Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons DOI Creative Commons
Hermany Munguba,

Bidisha Chattopadhyaya,

Stephan Nilsson

и другие.

Journal of Neuroscience, Год журнала: 2021, Номер 41(43), С. 8876 - 8886

Опубликована: Сен. 9, 2021

Cortical parvalbumin-expressing (Pvalb + ) neurons provide robust inhibition to neighboring pyramidal neurons, crucial for the proper functioning of cortical networks. This class inhibitory undergoes extensive synaptic formation and maturation during first weeks after birth continue dynamically maintain their output throughout adulthood. While several transcription factors, such as Nkx2-1, Lhx6, Sox6, are known be necessary differentiation progenitors into Pvalb which transcriptional programs underlie postnatal maintenance neurons' innervation function remains largely unknown. Because Sox6 is continuously expressed in until adulthood, we used conditional knock-out strategies investigate its putative role mice both sexes. We found that early loss leads failure bouton growth, whereas later removal mature adult causes shrinkage already established boutons. Paired recordings between revealed reduced release probability increased rate output. Furthermore, lacking display expression full-length tropomyosin-receptor kinase B (TrkB), a key modulator GABAergic transmission. Once re-expressed TrkB was sufficient rescue morphologic phenotype. Finally, showed mRNA levels were by motor training. Our data thus suggest constitutive from SIGNIFICANCE STATEMENT These undergo However, it unknown neurons. Here, show factor cell-autonomously regulates leaving unaffected other maturational features this neuronal population.

Язык: Английский

BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons DOI Creative Commons

Guillermo Moya‐Alvarado,

Reynaldo Tiburcio‐Félix,

María Raquel Ibáñez

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Фев. 24, 2023

Brain-derived neurotrophic factor (BDNF) and its receptors tropomyosin kinase receptor B (TrkB) the p75 neurotrophin (p75) are primary regulators of dendritic growth in CNS. After being bound by BDNF, TrkB endocytosed into endosomes continue signaling within cell soma, dendrites, axons. We studied functional role BDNF axonal cortical neurons derived from different transgenic mice using compartmentalized cultures microfluidic devices. found that increased neuronal body a cAMP response element-binding protein (CREB)-dependent manner. These effects were dependent on but not activity. Dynein-dependent BDNF-TrkB-containing endosome transport was required for long-distance induction growth. Axonal CREB mTOR activity body, this increase both proteins general translation expression Arc, plasticity-associated gene, indicating BDNF-TrkB coordinating transcription genes whose products contribute to learning memory regulation.

Язык: Английский

Процитировано

62
The hormesis principle of neuroplasticity and neuroprotection DOI Creative Commons
Mark P. Mattson, Rehana K. Leak

Cell Metabolism, Год журнала: 2024, Номер 36(2), С. 315 - 337

Опубликована: Янв. 10, 2024

Язык: Английский

Процитировано

21
Neurotrophin signalling in the human nervous system DOI Creative Commons

Sarah Ateaque,

Spyros Merkouris, Yves‐Alain Barde

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2023, Номер 16

Опубликована: Июль 4, 2023

This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis relevance to the function dysfunction in human nervous system. It also deals measurements of BDNF levels highlights recent findings from our laboratory TrkB TrkC signalling neurons. These include ligand selectivity Trk activation by non-neurotrophin ligands. The ligand-induced down-regulation re-activation receptors is discussed.

Язык: Английский

Процитировано

27
Oligodendroglia are emerging players in several forms of learning and memory DOI Creative Commons
Maxime Munyeshyaka, R. Douglas Fields

Communications Biology, Год журнала: 2022, Номер 5(1)

Опубликована: Окт. 29, 2022

Abstract Synaptic plasticity is the fundamental cellular mechanism of learning and memory, but recent research reveals that myelin-forming glia, oligodendrocytes (OL), are also involved. They contribute in ways synaptic cannot, findings have not been integrated into established conceptual framework used field memory. OLs their progenitors involved long-term memory consolidation, working recall associative learning. to short-term non-associative by affecting transmission, intrinsic excitability axons, neural oscillations. Oligodendroglial involvement expands beyond system-wide network function, where precise spike time arrival oscillations critical information processing, storage, retrieval.

Язык: Английский

Процитировано

31
Revisiting the expression of BDNF and its receptors in mammalian development DOI Creative Commons
Eli‐Eelika Esvald, Jürgen Tuvikene, Carl Sander Kiir

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2023, Номер 16

Опубликована: Июнь 22, 2023

Brain-derived neurotrophic factor (BDNF) promotes the survival and functioning of neurons in central nervous system contributes to proper many non-neural tissues. Although regulation role BDNF have been extensively studied, a rigorous analysis expression dynamics its receptors TrkB p75NTR is lacking. Here, we analyzed more than 3,600 samples from 18 published RNA sequencing datasets, used over 17,000 GTEx, ~ 180 BrainSpan database, describe developing mammalian neural We show evolutionarily conserved patterns mRNA non-conserved alternative 5' exon usage. Finally, also increasing protein levels during murine brain development several In parallel, spatiotemporal pattern both murines humans. Collectively, our in-depth gives insight into signaling whole organism throughout life.

