ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(7), С. 7345 - 7354
Опубликована: Апрель 4, 2024
Starvation
therapy
mediated
by
glucose
oxidase
is
a
widely
used
therapeutic
approach
for
tumor
treatment,
but
it
limited
the
simultaneous
drawbacks
of
weak
efficacy,
nonspecificity,
and
systemic
toxicity.
Thus,
combination
was
to
complement
strategy
anticancer
therapy.
On
basis
starvation
therapy,
we
designed
catalytic
model
nanosheets
with
biological
cascade
enzymes
synergizing
drugs.
In
short,
two
(glucose
horseradish
peroxidase)
are
covalently
immobilized
on
Ti3C2
MXene
nanosheet
enzyme
nanoreactor
formed
electrostatically
adsorbing
positive
charged
DOX.
Finally,
outer
layer
coated
hyaluronic
acid.
By
combining
oxidase-mediated
photothermal
chemotherapy,
have
achieved
effect
"killing
three
birds
one
stone"
dual
stimulation
response
endogenous
exogenous
sources
site.
This
method
not
only
achieves
targeting
cancer
cells
also
improves
toxicity
reduced
efficacy
realizes
synergistic
enhanced
reactions.
It
opens
up
new
path
research
nanomedicine.
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 6891 - 6952
Опубликована: Май 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Chemical Reviews,
Год журнала:
2024,
Номер
124(9), С. 5505 - 5616
Опубликована: Апрель 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(48), С. 26296 - 26307
Опубликована: Ноя. 21, 2023
Immunotherapy
of
triple-negative
breast
cancer
(TNBC)
has
an
unsatisfactory
therapeutic
outcome
due
to
immunologically
"cold"
microenvironment.
Fusobacterium
nucleatum
(F.
nucleatum)
was
found
be
colonized
in
tumors
and
responsible
for
the
immunosuppressive
tumor
microenvironment
metastasis.
Herein,
we
constructed
a
bacteria-derived
outer
membrane
vesicle
(OMV)-coated
nanoplatform
that
precisely
targeted
tissues
dual
killing
F.
cells,
thus
transforming
intratumor
bacteria
into
immunopotentiators
immunotherapy
TNBC.
The
as-prepared
nanoparticles
efficiently
induced
immunogenic
cell
death
through
Fenton-like
reaction,
resulting
enhanced
immunogenicity.
Meanwhile,
intratumoral
killed
by
metronidazole,
release
pathogen-associated
molecular
patterns
(PAMPs).
PAMPs
cooperated
with
OMVs
further
facilitated
maturation
dendritic
cells
subsequent
T-cell
infiltration.
As
result,
"kill
two
birds
one
stone"
strategy
warmed
up
cold
environment,
maximized
antitumor
immune
response,
achieved
efficient
therapy
TNBC
as
well
metastasis
prevention.
Overall,
this
based
on
microecology
distinction
normal
tissue
microbiome-induced
reversal
provides
new
insight
precise
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Фев. 7, 2024
Abstract
The
dynamic
protein
corona
formed
on
nanocarriers
has
been
revealed
to
strongly
affect
their
in
vivo
behaviors.
Precisely
manipulating
the
formation
of
may
provide
an
alternative
impetus
for
specific
drug
delivery.
Herein,
we
explore
role
glycosylated
polyhydroxy
polymer-modified
nanovesicles
(CP-LVs)
with
different
amino/hydroxyl
ratios
and
evolution.
CP-LVs
ratio
approximately
0.4
(CP
1
-LVs)
are
found
efficiently
suppress
immunoglobulin
adsorption
blood
livers,
resulting
prolonged
circulation.
Moreover,
CP
-LVs
adsorb
abundant
tumor
distinctive
proteins,
such
as
CD44
osteopontin
interstitial
fluids,
mediating
selective
cell
internalization.
proteins
transformation
environment
appears
be
affected
by
electrostatic
interaction
between
diverse
isoelectric
points.
Benefiting
from
surface
modification-mediated
regulation,
paclitaxel-loaded
demonstrate
superior
antitumor
efficacy
PEGylated
liposomes.
