Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Molecular
phototheranostic
dyes
are
of
eminent
interest
for
oncological
diagnosis
and
imaging‐guided
phototherapy.
However,
it
remains
challenging
to
develop
photosensitizers
(PSs)
that
simultaneously
integrate
high‐contrast
photoacoustic
imaging
efficient
therapeutic
capabilities.
In
this
work,
a
supramolecular
strategy
is
employed
construct
molecular
pair
agent
via
the
direct
self‐assembly
two
cyanines,
C5TNa
(anionic)
Cy‐Et
(cationic).
The
Coulombic
interactions
between
facilitate
formation
complementary
cyanine
(C5T‐ET)
creation
CT‐J‐type
aggregates
in
water.
This
results
completely
quenched
fluorescence
significantly
enhances
nonradiative
deactivation
(≈22
ps),
leading
3.3‐fold
increase
photothermal
conversion
efficiency
7.1‐fold
enhancement
response
compared
indocyanine
green
(ICG).
As
result,
J‐type
aggregate
demonstrates
high
capability
remarkable
antitumor
efficacy
vivo,
highlighting
its
potential
clinical
applications.
work
provides
strong
experimental
evidence
superior
performance
enhancing
photosensitization
response.
It
believed
will
propel
advancement
controllable
dye
J‐aggregates
contribute
practical
implementation
phototherapy
vivo.
Advanced Materials,
Год журнала:
2023,
Номер
35(20)
Опубликована: Март 3, 2023
Molecular
fluorophores
with
the
second
near-infrared
(NIR-II)
emission
hold
great
potential
for
deep-tissue
bioimaging
owing
to
their
excellent
biocompatibility
and
high
resolution.
Recently,
J-aggregates
are
used
construct
long-wavelength
NIR-II
emitters
as
optical
bands
show
remarkable
red
shifts
upon
forming
water-dispersible
nano-aggregates.
However,
wide
applications
in
fluorescence
imaging
impeded
by
limited
varieties
of
J-type
backbone
serious
quenching.
Herein,
a
bright
benzo[c]thiophene
(BT)
J-aggregate
fluorophore
(BT6)
anti-quenching
effect
is
reported
highly
efficient
phototheranostics.
The
BT
manipulated
have
Stokes
shift
over
400
nm
aggregation-induced
(AIE)
property
conquering
self-quenching
issue
fluorophores.
Upon
BT6
assemblies
an
aqueous
environment,
absorption
800
1000
boosted
more
than
41
26
folds,
respectively.
In
vivo
visualization
whole-body
blood
vessel
imaging-guided
phototherapy
results
verify
that
NPs
agent
cancer
This
work
develops
strategy
precisely
properties
biomedical
applications.
Advanced Materials,
Год журнала:
2023,
Номер
36(1)
Опубликована: Авг. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(20)
Опубликована: Март 17, 2023
Integrating
the
ultralong
excitation
wavelength,
high
extinction
coefficient,
and
prominent
photothermal
conversion
ability
into
a
single
agent
is
an
appealing
yet
significantly
challenging
task.
Herein,
precise
dual-acceptor
engineering
strategy
exploited
for
this
attempt
based
on
donor-acceptor
(D-A)
type
semiconductor
polymers
by
subtly
regulating
molar
proportions
of
two
employed
electron
acceptor
moieties
featuring
different
electronic
affinity
π-conjugation
degrees,
making
full
use
active
intramolecular
motion-induced
effect.
The
optimal
polymer
SP4
synchronously
shows
desirable
second
near-infrared
(NIR-II)
absorption,
extremely
satisfactory
behavior.
Consequently,
unprecedented
performance
NPs
1064
nm
laser-excited
photoacoustic
imaging
(PAI)-guided
therapy
(PTT)
demonstrated
tumor
diagnosis
complete
elimination.
ACS Nano,
Год журнала:
2024,
Номер
18(6), С. 4683 - 4703
Опубликована: Янв. 31, 2024
Organic
fluorescent
molecules
with
emission
in
the
second
near-infrared
(NIR-II)
biological
window
have
aroused
increasing
investigation
cancer
phototheranostics.
