Multifunctional PtCuTe Nanosheets with Strong ROS Scavenging and ROS‐Independent Antibacterial Properties Promote Diabetic Wound Healing

Advanced Materials, Год журнала: 2023, Номер 36(8)

Опубликована: Сен. 19, 2023

Abstract Nanozymes, as one of the most efficient reactive oxygen species (ROS)‐scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving catalytic efficiency Pt‐based nanozymes (e.g., PtCu, best systems), they still display quite limited ROS scavenging capacity and ROS‐dependent antibacterial effects on bacteria or immunocytes, which leads to uncontrolled poor Hence, a new class multifunctional PtCuTe nanosheets with excellent catalytic, ROS‐independent antibacterial, proangiogenic, anti‐inflammatory, immuno‐modulatory properties for boosting healing, is reported. The show stronger better than PtCu. It also revealed that can enhance vascular tube formation, stimulate macrophage polarization toward M2 phenotype improve fibroblast mobility, outperforming conventional Moreover, promotes crosstalk between different cell types form positive feedback loop. Consequently, stimulates proregenerative environment relevant populations ensure normal tissue repair. Utilizing mouse model, it demonstrated significantly facilitated regeneration highly vascularized skin, percentage closure being over 90% 8th day, among reported comparable biomaterials.

Язык: Английский

---

Mussel-inspired collagen-hyaluronic acid composite scaffold with excellent antioxidant properties and sustained release of a growth factor for enhancing diabetic wound healing

Materials Today Bio, Год журнала: 2022, Номер 15, С. 100320 - 100320

Опубликована: Июнь 1, 2022

Long-term non-healing diabetic wounds are always a serious challenge and global healthcare burden that needs to be resolved urgently in the clinic. Prolonged inflammation impaired angiogenesis main direct causes of wounds. With development polymer biomaterials, various wound dressings have been created, but few them applied clinical management Here, we developed mussel-inspired bioactive scaffold consisting mainly collagen hyaluronic acid, which natural biopolymer materials contained human tissues. First, fabricated different polydopamine modified lyophilized acid scaffolds under concentrations dopamine alkaline solutions, 0.5, 1, 2 ​mg/mL, so named CHS-PDA-0.5, CHS-PDA-1, CHS-PDA-2. After testing their physical chemical properties, antioxidant effect, regulation, as well drug loading release capabilities, obtained endothelial growth factor (EGF)-loaded dressing, [email protected], can resist reactive oxygen species (ROS) promote regeneration chronic rats by reducing inflammation. In addition, showed excellent swelling ability, certain coagulation effect reasonable degradation. Therefore, has great potential used treatment low-cost easily available dressing accelerate healing.

Язык: Английский

---

Biomimetic Nanozyme-Decorated Hydrogels with H₂O₂-Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound

ACS Nano, Год журнала: 2023, Номер 17(17), С. 16854 - 16869

Опубликована: Авг. 25, 2023

Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels are promising systems for DFU-based wound management, their effectiveness is often hindered by the immune response and hostile microenvironment associated with uncontrollable accumulation of reactive oxygen species hypoxia. Here, we develop therapeutic dressing using biomimetic hydrogel system decoration catalase-mimic nanozyme, namely, MnCoO@PDA/CPH. The can be designed match mechanical electrical cues skins simultaneously H2O2-activated oxygenation ability. As proof concept, rat models created validate efficacy MnCoO@PDA/CPH in vivo. results indicate that developed promote DFU healing improve quality healed as featured alleviated proinflammatory, increased re-epithelialization, highly ordered collagen deposition, functional blood vessel growth.

Язык: Английский

---

Metal–Organic Frameworks and Their Composites for Chronic Wound Healing: From Bench to Bedside

Advanced Materials, Год журнала: 2023, Номер 36(2)

Опубликована: Авг. 1, 2023

Chronic wounds are characterized by delayed and dysregulated healing processes. As such, they have emerged as an increasingly significant threat. The associated morbidity socioeconomic toll clinically financially challenging, necessitating novel approaches in the management of chronic wounds. Metal-organic frameworks (MOFs) innovative type porous coordination polymers, with low toxicity high eco-friendliness. Documented anti-bacterial effects pro-angiogenic activity predestine these nanomaterials promising systems for treatment In this context, therapeutic applicability efficacy MOFs remain to be elucidated. It is, therefore, reviewed structural-functional properties their composite materials discusses how multifunctionality customizability can leveraged a clinical therapy

Язык: Английский

---

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

Materials Today Bio, Год журнала: 2022, Номер 15, С. 100308 - 100308

Опубликована: Июнь 1, 2022

Diabetic wounds have an extremely complex microenvironment of hyperglycemia, hypoxia and high reactive oxygen species (ROS). Therefore, the regulation management this may provide a new improved treatment method for chronic diabetic wound healing. Herein, glucose/ROS cascade-responsive nanozyme (CHA@GOx) was developed based on Ce-driven coassembly by special dual ligand (alendronic acid 2-methylimidazole) glucose oxidase (GOx). It possesses superoxide dismutase catalase mimic activities, which effectively remove excess ROS. In particular, it can catalyze excessive hydrogen peroxide generated oxidation reaction to produce oxygen, regulate balance wound, reduce toxic side effects GOx, thus achieving purpose synergistically repairing wounds.

Язык: Английский

---