Язык: Английский

Процитировано

23
The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy DOI Creative Commons
Raed AlRuwaili, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

и другие.

Neurochemical Research, Год журнала: 2023, Номер 49(3), С. 533 - 547

Опубликована: Ноя. 25, 2023

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) implicated in pathogenesis epileptogenesis and epilepsy, BDNF may have neuroprotective effect against epilepsy. Thus, goal present review was to highlight protective detrimental roles In this review, we also try find relation with other signaling pathways cellular processes including autophagy, mTOR pathway, progranulin (PGN), α-Synuclein (α-Syn) which negatively positively regulate BDNF/tyrosine kinase receptor B (TrkB) pathway. Therefore, assessment levels epilepsy should be related neuronal types both preclinical clinical studies. conclusion, there strong controversy concerning potential role preclinical, molecular, studies are warranted regard.

Язык: Английский

Процитировано

20
EEG connectivity and BDNF correlates of fast motor learning in laparoscopic surgery DOI Creative Commons
Ahmet Omurtag, Caroline Sunderland, Neil J. Mansfield

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 3, 2025

This paper investigates the neural mechanisms underlying early phase of motor learning in laparoscopic surgery training, using electroencephalography (EEG), brain-derived neurotrophic factor (BDNF) concentrations and subjective cognitive load recorded from n = 31 novice participants during laparoscopy training. Functional connectivity was quantified inter-site clustering (ISPC) assessed NASA-TLX scores. The study identified frequency-dependent patterns correlated with BDNF expression. Gains performance were associated beta connectivity, particularly within prefrontal cortex between visual frontal areas, task execution (r − 0.73), predicted by delta initial rest episode 0.83). also found correlations BDNF, distinct topographic emphasizing left temporal visuo-frontal links. By highlighting shifts functional learning, linking them to brain plasticity mediated multimodal findings could inform development more effective training methods tailored interventions involving practice feedback.

Язык: Английский

Процитировано

1
Resting-state aperiodic neural dynamics predict individual differences in visuomotor performance and learning DOI
Maarten A. Immink, Zachariah R. Cross, Alex Chatburn

и другие.

Human Movement Science, Год журнала: 2021, Номер 78, С. 102829 - 102829

Опубликована: Июнь 15, 2021

Язык: Английский

Процитировано

38
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons DOI Creative Commons
Thomas Andreska, Patrick Lüningschrör, Daniel H. Wolf

и другие.

Cell Reports, Год журнала: 2023, Номер 42(6), С. 112575 - 112575

Опубликована: Май 29, 2023

Disturbed motor control is a hallmark of Parkinson's disease (PD). Cortico-striatal synapses play central role in learning and adaption, brain-derived neurotrophic factor (BDNF) from cortico-striatal afferents modulates their plasticity via TrkB striatal medium spiny projection neurons (SPNs). We studied the dopamine modulating sensitivity direct pathway SPNs (dSPNs) to BDNF cultures fluorescence-activated cell sorting (FACS)-enriched D1-expressing 6-hydroxydopamine (6-OHDA)-treated rats. DRD1 activation causes enhanced translocation surface increased for BDNF. In contrast, depletion cultured dSPN neurons, 6-OHDA-treated rats, postmortem brain patients with PD reduces responsiveness formation intracellular clusters. These clusters associate sortilin related VPS10 domain containing receptor 2 (SORCS-2) multivesicular-like structures, which apparently protects them lysosomal degradation. Thus, impaired processing might contribute disturbed function PD.

Язык: Английский

Процитировано

15
Reduced Levels of Brain-Derived Neurotrophic Factor Affect Body Weight, Brain Weight and Behavior DOI Creative Commons

M Voigt,

Jens Schepers,

Jacqueline Haas

и другие.

Biology, Год журнала: 2024, Номер 13(3), С. 159 - 159

Опубликована: Фев. 29, 2024

Neurotrophins, which belong to the family of growth factors, not only play crucial roles during development but are also involved in many processes postnatal brain. One representative neurotrophins is brain-derived neurotrophic factor (BDNF). BDNF plays a role regulation body weight and neuronal plasticity is, therefore, associated with learning memory formation. Many studies on have been carried out using BDNF-deficient mice. Unfortunately, homozygous deletion lethal early stage, so heterozygous mice often studied. Another possibility use conditional expression strongly downregulated some brain cells, for example, neurons central nervous system, other cells unchanged. To further reduce expression, we crossed carrying neurofilament L-positive neurons. These offspring viable, animals strong reduction show increased weight, accompanied by weight. In addition, these behavioral abnormalities, particularly regard locomotion.

Язык: Английский

Процитировано

6