Cited by Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men

TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair DOI

Jinghui Xu, Liying Zhang, Mingyue Li

et al.

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Feb. 25, 2023

The repair of white matter injury is significant importance for functional recovery after ischemic stroke, and the up-regulation triggering receptors expressed on myeloid cells 2 (TREM2) stroke neuroprotective implicated in remyelination. However, lack effective therapies calls need to investigate regenerative process remyelination role rehabilitation therapy. This study sought whether how moderate physical exercise (PE) promotes oligodendrogenesis rats with transient middle cerebral artery occlusion (tMCAO).Male Sprague-Dawley (weighing 250-280 g) were subjected tMCAO. AAV-shRNA was injected into lateral ventricle silence Trem2 gene before operation. group started electric running cage training at 48 h Morris water maze novel object recognition test used evaluate cognitive function. Luxol fast blue staining, diffusion tensor imaging, electron microscopy observe myelin repair. Immunofluorescence staining applied proliferation differentiation oligodendrocyte precursor (OPCs). Expression key molecules detected using immunofluorescence quantitative real-time polymerase chain reaction, Western blotting, Enzyme-linked immunosorbent assay, respectively.PE exerted efects by modulating microglial state, promoting neurological function over 35 d while silencing expression suppressed aforementioned effects promoted PE. In addition, leveraging activin-A neutralizing antibody, we found a direct beneficial effect PE microglia-derived its subsequent mediated activin-A/Acvr axis.The present reveals which upregulation TREM2 factor oligodendrocytes regeneration. an therapeutic approach improving integrity alleviating deficits stroke.

Language: Английский

Citations

A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation DOI

Alexandra Evancho, William J. Tyler, Keith McGregor

et al.

Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 21, 2023

Rehabilitation approaches for individuals with neurologic conditions have increasingly shifted toward promoting neuroplasticity enhanced recovery and restoration of function. This review focuses on exercise strategies non-invasive neuromodulation techniques that target neuroplasticity, including transcranial magnetic stimulation (TMS), vagus nerve (VNS), peripheral (PNS). We chosen to focus due their greater potential integration into routine clinical practice. explore discuss the application these interventional in four neurological are frequently encountered rehabilitation settings: Parkinson’s Disease (PD), Traumatic Brain Injury (TBI), stroke, Spinal Cord (SCI). Additionally, we benefits combining rehabilitation, which has shown promise accelerating recovery. Our identifies studies demonstrate through combined selected patient populations. primarily motor aspects but also briefly address non-motor impacts conditions. identify gaps current literature barriers implementation highlight areas needing further research suggest avenues future investigation, aiming enhance personalization unique neuroplastic responses associated each condition. serves as a resource professionals researchers seeking comprehensive understanding interventions tailored specific diseases diagnoses.

Language: Английский

Citations

Exoskeleton-Assisted Rehabilitation and Neuroplasticity in Spinal Cord Injury DOI

HE Ya-na,

Yuxuan Xu,

Minghang Hai

et al.

World Neurosurgery, Journal Year: 2024, Volume and Issue: 185, P. 45 - 54

Published: Feb. 5, 2024

Language: Английский

Citations

The Impact of Aerobic Exercise on Depression in Young People: A Meta regression and Meta-analysis DOI

Qiushi Yang,

J. Wang,

Yanan Lu

et al.

Psychology of sport and exercise, Journal Year: 2025, Volume and Issue: unknown, P. 102803 - 102803

Published: Jan. 1, 2025

Language: Английский

Citations

Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit DOI

Zhihua Luo, Junlin Chen, Yuchu Liu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 22, 2025

Physical exercise effectively prevents anxiety disorders caused by environmental stress. The neural circuitry mechanism, however, remains incomplete. Here, we identified a previously unrecognized pathway originating from the primary motor cortex (M1) to medial prefrontal (mPFC) via ventromedial thalamic (VM) nuclei in male mice. Besides anatomical evidence, both ex vivo and recordings showed enhanced excitability of M1-VM inputs prelimbic (PrL) region mPFC upon 14-day treadmill on chronic restraint stress (CRS) mouse model. Further functional interrogations demonstrated that activation this circuit is necessary sufficient direct anxiolytic effect training CRS Our findings provide more insights into circuits connecting mental regions under paradigm implicate potential targets for neuromodulation treating disorders. relieves disorders, while authors show input cortex, nuclei.

