Recent
work
has
uncovered
relationships
between
evolutionarily
new
small
and
shallow
cerebral
indentations,
or
sulci,
human
behavior.
Yet,
this
relationship
remains
unexplored
in
the
lateral
parietal
cortex
(LPC)
parieto-occipital
junction
(LPOJ).
After
defining
thousands
of
sulci
a
young
adult
cohort,
we
revised
previous
LPC/LPOJ
sulcal
landscape
to
include
four
previously
overlooked,
small,
shallow,
variable
sulci.
One
these
(ventral
supralateral
occipital
sulcus,
slocs-v)
is
present
nearly
every
hemisphere
morphologically,
architecturally,
functionally
dissociable
from
neighboring
A
data-driven,
model-based
approach,
relating
depth
behavior
further
revealed
that
morphology
only
subset
including
slocs-v,
related
performance
on
spatial
orientation
task.
Our
findings
build
classic
neuroanatomical
theories
identify
targets
for
future
"precision
imaging"
studies
exploring
among
brain
structure,
function,
cognitive
abilities
individual
participants.
Journal of Neuroscience,
Год журнала:
2024,
Номер
unknown, С. e1714232024 - e1714232024
Опубликована: Фев. 21, 2024
Recent
work
suggests
that
indentations
of
the
cerebral
cortex,
or
sulci,
may
be
uniquely
vulnerable
to
atrophy
in
aging
and
Alzheimer's
disease
(AD)
posteromedial
cortex
(PMC)
is
particularly
pathology
accumulation.
However,
these
studies
did
not
consider
small,
shallow,
variable
tertiary
sulci
are
located
association
cortices
often
associated
with
human-specific
aspects
cognition.
Here,
we
manually
defined
4,362
PMC
432
hemispheres
216
human
participants
(50.5%
female)
found
smaller
putative
showed
more
age-
AD-related
thinning
than
larger,
consistent
strongest
effects
for
two
newly
uncovered
sulci.
A
model-based
approach
relating
sulcal
morphology
cognition
identified
a
subset
was
most
memory
executive
function
scores
older
adults.
These
findings
lend
support
retrogenesis
hypothesis
linking
brain
development
aging,
provide
new
neuroanatomical
targets
future
AD.
Significance
Statement
Large-scale
changes
cortical
structure
suggest
atrophy.
smallest
individually
folds
cognitive
development,
have
been
studied
aging.
investigate
first
time
(AD).
We
find
shallower
show
larger
(PMC),
classical
theories
developmental
trajectories
at
novel
anatomical
resolution
insight
into
relationships
between
individual
differences
structural
decline.
Communications Biology,
Год журнала:
2023,
Номер
6(1)
Опубликована: Июнь 1, 2023
Abstract
Recent
studies
identify
a
surprising
coupling
between
evolutionarily
new
sulci
and
the
functional
organization
of
human
posteromedial
cortex
(PMC).
Yet,
no
study
has
compared
this
modern
PMC
sulcal
patterning
humans
non-human
hominoids.
To
fill
gap
in
knowledge,
we
first
manually
defined
over
2500
120
chimpanzee
(
Pan
Troglodytes
)
hemispheres
144
hemispheres.
We
uncovered
four
sulci,
quantitatively
identified
species
differences
incidence,
depth,
surface
area.
Interestingly,
some
are
more
common
others,
chimpanzees.
Further,
found
that
prominent
marginal
ramus
cingulate
sulcus
differs
significantly
species.
Contrary
to
classic
observations,
present
results
reveal
anatomy
substantially
chimpanzees—findings
which
lay
foundation
for
better
understanding
evolution
neuroanatomical-functional
neuroanatomical-behavioral
relationships
highly
expanded
region
cerebral
cortex.
Journal of Cognitive Neuroscience,
Год журнала:
2023,
Номер
35(11), С. 1846 - 1867
Опубликована: Янв. 1, 2023
The
lateral
prefrontal
cortex
(LPFC)
is
an
evolutionarily
expanded
region
in
humans
that
critical
for
numerous
complex
functions,
many
of
which
are
largely
hominoid
specific.
Although
recent
work
shows
the
presence
or
absence
specific
sulci
anterior
LPFC
associated
with
cognitive
performance
across
age
groups,
it
unknown
whether
these
structures
relates
to
individual
differences
functional
organization
LPFC.
To
fill
this
gap
knowledge,
we
leveraged
multimodal
neuroimaging
data
from
two
samples
encompassing
82
young
adult
(aged
22-36
years)
and
show
dorsal
ventral
components
paraintermediate
frontal
sulcus,
pimfs,
present
distinct
morphological
(surface
area),
architectural
(thickness
myelination),
(resting-state
connectivity
networks)
properties.
We
further
contextualize
pimfs
within
classic
modern
cortical
parcellations.
