Nanomedicine in cancer therapy

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Авг. 7, 2023

Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise to multiple undesired side effects. Recent advances nanotechnology, accompanied by our growing understanding of biology and nano-bio interactions, have led development series nanocarriers, which aim improve efficacy while reducing off-target toxicity encapsulated anticancer agents through tumor tissue-, cell-, organelle-specific targeting. However, vast majority nanocarriers do not possess hierarchical targeting capability, their indices often compromised poor accumulation, inefficient cellular internalization, inaccurate subcellular localization. This Review outlines current prospective strategies design organelle-targeted nanomedicines, highlights latest progress technologies can dynamically integrate these three different stages static maximize outcomes. Finally, we briefly discuss challenges future opportunities for clinical translation nanomedicines.

Язык: Английский

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Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy

Advanced Science, Год журнала: 2021, Номер 9(1)

Опубликована: Ноя. 19, 2021

Abstract The past decades have witnessed great progress in cancer immunotherapy, which has profoundly revolutionized oncology, whereas low patient response rates and potential immune‐related adverse events remain major clinical challenges. With the advantages of controlled delivery modular flexibility, nanomedicine offered opportunities to strengthen antitumor immune responses sensitize tumor immunotherapy. Furthermore, tumor‐microenvironment (TME)‐responsive been demonstrated achieve specific localized amplification tissue a safe effective manner, increasing immunotherapy reducing side effects simultaneously. Here, recent TME‐responsive for is summarized, responds signals TME, such as weak acidity, reductive environment, high‐level reactive oxygen species, hypoxia, overexpressed enzymes, adenosine triphosphate. Moreover, combine nanomedicine‐based therapy immunotherapeutic strategies overcome each step cancer‐immunity cycle enhance discussed. Finally, existing challenges further perspectives this rising field with hope improved development applications are

Язык: Английский

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Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

Bioactive Materials, Год журнала: 2021, Номер 8, С. 220 - 240

Опубликована: Июль 6, 2021

The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering "all-in-one" functional platform features. However, the native defects limit delivery release behavior throughout in vivo journey, which significantly compromise therapeutic efficacy hinder further cancer treatment. In this review, we summarized discussed recent strategies enhance drug for improved therapy, including optimizing intrinsic physicochemical properties external modification. Finally, corresponding challenges that faced are future perspectives its application presented. We hope review will provide constructive information rational design more effective advance

Язык: Английский

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Versatile polyphenolic platforms in regulating cell biology

Chemical Society Reviews, Год журнала: 2022, Номер 51(10), С. 4175 - 4198

Опубликована: Янв. 1, 2022

Polyphenolic materials are a class of fascinating and versatile bioinspired for biointerfacial engineering. In particular, due to the presence active chemical groups, series unique physicochemical properties become accessible tunable as-prepared polyphenolic platforms, which could delicately regulate cell activities via cell-material contact-dependent interactions. More interestingly, polyphenols also affect behaviors contact-independent manner, arise their intrinsically functional characteristics (e.g., antioxidant photothermal behaviors). As such, comprehensive understanding on relationship between material desired biomedical applications, as well underlying mechanism at cellular molecular level would provide design principles accelerate lab-to-clinic translation platforms. this review, we firstly give brief overview hallmarks governed by surrounding cues, followed introduction engineering strategies. Subsequently, detailed discussion cell-polyphenols interfacial interaction was carefully provided. Lastly, applications were elaborated. We believe that review guidances rational multifunctional extend application window.

Язык: Английский

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Tumor-Generated Reactive Oxygen Species Storm for High-Performance Ferroptosis Therapy

ACS Nano, Год журнала: 2023, Номер 17(12), С. 11492 - 11506

Опубликована: Июнь 7, 2023

Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the tumor environment (TME), which are unfavorable for reactive oxygen species (ROS) generation based on or Fenton-like reactions. The glutathione (GSH) overexpression TME can scavenge ROS abate FT performance. In this study, strategy storm specifically initiated by our developed nanoplatforms (TAF-HMON-CuP@PPDG) is proposed high-performance tumors. GSH initiates HMON degradation, resulting tamoxifen (TAF) copper (CuP) release TAF3-HMON-CuP3@PPDG. released TAF leads to enhanced acidification within cells, reacts with CuP producing Cu2+ H2O2. reaction between H2O2 generates Cu+, that Cu+ Cu2+, forming cyclic catalysis effect. generate GSSG. increased accelerate consumption decreases peroxidase 4 (GPX4) expression. All above reactions cells FT, demonstrated cancer tumor-bearing mice.

