Recent
work
has
uncovered
relationships
between
evolutionarily
new
small
and
shallow
cerebral
indentations,
or
sulci,
human
behavior.
Yet,
this
relationship
remains
unexplored
in
the
lateral
parietal
cortex
(LPC)
parieto-occipital
junction
(LPOJ).
After
defining
thousands
of
sulci
a
young
adult
cohort,
we
revised
previous
LPC/LPOJ
sulcal
landscape
to
include
four
previously
overlooked,
small,
shallow,
variable
sulci.
One
these
(ventral
supralateral
occipital
sulcus,
slocs-v)
is
present
nearly
every
hemisphere
morphologically,
architecturally,
functionally
dissociable
from
neighboring
A
data-driven,
model-based
approach,
relating
depth
behavior
further
revealed
that
morphology
only
subset
including
slocs-v,
related
performance
on
spatial
orientation
task.
Our
findings
build
classic
neuroanatomical
theories
identify
targets
for
future
"precision
imaging"
studies
exploring
among
brain
structure,
function,
cognitive
abilities
individual
participants.
Journal of Neuroscience,
Год журнала:
2024,
Номер
unknown, С. e1714232024 - e1714232024
Опубликована: Фев. 21, 2024
Recent
work
suggests
that
indentations
of
the
cerebral
cortex,
or
sulci,
may
be
uniquely
vulnerable
to
atrophy
in
aging
and
Alzheimer's
disease
(AD)
posteromedial
cortex
(PMC)
is
particularly
pathology
accumulation.
However,
these
studies
did
not
consider
small,
shallow,
variable
tertiary
sulci
are
located
association
cortices
often
associated
with
human-specific
aspects
cognition.
Here,
we
manually
defined
4,362
PMC
432
hemispheres
216
human
participants
(50.5%
female)
found
smaller
putative
showed
more
age-
AD-related
thinning
than
larger,
consistent
strongest
effects
for
two
newly
uncovered
sulci.
A
model-based
approach
relating
sulcal
morphology
cognition
identified
a
subset
was
most
memory
executive
function
scores
older
adults.
These
findings
lend
support
retrogenesis
hypothesis
linking
brain
development
aging,
provide
new
neuroanatomical
targets
future
AD.
Significance
Statement
Large-scale
changes
cortical
structure
suggest
atrophy.
smallest
individually
folds
cognitive
development,
have
been
studied
aging.
investigate
first
time
(AD).
We
find
shallower
show
larger
(PMC),
classical
theories
developmental
trajectories
at
novel
anatomical
resolution
insight
into
relationships
between
individual
differences
structural
decline.
Journal of Neuroscience,
Год журнала:
2023,
Номер
43(14), С. 2552 - 2567
Опубликована: Фев. 24, 2023
Previous
findings
show
that
the
morphology
of
folds
(sulci)
human
cerebral
cortex
flatten
during
postnatal
development.
However,
previous
studies
did
not
consider
relationship
between
sulcal
and
cognitive
development
in
individual
participants.
Here,
we
fill
this
gap
knowledge
by
leveraging
cross-sectional
morphologic
neuroimaging
data
lateral
PFC
(LPFC)
from
participants
(6-36
years
old,
males
females;
Communications Biology,
Год журнала:
2023,
Номер
6(1)
Опубликована: Июнь 1, 2023
Abstract
Recent
studies
identify
a
surprising
coupling
between
evolutionarily
new
sulci
and
the
functional
organization
of
human
posteromedial
cortex
(PMC).
Yet,
no
study
has
compared
this
modern
PMC
sulcal
patterning
humans
non-human
hominoids.
To
fill
gap
in
knowledge,
we
first
manually
defined
over
2500
120
chimpanzee
(
Pan
Troglodytes
)
hemispheres
144
hemispheres.
We
uncovered
four
sulci,
quantitatively
identified
species
differences
incidence,
depth,
surface
area.
Interestingly,
some
are
more
common
others,
chimpanzees.
Further,
found
that
prominent
marginal
ramus
cingulate
sulcus
differs
significantly
species.
Contrary
to
classic
observations,
present
results
reveal
anatomy
substantially
chimpanzees—findings
which
lay
foundation
for
better
understanding
evolution
neuroanatomical-functional
neuroanatomical-behavioral
relationships
highly
expanded
region
cerebral
cortex.