Among
these
studies,
Benzobisthiadiazole
(BBT),
high
electron
affinity,
is
widely
utilized
as
acceptor
constructing
donor–acceptor–donor
(D-A-D)
structured
fluorophores
intensive
(NIR)
absorption
and
NIR-II
fluorescence.
Until
now,
numerous
BBT-based
dyes
been
employed
tumor
phototheranostics
due
to
their
exceptional
structure
tunability,
biocompatibility,
photophysical
properties.
This
review
systematically
overviews
research
progress
of
small
molecular
focuses
on
molecule
design
bioapplications.
First,
engineering
strategies
fine-tune
properties
high-performance
are
discussed
detail.
Then,
applications
optical
imaging
phototherapy
highlighted.
Finally,
current
challenges
future
prospects
also
summarized.
believed
significantly
promote
further
BBT-derived
for
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(11)
Опубликована: Янв. 16, 2024
Abstract
Achieving
photothermal
therapy
(PTT)
at
ultralow
laser
power
density
is
crucial
for
minimizing
photo‐damage
and
allowing
higher
maximum
permissible
skin
exposure.
However,
this
requires
agents
to
possess
not
just
superior
conversion
efficiency
(PCE),
but
also
exceptional
near‐infrared
(NIR)
absorptivity.
J
‐aggregates,
exhibit
a
significant
redshift
narrower
absorption
peak
with
extinction
coefficient.
Nevertheless,
achieving
predictable
‐aggregates
through
molecular
design
remains
challenge.
In
study,
we
successfully
induced
desirable
J‐
aggregation
(λ
abs
max
:
968
nm,
ϵ:
2.96×10
5
M
−1
cm
,
λ
em
972
Φ
FL
6.2
%)
by
tuning
electrostatic
interactions
between
π‐conjugated
planes
manipulating
surface
potential
of
aromatic
ring‐fused
aza‐BODIPY
dyes.
Notably,
controlling
the
preparation
method
encapsulating
dyes
into
F‐127
polymer,
were
able
selectively
generate
H
‐/
respectively.
Furthermore,
exhibited
two
controllable
morphologies:
nanospheres
nanowires.
Importantly,
shortwave‐infrared
‐aggregated
nanoparticles
impressive
PCE
72.9
%
effectively
destroyed
cancer
cells
mice‐tumors
an
0.27
W
−2
(915
nm).
This
phototherapeutic
nano‐platform,
which
generates
behavior,
can
controllably
form
/
H‐
aggregates
selectable
aggregate
morphology,
valuable
paradigm
developing
tumor‐treatment
density.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
as
promising
treatment
options,
showcasing
immense
potential
in
addressing
both
oncologic
nononcologic
diseases.
Single‐component
organic
phototherapeutic
agents
(SCOPAs)
offer
advantages
compared
to
inorganic
or
multicomponent
nanomedicine,
including
better
biosafety,
lower
toxicity,
simpler
synthesis,
enhanced
reproducibility.
Nonetheless,
how
further
improve
the
therapeutic
effectiveness
of
SCOPAs
remains
a
challenging
research
area.
This
review
delves
deeply
into
strategies
performance
PDT
PTT
by
optimizing
structural
design
SCOPAs.
These
encompass
augmenting
reactive
oxygen
species
(ROS)
generation,
mitigating
dependence,
elevating
light
absorption
capacity,
broadening
region,
enhancing
conversion
efficiency
(PCE).
Additionally,
this
also
underscores
ideal
for
developing
with
balanced
PTT.
Furthermore,
synergies
are
highlighted
between
other
modalities
such
ferroptosis,
gas
therapy,
chemotherapy,
immunotherapy.
By
providing
comprehensive
analysis
these
strategies,
aspires
serve
valuable
resource
clinicians
researchers,
facilitating
wider
application
advancement
SCOPAs‐mediated