Язык: Английский

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GSH-Responsive Nanoprodrug to Inhibit Glycolysis and Alleviate Immunosuppression for Cancer Therapy

Nano Letters, Год журнала: 2021, Номер 21(18), С. 7862 - 7869

Опубликована: Сен. 8, 2021

Blocking energy metabolism of cancer cells and simultaneously stimulating the immune system to perform attack are significant for treatment. However, how potently deliver different drugs with these functions remains a challenge. Herein, we synthesized nanoprodrug formed by F127-coated drug dimer inhibit glycolysis alleviate immunosuppressive microenvironment. The was delicately constructed connect lonidamine (LND) NLG919 disulfide bond which can be cleaved excess GSH release two drugs. LND decrease expression hexokinase II destroy mitochondria restrain supply. reduce accumulation kynurenine number regulatory T cells, thus alleviating Notably, consumption increased intracellular oxidative stress triggered immunogenic cell death cells. This strategy offer more possibilities explore dimeric prodrugs synergistic therapy.

Язык: Английский

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Charge reversal nano-systems for tumor therapy

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Янв. 10, 2022

Abstract Surface charge of biological and medical nanocarriers has been demonstrated to play an important role in cellular uptake. Owing the unique physicochemical properties, charge-reversal delivery strategy rapidly developed as a promising approach for drug application, especially cancer treatment. Charge-reversal are neutral/negatively charged at physiological conditions while could be triggered positively by specific stimuli (i.e., pH, redox, ROS, enzyme, light or temperature) achieve prolonged blood circulation enhanced tumor uptake, thus potentiate antitumor effects delivered therapeutic agents. In this review, we comprehensively summarized recent advances nanocarriers, including: (i) effect surface on uptake; (ii) charge-conversion mechanisms responding several stimuli; (iii) relation between chemical structure reversal activity; (iv) polymeric materials that commonly applied systems. Graphical

Язык: Английский

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Dual‐Cascade Responsive Nanoparticles Enhance Pancreatic Cancer Therapy by Eliminating Tumor‐Resident Intracellular Bacteria

Advanced Materials, Год журнала: 2022, Номер 34(49)

Опубликована: Сен. 9, 2022

The limited drug penetration and robust bacteria-mediated inactivation in pancreatic cancer result the failure of chemotherapy. To fight against these issues, a dual-cascade responsive nanoparticle (sNP@G/IR) that can sequentially trigger deep penetration, killing intratumor bacteria, controlled release chemo-drug, is reported. sNP@G/IR consists hyaluronic acid (HA) shell glutathione (GSH)-responsive polymer-core (NP@G/IR), encapsulates gemcitabine (Gem) photothermal agent (IR1048). polymer core, as an antibiotic alternative, tailored to exert optimal antibacterial activity selectivity. actively homes on tumor due CD44 targeting HA shell, which subsequently degraded by hyaluronidase extracellular matrix. resultant NP@G/IR decreased size reversed charge facilitates penetration. After cellular endocytosis, exposed guanidine kills intracellular bacteria through disrupting cell membranes. Intracellular GSH further triggers cargo. Thus, protected Gem eventually induces apoptosis. Under laser irradiation, hyperthermia IR1048 helps elimination tumors bacteria. Moreover, activates immune response, thereby reinforcing anticancer capacity. Therefore, this eliminates tumor-resident augments delivery efficacy, providing new avenue for improving therapy.

Язык: Английский

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Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

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Controlling the biodistribution and clearance of nanomedicines

Nature Reviews Bioengineering, Год журнала: 2023, Номер 2(3), С. 214 - 232

Опубликована: Дек. 20, 2023

Язык: Английский

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