Brain Structure and Function,
Год журнала:
2022,
Номер
227(7), С. 2543 - 2551
Опубликована: Авг. 6, 2022
The
relationship
between
structural
variability
in
late-developing
association
cortices
like
the
lateral
prefrontal
cortex
(LPFC)
and
development
of
higher-order
cognitive
skills
is
not
well
understood.
Recent
findings
show
that
morphology
LPFC
sulci
predicts
reasoning
performance;
this
work
led
to
observation
substantial
individual
one
these
sulci,
para-intermediate
frontal
sulcus
(pimfs).
Here,
we
sought
characterize
assess
its
behavioral
significance.
To
end,
identified
pimfs
a
developmental
cohort
72
participants,
ages
6-18.
Subsequent
analyses
revealed
presence
or
absence
ventral
component
was
associated
with
reasoning,
even
when
controlling
for
age.
This
finding
shows
lining
banks
can
support
complex
abilities
highlights
importance
considering
differences
local
exploring
neurodevelopmental
basis
cognition.
Journal of Cognitive Neuroscience,
Год журнала:
2023,
Номер
35(11), С. 1846 - 1867
Опубликована: Янв. 1, 2023
The
lateral
prefrontal
cortex
(LPFC)
is
an
evolutionarily
expanded
region
in
humans
that
critical
for
numerous
complex
functions,
many
of
which
are
largely
hominoid
specific.
Although
recent
work
shows
the
presence
or
absence
specific
sulci
anterior
LPFC
associated
with
cognitive
performance
across
age
groups,
it
unknown
whether
these
structures
relates
to
individual
differences
functional
organization
LPFC.
To
fill
this
gap
knowledge,
we
leveraged
multimodal
neuroimaging
data
from
two
samples
encompassing
82
young
adult
(aged
22-36
years)
and
show
dorsal
ventral
components
paraintermediate
frontal
sulcus,
pimfs,
present
distinct
morphological
(surface
area),
architectural
(thickness
myelination),
(resting-state
connectivity
networks)
properties.
We
further
contextualize
pimfs
within
classic
modern
cortical
parcellations.
Taken
together,
mark
transitions
anatomy
function,
metrics
These
results
emphasize
a
structure
consider
when
examining
anatomical
suggest
future
individual-level
parcellations
could
benefit
incorporating
sulcal
delineating
regions.
Journal of Neuroscience,
Год журнала:
2023,
Номер
43(39), С. 6697 - 6711
Опубликована: Авг. 24, 2023
Stimulation-evoked
signals
are
starting
to
be
used
as
biomarkers
indicate
the
state
and
health
of
brain
networks.
The
human
limbic
network,
often
targeted
for
stimulation
therapy,
is
involved
in
emotion
memory
processing.
Previous
anatomic,
neurophysiological,
functional
studies
suggest
distinct
subsystems
within
network
(Rolls,
2015).
Studies
using
intracranial
electrical
stimulation,
however,
have
emphasized
similarities
evoked
waveforms
across
network.
We
test
whether
these
stimulation-driven
signatures.
In
eight
patients
(four
male,
four
female)
with
drug-resistant
epilepsy,
we
stimulated
system
single-pulse
stimulation.
Reliable
corticocortical
potentials
(CCEPs)
were
measured
between
hippocampus
posterior
cingulate
cortex
(PCC)
amygdala
anterior
(ACC).
However,
CCEP
waveform
PCC
after
hippocampal
showed
a
unique
reliable
morphology,
which
term
"limbic
Hippocampus-Anterior
nucleus
thalamus-Posterior
cingulate,
HAP-wave."
This
HAP-wave
was
visually
separately
decoded
from
ACC
Diffusion
MRI
data
show
that
end
points
overlap
parolfactory
cingulum
bundle
rather
than
parahippocampal
cingulum,
suggesting
may
travel
through
fornix,
mammillary
bodies,
thalamus
(ANT).
further
confirmed
by
stimulating
ANT,
same
but
an
earlier
latency.
Limbic
stimulation-evoked
signatures
future
help
pathology
diagnosis.