Our
work
offers
a
perspective
rational
surface-design
modulate
efficient
Advanced Materials,
Год журнала:
2022,
Номер
35(8)
Опубликована: Дек. 9, 2022
Tumor
metastases
and
reoccurrences
are
considered
the
leading
cause
of
cancer-associated
deaths.
While
highly
efficient
treatments
for
eradication
primary
tumors
have
been
developed,
treatment
secondary
or
metastatic
remains
poorly
accessible.
Over
past
years,
compounds
that
intervene
through
cyclic
GMP-AMP
synthase-stimulator
interferon
genes
(cGAS-STING)
signaling
pathway
against
tumor
emerged
with
potential
clinical
development.
stimulatory
DNAs
demonstrated
activation
this
pathway,
these
associated
poor
bioavailability,
stability,
cancer
selectivity,
hindering
their
use
therapeutic
applications.
Herein,
encapsulation
a
potent
chemotherapeutic
platinum(II)
complex
incorporation
DNA
strands
cGAS-STING
into
multimodal
tetrahedral
nanostructures
(84bp-TDNISD/56MESS
)
combined
chemotherapy
immunotherapy
is
reported.
It
found
84bp-TDNISD/56MESS
can
work
as
not
only
drug
delivery
carrier
toxins,
but
also
an
immunostimulant
agent
activate
STING
antitumor
immune
responses.
In
mouse
breast
model,
nanostructure
to
nearly
fully
eradicate
well
secondary/metastatic
tumors,
hence
demonstrating
its
translational
value.
Advanced Materials,
Год журнала:
2023,
Номер
35(33)
Опубликована: Май 19, 2023
Drug
combination
provides
an
efficient
pathway
to
combat
drug
resistance
in
bacteria
and
bacterial
biofilms.
However,
the
facile
methodology
construct
combinations
their
applications
nanocomposites
is
still
lacking.
Here
two-tailed
antimicrobial
amphiphiles
(T2
A2
)
composed
of
nitric
oxide
(NO)-donor
(diethylenetriamine
NONOate,
DN)
various
natural
aldehydes
are
reported.
T2
self-assemble
into
nanoparticles
due
amphiphilic
nature,
with
remarkably
low
critical
aggregation
concentration.
The
representative
cinnamaldehyde
(Cin)-derived
(Cin-T2
assemblies
demonstrate
excellent
bactericidal
efficacy,
notably
higher
than
free
Cin
DN.
Cin-T2
kill
multidrug-resistant
staphylococci
eradicate
biofilms
via
multiple
mechanisms,
as
proved
by
mechanism
studies,
molecular
dynamics
simulations,
proteomics,
metabolomics.
Furthermore,
rapidly
alleviate
inflammation
subsequent
murine
infection
models.
Together,
may
provide
efficient,
non-antibiotic
alternative
combating
ever-increasing
threat
drug-resistant
Advanced Materials,
Год журнала:
2023,
Номер
36(17)
Опубликована: Июль 20, 2023
Abstract
The
discovery
of
antibiotics
has
saved
millions
lives,
but
the
emergence
antibiotic‐resistant
bacteria
become
another
problem
in
modern
medicine.
To
avoid
or
reduce
overuse
antibacterial
treatments,
stimuli‐responsive
materials,
pathogen‐targeting
nanoparticles,
immunogenic
nano‐toxoids,
and
biomimetic
materials
are
being
developed
to
make
sterilization
better
smarter
than
conventional
therapies.
common
goal
smart
(SAMs)
is
increase
antibiotic
efficacy
function
via
an
mechanism
different
from
that
order
biological
properties
while
reducing
risk
drug
resistance.
research
development
SAMs
increasingly
interdisciplinary
because
new
designs
require
knowledge
fields
input/collaboration
scientists
fields.
A
good
understanding
energy
conversion
physiological
characteristics
cells
bacteria,
bactericidal
structures
components
nature
expected
promote
SAMs.
In
this
review,
importance
multidisciplinary
insights
for
emphasized,
latest
advances
categorized
discussed
according
pertinent
disciplines
including
science,
physiology,
biomimicry.