Taken
together,
mark
transitions
anatomy
function,
metrics
These
results
emphasize
a
structure
consider
when
examining
anatomical
suggest
future
individual-level
parcellations
could
benefit
incorporating
sulcal
delineating
regions.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 15, 2024
Abstract
Background
Emotion-related
impulsivity
(ERI)
describes
the
trait-like
tendency
toward
poor
self-control
when
experiencing
strong
emotions.
ERI
has
been
shown
to
be
elevated
across
psychiatric
disorders
and
predictive
of
onset
worsening
syndromes.
Recent
work
correlated
scores
with
neuroanatomy
orbitofrontal
cortex
(OFC).
Informed
by
a
growing
body
research
indicating
that
morphology
cortical
folds
(sulci)
can
produce
insights
into
behavioral
outcomes,
present
study
modeled
association
between
sulcal
OFC
at
finer
scale
than
previously
conducted.
Methods
Analyses
were
conducted
in
transdiagnostic
sample
118
individuals
broad
range
We
first
manually
defined
over
2000
sulci
participants.
then
implemented
model-based
LASSO
regression
relate
test
whether
effects
specific
as
compared
non-emotion-related
impulsivity.
Results
The
revealed
bilateral
associations
depth
eight
sulci.
These
not
observed
In
addition,
we
identified
new
transverse
component
olfactory
sulcus
every
hemisphere
is
dissociable
from
longitudinal
based
on
anatomical
features
correlation
behavior,
which
could
serve
biomarker.
Conclusions
results
this
data-driven
investigation
provide
greater
neuroanatomical
neurodevelopmental
specificity
how
related
ERI.
As
such,
findings
link
characteristics
trait
highly
psychopathology.
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Май 25, 2024
The
capacity
to
learn
enabled
the
human
species
adapt
various
challenging
environmental
conditions
and
pass
important
achievements
on
next
generation.
A
growing
body
of
research
suggests
links
between
neocortical
folding
properties
numerous
aspects
behavior,
but
their
impact
enhanced
learning
remains
unexplored.
Here
we
leverage
three
training
cohorts
demonstrate
that
higher
levels
premotor
cortical
reliably
predict
individual
long-term
gains
in
a
new
motor
task,
above
beyond
initial
performance
differences.
Individual
folding-related
predisposition
was
found
be
independent
thickness
intracortical
microstructure,
dependent
larger
surface
area
regions.
We
further
show
learning-relevant
features
occurred
close
spatial
proximity
practice-induced
structural
brain
plasticity.
Our
results
suggest
link
behavioral
adaptability.
Recent
work
has
uncovered
relationships
between
evolutionarily
new
small
and
shallow
cerebral
indentations,
or
sulci,
human
behavior.
Yet,
this
relationship
remains
unexplored
in
the
lateral
parietal
cortex
(LPC)
parieto-occipital
junction
(LPOJ).
After
defining
thousands
of
sulci
a
young
adult
cohort,
we
revised
previous
LPC/LPOJ
sulcal
landscape
to
include
four
previously
overlooked,
small,
shallow,
variable
sulci.
One
these
(ventral
supralateral
occipital
sulcus,
slocs-v)
is
present
nearly
every
hemisphere
morphologically,
architecturally,
functionally
dissociable
from
neighboring
A
data-driven,
model-based
approach,
relating
depth
behavior
further
revealed
that
morphology
only
subset
including
slocs-v,
related
performance
on
spatial
orientation
task.
Our
findings
build
classic
neuroanatomical
theories
identify
targets
for
future
“precision
imaging”
studies
exploring
among
brain
structure,
function,
cognitive
abilities
individual
participants.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 25, 2023
The
lateral
prefrontal
cortex
(LPFC)
is
an
evolutionarily
expanded
region
in
humans
that
critical
for
numerous
complex
functions,
many
of
which
are
largely
hominoid-specific.
While
recent
work
shows
the
presence
or
absence
specific
sulci
anterior
LPFC
associated
with
cognitive
performance
across
age
groups,
it
unknown
whether
these
structures
relates
to
individual
differences
functional
organization
LPFC.
To
fill
this
gap
knowledge,
we
leveraged
multimodal
neuroimaging
data
from
72
young
adult
aged
22-36
and
show
dorsal
ventral
components
paraintermediate
frontal
sulcus
(pimfs)
present
distinct
morphological
(surface
area),
architectural
(thickness
myelination),
(resting-state
connectivity
networks)
properties.
We
further
contextualize
pimfs
within
classic
modern
cortical
parcellations.
Taken
together,
mark
transitions
anatomy
function
LPFC,
metrics
These
results
emphasize
a
structure
consider
when
examining
anatomical
highlight
importance
considering
investigating
structural
features
cortex.