Language: Английский

Citations

Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia DOI

Qing Zhang, Yangjie Xu, Haodong Luo

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: March 1, 2025

Language: Английский

Citations

The New Phytocomplex AL0042 Extracted from Red Orange By-Products Inhibits the Minimal Hepatic Encephalopathy in Mice Induced by Thioacetamide DOI

Loredana Vesci, Giulia Martinelli, Yongqiang Liu

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 686 - 686

Published: March 11, 2025

Background/Objectives: Minimal hepatic encephalopathy (MHE) is a clinical condition characterized by neurological impairments, including brain inflammation, arising from the accumulation of toxic metabolites associated with liver dysfunction and leaky gut. This study investigated pharmacological activity new phytocomplex extracted red orange by-products (AL0042) using hydrodynamic cavitation consisting mixture pectin, polyphenols, essential oils. Methods: Preliminary in vitro studies evaluated impact on epithelial integrity (TEER) enterocytes challenged pro-inflammatory cocktail. The effect AL0042 was then model thioacetamide (TAA)-treated mice that mimics MHE. A group 8–10-week-old male C57BL/6 intraperitoneally injected TAA to establish MHE model. intervention received along (20 mg/kg, administered orally once daily for 7 days). At end treatment, rotarod test conducted evaluate motor ability, evaluation blood biochemical, liver, parameters. Results: In vitro, (250 μg/mL) partially recovered TEER values, although anti-inflammatory mechanisms played negligible role. vivo, compared control group, showed significant behavioral differences, together alterations plasma ammonia, serum TNF-α, ALT, AST, corticosterone levels, SOD activity. Moreover, histological data confirmed at level. Conclusions: treatment revealed therapeutic TAA-induced mouse model, curbing oxidative stress peripheral central thus suggesting its deserves be further studies.

Language: Английский

Citations

The modulation of post-translational modification of proteins by physical exercise to improve brain functions via affecting metabolic homeostasis DOI

Li Zhang

Brain Behavior and Immunity Integrative, Journal Year: 2025, Volume and Issue: unknown, P. 100120 - 100120

Published: April 1, 2025

Language: Английский

Citations

Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning DOI

Thomas Andreska, Stefanie Rauskolb,

Nina Schukraft

et al.

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 40(33), P. 6289 - 6308

Published: July 10, 2020

Motor learning depends on synaptic plasticity between corticostriatal projections and striatal medium spiny neurons. Retrograde tracing from the dorsolateral striatum reveals that both layer II/III V neurons in motor cortex express BDNF as a potential regulator of male female mice. The number these BDNF-expressing cortical levels protein are highest juvenile mice when adult patterns shaped, while low. When trained by physical exercise adult, expression is reinduced, especially projection Reduced 3-month-old results impaired space memory preserved. These findings suggest activity regulates differentially layers afferents essential for learning. SIGNIFICANCE STATEMENT supply, regulation during II/III.

Language: Английский

Citations

Physical exercise promotes brain remodeling by regulating epigenetics, neuroplasticity and neurotrophins DOI

Juan Liang,

Huiqing Wang, Yan Zeng

et al.

Reviews in the Neurosciences, Journal Year: 2021, Volume and Issue: 32(6), P. 615 - 629

Published: Feb. 14, 2021

Abstract Exercise has been shown to have beneficial effects on brain functions in humans and animals. can improve memory learning age-related neurodegenerative diseases. In animal models, physical exercise regulates epigenetics, promotes synaptic plasticity hippocampal neurogenesis, the expression levels of neurotrophic factors, improves cognitive function. Therefore, is very important for rehabilitation remodeling. The purpose this review explore mechanisms by which exerts positive This knowledge implies that be used as a non-drug therapy neurological

Language: Английский

Citations