Journal of Gastrointestinal Oncology,
Год журнала:
2023,
Номер
14(2), С. 1064 - 1076
Опубликована: Апрель 1, 2023
A
significant
desmoplastic
response,
particularly
in
the
fibroblasts,
is
a
characteristic
of
pancreatic
ductal
adenocarcinoma
(PDAC).
Increasing
evidence
has
shown
that
cancer-associated
fibroblasts
(CAFs)
assist
tumor
development,
invasion,
and
metastasis
PDAC.
However,
CAFs-derived
molecular
determinants
regulate
mechanisms
PDAC
have
not
been
fully
characterized.The
expression
microRNA
125b-5p
(miR-125b-5p)
Pancreas
Cancer
(PC)
tissue
para-cancerous
normal
was
examined
using
Polymerase
Chain
Reaction
(PCR).
Cell
counting
kit-8
(CCK8),
wound
healing,
transwell
experiments
were
utilized
to
assess
effect
miR-125b-5p.
Using
cell
luciferase
activity
test
bioinformatics,
it
demonstrated
miR-125b-5p
may
bind
3'-untranslated
region
(3'-UTR)
adenomatous
polyposis
coli
(APC),
thereby
limiting
progression
cancer.PDAC
cells
are
prompted
proliferate,
undergo
epithelial-mesenchymal
transition
(EMT),
spread.
Importantly,
CAFs
release
exosomes
into
cells,
which
significantly
increase
level
those
cells.
Meanwhile,
cancer
lines
tissues
considerably
higher
expression.
MiR-125b-5p's
elevated
mechanically
suppresses
APC
accelerates
spread
cancer.Exosomes
released
by
promote
growth,
metastasis.
Exosomal
inhibition
offers
an
alternate
strategy
for
combating
basic
malady
Cells,
Год журнала:
2023,
Номер
12(3), С. 447 - 447
Опубликована: Янв. 30, 2023
Colorectal
cancer
(CRC)
represents
one
of
the
most
common
cancers
worldwide,
with
a
high
mortality
rate
despite
decreasing
incidence
and
new
diagnostic
therapeutic
strategies.
CRC
arises
from
both
epidemiologic
molecular
backgrounds.
In
addition
to
hereditary
factor
genetic
mutations,
strongly
varying
is
closely
linked
chronic
inflammatory
disorders
intestine
terrible
dietary
habits.
The
Wnt
signalling
pathway
complex
regulatory
network
that
implicated
in
many
physiological
processes,
including
occurrence,
development,
prognosis,
invasion,
metastasis.
It
currently
believed
include
classical
Wnt/β-catenin,
Wnt/PCP,
Wnt/Ca2+.
this
review,
we
summarise
recent
mechanisms
potential
regulators
three
branches
CRC.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Апрель 27, 2024
Abstract
Circadian
rhythms
are
present
in
almost
all
cells
and
play
a
crucial
role
regulating
various
biological
processes.
Maintaining
stable
circadian
rhythm
is
essential
for
overall
health.
Disruption
of
this
can
alter
the
expression
clock
genes
cancer-related
genes,
affect
many
metabolic
pathways
factors,
thereby
affecting
function
immune
system
contributing
to
occurrence
progression
tumors.
This
paper
aims
elucidate
regulatory
effects
BMAL1,
other
on
cells,
reveal
molecular
mechanism
rhythm’s
involvement
tumor
its
microenvironment
regulation.
A
deeper
understanding
has
potential
provide
new
strategies
treatment
cancer
immune-related
diseases.
Seminars in Cancer Biology,
Год журнала:
2023,
Номер
91, С. 99 - 109
Опубликована: Март 7, 2023
The
circadian
rhythm
is
regulated
by
an
intrinsic
time-tracking
system,
composed
both
of
a
central
and
peripheral
clock,
which
influences
the
cycles
activities
sleep
individual
over
24
h.
At
molecular
level,
begins
when
two
basic
helix-loop-helix/Per-ARNT-SIM
(bHLH-PAS)
proteins,
BMAL-1
CLOCK,
interact
with
each
other
to
produce
BMAL-1/CLOCK
heterodimers
in
cytoplasm.
target
genes
encode
for
repressor
components
cryptochrome
(Cry1
Cry2)
Period
proteins
(Per1,
Per2
Per3).
It
has
been
recently
demonstrated
that
disruption
associated
increased
risk
developing
obesity
obesity-related
diseases.
In
addition,
it
plays
key
role
tumorigenesis.
Further,
association
between
disruptions
incidence
progression
several
types
cancer
(e.g.,
breast,
prostate,
colorectal
thyroid
cancer)
found.
As
perturbation
adverse
metabolic
consequences
obesity)
at
same
time
tumor
promoter
functions,
this
manuscript
aim
report
how
aberrant
rhythms
affect
development
prognosis
different
cancers
(breast,
colon
rectal
focusing
on
human
studies
aspects.
Trends in cancer,
Год журнала:
2023,
Номер
10(3), С. 196 - 207
Опубликована: Ноя. 23, 2023
Circadian
timekeeping
mechanisms
and
cell
cycle
regulation
share
thematic
biological
principles
in
responding
to
signals,
repairing
cellular
damage,
coordinating
metabolism,
allocating
resources
for
optimal
function.
Recent
studies
show
interactions
between
regulators
circadian
clock
components,
offering
insights
into
potential
cancer
treatment
approaches.
Understanding
control
of
metabolism
informs
timing
therapies
reduce
adverse
effects
enhance
efficacy.
adaptability
lifestyle
factors,
such
as
activity,
sleep,
nutrition
sheds
light
on
their
impact
cancer.
Leveraging
regulatory
prevention
care
is
vital,
most
risk
stems
from
modifiable
lifestyles.
Monitoring
factors
aids
assessment
targeted
interventions
across
the
continuum.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 22, 2024
Abstract
The
circadian
clock,
a
fundamental
biological
regulator,
governs
essential
cellular
processes
in
health
and
disease.
Circadian-based
therapeutic
strategies
are
increasingly
gaining
recognition
as
promising
avenues.
Aligning
drug
administration
with
the
rhythm
can
enhance
treatment
efficacy
minimize
side
effects.
Yet,
uncovering
optimal
timings
remains
challenging,
limiting
their
widespread
adoption.
In
this
work,
we
introduce
high-throughput
approach
integrating
live-imaging
data
analysis
techniques
to
deep-phenotype
cancer
cell
models,
evaluating
rhythms,
growth,
responses.
We
devise
streamlined
process
for
profiling
sensitivities
across
different
times
of
day,
identifying
windows
responsive
types
combinations.
Finally,
implement
multiple
computational
tools
uncover
genetic
factors
shaping
time-of-day
sensitivity.
Our
versatile
is
adaptable
various
facilitating
its
broad
application
relevance.
Ultimately,
research
leverages
rhythms
optimize
anti-cancer
treatments,
improved
outcomes
transformative
strategies.
