TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair

Journal of Neuroinflammation, Год журнала: 2023, Номер 20(1)

Опубликована: Фев. 25, 2023

The repair of white matter injury is significant importance for functional recovery after ischemic stroke, and the up-regulation triggering receptors expressed on myeloid cells 2 (TREM2) stroke neuroprotective implicated in remyelination. However, lack effective therapies calls need to investigate regenerative process remyelination role rehabilitation therapy. This study sought whether how moderate physical exercise (PE) promotes oligodendrogenesis rats with transient middle cerebral artery occlusion (tMCAO).Male Sprague-Dawley (weighing 250-280 g) were subjected tMCAO. AAV-shRNA was injected into lateral ventricle silence Trem2 gene before operation. group started electric running cage training at 48 h Morris water maze novel object recognition test used evaluate cognitive function. Luxol fast blue staining, diffusion tensor imaging, electron microscopy observe myelin repair. Immunofluorescence staining applied proliferation differentiation oligodendrocyte precursor (OPCs). Expression key molecules detected using immunofluorescence quantitative real-time polymerase chain reaction, Western blotting, Enzyme-linked immunosorbent assay, respectively.PE exerted efects by modulating microglial state, promoting neurological function over 35 d while silencing expression suppressed aforementioned effects promoted PE. In addition, leveraging activin-A neutralizing antibody, we found a direct beneficial effect PE microglia-derived its subsequent mediated activin-A/Acvr axis.The present reveals which upregulation TREM2 factor oligodendrocytes regeneration. an therapeutic approach improving integrity alleviating deficits stroke.

Язык: Английский

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A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation

Frontiers in Human Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Июль 21, 2023

Rehabilitation approaches for individuals with neurologic conditions have increasingly shifted toward promoting neuroplasticity enhanced recovery and restoration of function. This review focuses on exercise strategies non-invasive neuromodulation techniques that target neuroplasticity, including transcranial magnetic stimulation (TMS), vagus nerve (VNS), peripheral (PNS). We chosen to focus due their greater potential integration into routine clinical practice. explore discuss the application these interventional in four neurological are frequently encountered rehabilitation settings: Parkinson’s Disease (PD), Traumatic Brain Injury (TBI), stroke, Spinal Cord (SCI). Additionally, we benefits combining rehabilitation, which has shown promise accelerating recovery. Our identifies studies demonstrate through combined selected patient populations. primarily motor aspects but also briefly address non-motor impacts conditions. identify gaps current literature barriers implementation highlight areas needing further research suggest avenues future investigation, aiming enhance personalization unique neuroplastic responses associated each condition. serves as a resource professionals researchers seeking comprehensive understanding interventions tailored specific diseases diagnoses.

Язык: Английский

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Exoskeleton-Assisted Rehabilitation and Neuroplasticity in Spinal Cord Injury

World Neurosurgery, Год журнала: 2024, Номер 185, С. 45 - 54

Опубликована: Фев. 5, 2024

Язык: Английский

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Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 22, 2025

Physical exercise effectively prevents anxiety disorders caused by environmental stress. The neural circuitry mechanism, however, remains incomplete. Here, we identified a previously unrecognized pathway originating from the primary motor cortex (M1) to medial prefrontal (mPFC) via ventromedial thalamic (VM) nuclei in male mice. Besides anatomical evidence, both ex vivo and recordings showed enhanced excitability of M1-VM inputs prelimbic (PrL) region mPFC upon 14-day treadmill on chronic restraint stress (CRS) mouse model. Further functional interrogations demonstrated that activation this circuit is necessary sufficient direct anxiolytic effect training CRS Our findings provide more insights into circuits connecting mental regions under paradigm implicate potential targets for neuromodulation treating disorders. relieves disorders, while authors show input cortex, nuclei.

