Biofilm-induced
chronic
bacterial
infections
represent
a
significant
challenge
in
modern
medicine
due
to
their
resistance
conventional
antibiotic
treatments.
Although
photodynamic
therapy
(PDT)
has
emerged
as
promising
antibiotic-free
antibacterial
strategy,
the
hypoxic
condition
within
biofilms
and
lack
of
an
effective
local
drug
delivery
system
have
limited
clinical
effectiveness
photosensitizer
(PS)
agents.
Herein,
we
propose
type
charge
regulation-enhanced
I
PS-loaded
hydrogel
dressing
for
treating
biofilm
infection.
The
regulation
enables
multiple
alkylation
Nile
blue
(EB
series)
exhibit
substantially
improved
absorbance
(∼2-fold),
alkaline
tolerance,
superoxide
anion
yield
(2.2-4.2-fold)
compared
representative
PS,
sulfur-substituted
blue.
Specifically,
enhanced
electronic
push-pull
capabilities
promote
more
efficient
electron
recycling
process,
significantly
boosting
efficiency
PDT.
superior
PDT
effect
uptake
via
render
EB
series
pronounced
inhibition
under
red
light
or
sunlight
irradiation.
Moreover,
hydrogel,
constructed
from
oxidized
dextran
quaternized
chitosan,
facilitates
localization
sustained
retention
PSs,
accelerating
healing
biofilm-infected
wounds.
This
PS-based
could
provide
user-friendly
wound
treatment
prevention
infections.
Nano-Micro Letters,
Год журнала:
2021,
Номер
14(1)
Опубликована: Дек. 2, 2021
Abstract
Conductive
biomaterials
based
on
conductive
polymers,
carbon
nanomaterials,
or
inorganic
nanomaterials
demonstrate
great
potential
in
wound
healing
and
skin
tissue
engineering,
owing
to
the
similar
conductivity
human
skin,
good
antioxidant
antibacterial
activities,
electrically
controlled
drug
delivery,
photothermal
effect.
However,
a
review
highlights
design
application
of
for
engineering
is
lacking.
In
this
review,
fabrication
methods
with
various
structural
forms
including
film,
nanofiber,
membrane,
hydrogel,
sponge,
foam,
acellular
dermal
matrix
applications
corresponding
mechanism
promoting
process
were
summarized.
The
approaches
that
realize
their
value
wounds
via
three
main
strategies
(electrotherapy,
dressing,
assessment)
reviewed.
as
dressing
when
facing
different
acute
chronic
(infected
diabetic
wound)
monitoring
discussed
detail.
challenges
perspectives
designing
developing
multifunctional
are
proposed
well.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2022,
Номер
17(3), С. 353 - 384
Опубликована: Янв. 24, 2022
Bacterial
infection
and
the
ever-increasing
bacterial
resistance
have
imposed
severe
threat
to
human
health.
And
contamination
could
significantly
menace
wound
healing
process.
Considering
sophisticated
process,
novel
strategies
for
skin
tissue
engineering
are
focused
on
integration
of
bioactive
ingredients,
antibacterial
agents
included,
into
biomaterials
with
different
morphologies
improve
cell
behaviors
promote
healing.
However,
a
comprehensive
review
anti-bacterial
dressing
enhance
has
not
been
reported.
In
this
review,
various
as
dressings
will
be
discussed.
Different
kinds
agents,
including
antibiotics,
nanoparticles
(metal
metallic
oxides,
light-induced
agents),
cationic
organic
others,
their
recent
advances
summarized.
Biomaterial
selection
fabrication
structures
forms,
films,
hydrogel,
electrospun
nanofibers,
sponge,
foam
three-dimension
(3D)
printed
scaffold
regeneration,
elaborated
Current
challenges
future
perspectives
presented
in
multidisciplinary
field.
We
envision
that
provide
general
insight
elegant
design
further
refinement
dressing.
Journal of Functional Biomaterials,
Год журнала:
2023,
Номер
14(5), С. 244 - 244
Опубликована: Апрель 26, 2023
Silver
nanoparticles
(AgNPs)
are
the
most
investigated
antibacterial
agents
against
multidrug
resistant
(MDR)
pathogens.
They
can
lead
to
cellular
death
by
means
of
different
mechanisms,
damaging
several
cell
compartments,
from
external
membrane,
enzymes,
DNA
and
proteins;
this
simultaneous
attack
amplifies
toxic
effect
on
bacteria
with
respect
traditional
antibiotics.
The
effectiveness
AgNPs
MDR
is
strongly
correlated
their
chemical
morphological
properties,
which
influence
pathways
involved
in
damage.
In
review,
AgNPs’
size,
shape
modification
functional
groups
or
other
materials
reported,
both
investigate
synthetic
nanoparticles’
modifications
evaluate
related
activity.
