. presence light scattering absorption has resulted development invasive techniques such as implantation optical fibers, insertion endoscopes surgical removal overlying tissues overcome attenuation deliver it deep into body. However, these procedures are highly make difficult reposition adjust illuminated area each animal. Here, we detail a noninvasive approach (termed 'deLight') tissue via systemically injected mechanoluminescent nanotransducers that can be gated by using focused ultrasound. This achieves localized emission with sub-millimeter resolution millisecond response times any vascularized organ living mice without requiring light-emitting devices. For example, deLight enables neuromodulation live craniotomy implants. provides generalized method applications require source vivo, deep-brain imaging genome editing. entire protocol an application takes ~1-2 weeks.

Language: Английский

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Acoustic hologram–induced virtual in vivo enhanced waveguide (AH-VIEW)

Science Advances, Journal Year: 2024, Volume and Issue: 10(7)

Published: Feb. 14, 2024

Optical imaging and phototherapy in deep tissues face notable challenges due to light scattering. We use encoded acoustic holograms generate three-dimensional fields within the target medium, enabling instantaneous robust modulation of volumetric refractive index, thereby noninvasively controlling trajectory light. Through this approach, we achieved a remarkable 24.3% increase tissue heating rate vitro photothermal effect tests on porcine skin. In vivo photoacoustic mouse brain vasculature exhibits an improved signal-to-noise ratio through intact scalp skull. These findings demonstrate that our strategy can effectively suppress scattering complex biological by inducing low-angle scattering, achieving effective depth reaching millimeter scale. The versatility extends its potential applications neuroscience, lithography, additive manufacturing.

Language: Английский

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深层生物组织光学技术发展及其应用（特邀）

Chinese Journal of Lasers, Journal Year: 2024, Volume and Issue: 51(1), P. 0107003 - 0107003

Published: Jan. 1, 2024

光学技术在生物医学中扮演着越来越重要的角色,其非电离辐射、高分辨率、高对比度和对生物组织异变高度灵敏等特性使其非常适用于生物组织的研究,包括成像、传感、治疗、刺激以及控制等。然而由于光折射因子在生物组织中的分布是不均匀的,光在生物组织中的传播会受到很强的散射影响,故纯光学技术的穿透深度和空间分辨率是"鱼和熊掌不可兼得";高分辨率光学成像应用仅限于样品浅表层,当成像深度增加时分辨率急剧下降。实现光在深层生物组织里的高分辨率成像或应用是人们期盼已久的目标。近年来,为解决这一问题,研究者提出了不同的方法,例如切换到更长的光波长以减小组织散射系数,在信号检测时将漫射光转换为散射不明显的超声信号,逆转或者预先补偿由光的多次散射所带来的相位畸变,或借助光纤等微创光学通道实现深层生物组织的高分辨率光学成像、刺激等。基于团队在深层生物组织光学相关领域多年的耕耘,从光在生物组织中的传播特性出发,梳理和总结了近年来研究人员在光-声结合和光学波前整形技术等方面展开的诸多探索,以及在生物组织操控、成像、光学计算以及人工智能等领域中的应用尝试。虽然尚有诸多不足,但随着硬件设备的更新和计算技术的发展,在不远的将来有望实现活体深层生物组织光学高分辨率应用。在这一求索过程中,新方法和新能力将不断激发新的应用灵感,为光学尤其是生物医学光子学带来全新的理念和机遇。

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Perspective: Wavefront shaping techniques for controlling multiple light scattering in biological tissues: Toward in vivo applications

APL Photonics, Journal Year: 2018, Volume and Issue: 3(10)

Published: July 30, 2018

Multiple light scattering has been regarded as a barrier in imaging through complex media such biological tissues. Owing to recent advances wavefront shaping techniques, optical intact tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities vivo and diagnosis. Although most of the proof principle breakthroughs have achieved laboratory setting with specialties physics engineering, we anticipate that these technologies translated laboratories clinical settings, which will revolutionize how diagnose treat disease. To provide insight into physical enables control multiple recently developed techniques improve bioimaging thick tissues, summarize progress on controlling

Language: Английский

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