Light-controlled soft bio-microrobot

Light Science & Applications, Год журнала: 2024, Номер 13(1)

Опубликована: Фев. 26, 2024

Abstract Micro/nanorobots hold exciting prospects for biomedical and even clinical applications due to their small size high controllability. However, it is still a big challenge maneuver micro/nanorobots into narrow spaces with deformability adaptability perform complicated tasks. Here, we report light-controlled soft bio-microrobots (called “Ebot”) based on Euglena gracilis that are capable of performing multiple tasks in microenvironments including intestinal mucosa controllability, adaptability. The motion the Ebot can be precisely navigated via polygonal flagellum beating. Moreover, shows highly controlled different light illumination duration, which allows pass through curved microchannels With these features, Ebots able execute tasks, such as targeted drug delivery, selective removal diseased cells mucosa, well photodynamic therapy. This provides new bio-microrobotic tool, many possibilities task execution where conventional tools difficult access lack bio-adaptability.

Язык: Английский

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Shape Morphing of Hydrogels in Alternating Magnetic Field

ACS Applied Materials & Interfaces, Год журнала: 2019, Номер 11(23), С. 21194 - 21200

Опубликована: Май 22, 2019

Shape-morphing hydrogels have found a myriad of applications in biomimetics, soft robotics, and biomedical engineering. A magnetic field is favorable for specific hydrogels, since it noncontact biocompatible at high strengths. However, most magnetosensitive shape-morphing structures are made elastomers rather than because the magnetization usually too low to be actuated under static field. Here, we propose strategy achieve shape morphing hydrogels. We actuate magnetothermal sensitive by an alternating (AMF), where poly( N-isopropylacrylamide) can heated AMF undergo giant volume shrinkage temperature. design distributing pattern hydrogel strips on elastomer substrate realize various two-dimensional three-dimensional shapes such as heart-shape, truss, tube, helix. Complex origami been demonstrated using elastomer-magnetic hinges. further demonstrate combination navigation morphing, applying both direct The may open new opportunities functional

Язык: Английский

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Motility-Induced Temperature Difference in Coexisting Phases

Physical Review Letters, Год журнала: 2019, Номер 123(22)

Опубликована: Ноя. 26, 2019

Unlike in thermodynamic equilibrium where coexisting phases always have the same temperature, here we show that systems comprising ``active'' self-propelled particles can self-organize into two at different kinetic temperatures, which are separated from each other by a sharp and persistent temperature gradient. Contrasting previous studies focused on overdamped descriptions of active particles, ``hot-cold coexistence'' occurs if only accounting for inertia, is significant, e.g., activated dusty plasmas, microflyers, whirling fruits, or beetles interfaces. Our results exemplify route to use create self-sustained gradient across phases. This phenomenon fundamentally beyond physics accompanied slow coarsening law with an exponent significantly smaller than universal $1/3$ seen both Brownian particles.

Язык: Английский

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Micro/Nanoscale 3D Assembly by Rolling, Folding, Curving, and Buckling Approaches

Advanced Materials, Год журнала: 2019, Номер 31(36)

Опубликована: Июль 2, 2019

Abstract The miniaturization of electronics has been an important topic study for several decades. established roadmaps following Moore's Law have encountered bottlenecks in recent years, as planar processing techniques are already close to their physical limits. To bypass some the intrinsic challenges technologies, more and efforts devoted development 3D electronics, through either direct fabrication or indirect assembly. Recent research into focused on transistor technologies heterogeneous integration schemes, but these typically constrained by accessible range sophisticated geometries complexity processes. As alternative route, assembly methods make full use mature form predefined 2D precursor structures desired materials sizes, which then transformed targeted mesostructures mechanical deformation. latest progress area micro/nanoscale assembly, covering various classes rolling, folding, curving, buckling is discussed, focusing design concepts, principles, applications different methods, followed outlook remaining open opportunities.

Язык: Английский

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Stimuli-Responsive Actuator Fabricated by Dynamic Asymmetric Femtosecond Bessel Beam for In Situ Particle and Cell Manipulation

ACS Nano, Год журнала: 2020, Номер 14(5), С. 5233 - 5242

Опубликована: Март 20, 2020

Microscale intelligent actuators capable of sensitive and accurate manipulation under external stimuli hold great promise in various fields including precision sensors biomedical devices. Current microactuators, however, are often limited to a multiple-step fabrication process multimaterials. Here, pH-triggered soft microactuator (<100 μm) with simple structure, one-step process, single material is proposed, which composed deformable hydrogel microstructures fabricated by an asymmetric femtosecond Bessel beam. To further explore the swelling–shrinking mechanism, porosity difference between expansion contraction states investigated. In addition, introducing dynamic holographic processing splicing method, more complex responsive (S-shaped, C-shaped, tortile chiral structures) rapidly fabricated, exhibit tremendous expected deformation characteristics. Finally, as proof concept, pH-responsive microgripper for situ capturing polystyrene (PS) particles neural stem cells rapidly. This flexible, designable, approach manufacturing actuator provides versatile platform micro-objects drug delivery.

Язык: Английский

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