Indeed,
understanding
conditions
for
obtaining
performing
could
help
tailor
new
improved
silver-based
combat
resistance.
Bioactive Materials,
Год журнала:
2022,
Номер
24, С. 197 - 235
Опубликована: Дек. 23, 2022
Chronic
wounds
have
become
one
of
the
most
important
issues
for
healthcare
systems
and
are
a
leading
cause
death
worldwide.
Wound
dressings
necessary
to
facilitate
wound
treatment.
Engineering
may
substantially
reduce
healing
time,
risk
recurrent
infections,
disability
costs
associated.
In
path
engineering
an
ideal
dressing,
hydrogels
played
role.
Hydrogels
3D
hydrophilic
polymeric
structures
that
can
provide
protective
barrier,
mimic
native
extracellular
matrix
(ECM),
humid
environment.
Due
their
advantages,
(with
different
architectural,
physical,
mechanical,
biological
properties)
been
extensively
explored
as
dressing
platforms.
Here
we
describe
recent
studies
on
applications
with
strong
focus
interplay
between
fabrication
method
used
performance
achieved.
Moreover,
review
categories
additives
which
enhance
regeneration
using
hydrogel
dressings.
Hydrogel
promises
generation
smart
solutions
solve
this
pressing
problem,
enabling
key
functionalities
such
bacterial
growth
inhibition,
enhanced
re-epithelialization,
vascularization,
improved
recovery
tissue
functionality,
overall,
accelerated
effective
healing.
Chronic
wound
healing
is
an
important
and
basic
issue
in
medical
healthcare
fields.
Recently,
stimuli-responsive
hydrogel
systems
have
emerged
as
promising
drug
delivery
carriers
for
management.
However,
given
to
the
limited
therapeutic
outcomes,
new
efficient
treatment
are
urgently
needed.
Here,
development
of
a
2D
MXene-based
system
highly
photo-
magnetic-responsive
oriented
deep
chronic
wounds
repair
presented.
The
intelligent
responsive
composed
MXene-wrapped
magnetic
colloids
poly(N-isopropyl
acrylamide)-alginate
dual-network
hydrogels.
It
demonstrated
that
exhibits
multiple
response
capability
controllable
ability,
which
can
reduce
toxic
side
effects
drugs
promote
process
well.
Notably,
practical
performance
by
applying
it
full-thickness
cutaneous
subcutaneous
infected
rat
model,
indicates
great
prospect
clinical
other
related
biomedical
ACS Nano,
Год журнала:
2022,
Номер
16(11), С. 19491 - 19508
Опубликована: Ноя. 2, 2022
Chronic
wounds
are
characterized
by
long-term
inflammation
and
persistent
infection,
which
make
them
difficult
to
heal.
Therefore,
an
urgent
desire
is
develop
a
multifunctional
wound
dressing
that
can
prevent
infection
promote
healing
creating
favorable
microenvironment.
In
this
study,
curcumin-based
metal-organic
framework
(QCSMOF-Van),
loaded
with
vancomycin
coated
quaternary
ammonium
salt
chitosan
(QCS),
was
prepared.
Multifunctional
composite
hydrogels
were
conveniently
synthesized
combining
methacrylic
anhydride
modified
gelatin
oxidized
sodium
alginate
QCSMOF-Van
through
radical
polymerization
Schiff
base
reaction.
It
important
note
the
could
capture
bacteria
positive
charges
on
surface
of
QCS.
process,
due
synergistic
effect
broad-spectrum
antibacterial
Zn2+
vancomycin,
metabolism
well
inhibited,
efficient
capturing
rapid
killing
achieved.
The
precisely
regulate
balance
M1/M2
phenotypes
macrophages,
thereby
promoting
regeneration
nerves
blood
vessels,
promotes
chronic
wounds.
This
advanced
cascade
management
strategy
for
tissue
highlights
potential
in
dressings.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Июль 5, 2022
Abstract
Traditional
antibiotic
treatment
has
limited
efficacy
for
the
drug-tolerant
bacteria
present
in
biofilms
because
of
their
unique
metabolic
conditions
biofilm
infection
microenvironment.
Modulating
microenvironment
may
influence
state
and
provide
alternative
therapeutic
routes.
In
this
study,
photodynamic
therapy
is
used
not
only
to
eradicate
methicillin-resistant
Staphylococcus
aureus
normoxic
condition,
but
also
potentiate
hypoxic
microenvironment,
which
induces
anaerobic
metabolism
activates
antibacterial
activity
metronidazole.
Moreover,
therapy-activated
chemotherapy
can
polarize
macrophages
a
M2-like
phenotype
promote
repair
infected
wounds
mice.
This
modulation
strategy,
whereby
potentiated
synergize
with
chemotherapy,
provides
an
pathway
efficient
biofilm-associated
infections.
