Recent advances in responsive hydrogels for diabetic wound healing

Materials Today Bio, Год журнала: 2022, Номер 18, С. 100508 - 100508

Опубликована: Ноя. 30, 2022

Poor wound healing after diabetes mellitus remains a challenging problem, and its pathophysiological mechanisms have not yet been fully elucidated. Persistent bleeding, disturbed regulation of inflammation, blocked cell proliferation, susceptible infection impaired tissue remodeling are the main features diabetic healing. Conventional dressings, including gauze, films bandages, limited function. They generally act as physical barriers absorbers exudates, which fail to meet requirements whol process. Wounds in patients typically heal slowly due hyperglycemia within bed. Once bacterial cells develop into biofilms, wounds will exhibit robust drug resistance. Recently, application stimuli-responsive hydrogels, also known "smart hydrogels", for has attracted particular attention. The basic feature this system is capacities change mechanical properties, swelling ability, hydrophilicity, permeability biologically active molecules, etc., response various stimuli, temperature, potential hydrogen (pH), protease other biological factors. Smart hydrogels can improve therapeutic efficacy limit total toxicity according characteristics wounds. In review, we summarized mechanism It hoped that work provide some inspiration suggestions research field.

Язык: Английский

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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15962 - 15977

Опубликована: Авг. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Язык: Английский

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Ceria‐Based Therapeutic Antioxidants for Biomedical Applications

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Фев. 16, 2023

Abstract The growing interest in nanomedicine over the last 20 years has carved out a research field called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are employed to intervene disease‐critical biomolecular processes. Among many kinds of catalytic/enzyme‐mimetic investigated thus far, ceria nanoparticles stand from others owing their unique scavenging properties against biologically noxious free radicals, including reactive oxygen species (ROS) and nitrogen (RNS), exerting enzyme mimicry nonenzymatic activities. Much effort been made utilize as self‐regenerating antioxidative anti‐inflammatory agents for various diseases, given detrimental effects ROS RNS therein that need alleviation. In this context, review is intended provide an overview what makes merit attention disease therapy. introductory part describes characteristics oxygen‐deficient metal oxide. pathophysiological roles then presented, well mechanisms nanoparticles. Representative examples recent ceria‐nanoparticle‐based therapeutics summarized categorization into organ types, followed discussion on remaining challenges future directions.

Язык: Английский

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Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)

Опубликована: Апрель 13, 2023

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, oxidative damage to the microenvironment. Given their complex nature, diabetic remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown trigger hyperinflammation excessive cellular apoptosis, play pivotal role pathogenesis of wounds. ROS-scavenging nanosystems recently emerged as smart multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory pro-angiogenic ability treatments predestines these promising options for treatment Yet, this context, therapeutic applicability efficacy be elucidated. Herein, ROS is deciphered, properties strengths capacity summarized. In addition, current challenges such potential future directions discussed through clinical-translational lens.

Язык: Английский

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Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 196, С. 114778 - 114778

Опубликована: Март 16, 2023

Язык: Английский

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A Multifunctional Hydrogel with Photothermal Antibacterial and AntiOxidant Activity for Smart Monitoring and Promotion of Diabetic Wound Healing

Advanced Functional Materials, Год журнала: 2024, Номер 34(38)

Опубликована: Апрель 21, 2024

Abstract Persistent oxidative stress and bacterial infection are significant challenges that impede diabetic wound healing. By combining diagnosis treatment, pH variation on the tissue can be monitored in real time, precise treatment carried out promptly to promote In this study, a lipoic acid‐modified chitosa (LAMC) hydrogel is constructed via an amidation reaction, ceria oxide‐molybdenum disulfide nanoparticles with polydopamine layer (C@M@P), along carbon quantum dots (CDs) synthesized by hydrothermal method, loaded into hydrogel, thus developing diagnostic therapeutic (LAMC/CD‐C@M@P). incorporating CDs, exhibits high sensitivity reversibility under ultraviolet light. Furthermore, images of hydrogels collected using smartphones converted signals, providing means for early detection infection. Notably, LAMC/CD‐C@M@P excellent photothermal antibacterial capability against Staphylococcus aureus Escherichia coli remarkable antioxidant anti‐inflammatory abilities alleviate reactive oxygen species relieve inflammation response. summary, multifunctional offers great potential as innovative dressing platform, representing advancement chronic management.

Язык: Английский

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Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 1537 - 1560

Опубликована: Март 1, 2023

Abstract: Diabetes mellitus (DM) induced wound healing impairment remains a serious health problem and burden on the clinical obligation for high amputation rates. Based features of microenvironment, biomaterials loading specific drugs can benefit diabetic treatment. Drug delivery systems (DDSs) carry diverse functional substances to site. Nano-drug (NDDSs), benefiting from their related nano size, overcome limitations conventional DDSs application are considered as developing process in treatment field. Recently, number finely designed nanocarriers efficiently various (bioactive non-bioactive factors) have emerged circumvent constraints faced by traditional DDSs. This review describes recent advances nano-drug involved mitigating diabetes mellitus-based non-healing wounds. Keywords: drug system, nanotechnology, healing, nanoparticles

Язык: Английский

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Reactive oxygen species-sensitive materials: A promising strategy for regulating inflammation and favoring tissue regeneration

Smart Materials in Medicine, Год журнала: 2023, Номер 4, С. 427 - 446

Опубликована: Янв. 1, 2023

Reactive oxygen species (ROS), acting as essential mediators in the biological system, highly influence physiologic and pathologic processes of human body. The aberrant production ROS, caused by various diseases, may lead to inflammation cellular damages, well homeostasis disruption. In recent years, biomaterials sensitive stimuli have received increasing attention due their potential for achieving more specific diagnoses effective treatments. Particularly, ROS-responsive could be triggered ROS damaged tissue microenvironment release payloads or exert a therapeutically beneficial effect, consequently regulating elevated level downregulating oxidative stress promote regeneration. this review, we outline underlying mechanisms generation diseases summarize cutting-edge advances developing expedite inflammation-related regenerative medicine engineering applications body systems. particular, pointed out challenges shortcomings that current ROS-sensitive materials encounter, offer distinctive insights into field present solutions improved strategies.

Язык: Английский

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A multifunctional cascade nanoreactor based on Fe-driven carbon nanozymes for synergistic photothermal/chemodynamic antibacterial therapy

Acta Biomaterialia, Год журнала: 2023, Номер 168, С. 580 - 592

Опубликована: Июль 13, 2023

Язык: Английский

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Recent progress in nanozymes for the treatment of diabetic wounds

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(29), С. 6746 - 6761

Опубликована: Янв. 1, 2023

The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.

Язык: Английский

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