Язык: Английский

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The Impact of Aerobic Exercise on Depression in Young People: A Meta regression and Meta-analysis

Psychology of sport and exercise, Год журнала: 2025, Номер unknown, С. 102803 - 102803

Опубликована: Янв. 1, 2025

Язык: Английский

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Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia

Neurochemical Research, Год журнала: 2025, Номер 50(2)

Опубликована: Март 1, 2025

Язык: Английский

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The New Phytocomplex AL0042 Extracted from Red Orange By-Products Inhibits the Minimal Hepatic Encephalopathy in Mice Induced by Thioacetamide

Biomedicines, Год журнала: 2025, Номер 13(3), С. 686 - 686

Опубликована: Март 11, 2025

Background/Objectives: Minimal hepatic encephalopathy (MHE) is a clinical condition characterized by neurological impairments, including brain inflammation, arising from the accumulation of toxic metabolites associated with liver dysfunction and leaky gut. This study investigated pharmacological activity new phytocomplex extracted red orange by-products (AL0042) using hydrodynamic cavitation consisting mixture pectin, polyphenols, essential oils. Methods: Preliminary in vitro studies evaluated impact on epithelial integrity (TEER) enterocytes challenged pro-inflammatory cocktail. The effect AL0042 was then model thioacetamide (TAA)-treated mice that mimics MHE. A group 8–10-week-old male C57BL/6 intraperitoneally injected TAA to establish MHE model. intervention received along (20 mg/kg, administered orally once daily for 7 days). At end treatment, rotarod test conducted evaluate motor ability, evaluation blood biochemical, liver, parameters. Results: In vitro, (250 μg/mL) partially recovered TEER values, although anti-inflammatory mechanisms played negligible role. vivo, compared control group, showed significant behavioral differences, together alterations plasma ammonia, serum TNF-α, ALT, AST, corticosterone levels, SOD activity. Moreover, histological data confirmed at level. Conclusions: treatment revealed therapeutic TAA-induced mouse model, curbing oxidative stress peripheral central thus suggesting its deserves be further studies.

Язык: Английский

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The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents

Frontiers in Neural Circuits, Год журнала: 2025, Номер 19

Опубликована: Март 21, 2025

Descending neural pathways to the spinal cord plays vital roles in motor control. They are often damaged by brain injuries such as stroke and trauma, which lead severe impairments. Due limited capacity for regeneration of circuits adult central nervous system, currently no essential treatments available complete recovery. Notably, accumulating evidence shows that residual descending dynamically reorganized after injury contribute Furthermore, recent technological advances cell-type classification manipulation have highlighted structural functional diversity these pathways. Here, we focus on three major pathways, namely, corticospinal tract from cerebral cortex, rubrospinal red nucleus, reticulospinal reticular formation, summarize current knowledge their structures functions, especially rodent models (mice rats). We then review discuss process patterns reorganization induced following injury, compensate lost connections Understanding basic properties each pathway principles induction outcome rewired will provide therapeutic insights enhance interactive rewiring multiple

Язык: Английский

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The modulation of post-translational modification of proteins by physical exercise to improve brain functions via affecting metabolic homeostasis

Brain Behavior and Immunity Integrative, Год журнала: 2025, Номер unknown, С. 100120 - 100120

Опубликована: Апрель 1, 2025

Язык: Английский

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Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning

Journal of Neuroscience, Год журнала: 2020, Номер 40(33), С. 6289 - 6308

Опубликована: Июль 10, 2020

Motor learning depends on synaptic plasticity between corticostriatal projections and striatal medium spiny neurons. Retrograde tracing from the dorsolateral striatum reveals that both layer II/III V neurons in motor cortex express BDNF as a potential regulator of male female mice. The number these BDNF-expressing cortical levels protein are highest juvenile mice when adult patterns shaped, while low. When trained by physical exercise adult, expression is reinduced, especially projection Reduced 3-month-old results impaired space memory preserved. These findings suggest activity regulates differentially layers afferents essential for learning. SIGNIFICANCE STATEMENT supply, regulation during II/III.

Язык: Английский

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