Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy

Advanced Materials, Год журнала: 2023, Номер 35(51)

Опубликована: Май 17, 2023

Abstract Messenger RNA (mRNA) has received great attention in the prevention and treatment of various diseases due to success coronavirus disease 2019 (COVID‐19) mRNA vaccines (Comirnaty Spikevax). To meet therapeutic purpose, it is required that must enter target cells express sufficient proteins. Therefore, development effective delivery systems necessary crucial. Lipid nanoparticle (LNP) represents a remarkable vehicle indeed accelerated applications humans, as several mRNA‐based therapies have already been approved or are clinical trials. In this review, focus on mRNA‐LNP‐mediated anticancer therapy. It summarizes main strategies mRNA‐LNP formulations, discusses representative approaches cancer, points out current challenges possible future directions research field. hoped these delivered messages can help further improve application technology cancer

Язык: Английский

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Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review

Pharmaceutics, Год журнала: 2023, Номер 15(6), С. 1593 - 1593

Опубликована: Май 25, 2023

Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems for the of drugs other bioactives used in diagnosis, therapy, treatment procedures. These nanocarriers may enhance solubility permeability drugs, increase their bioavailability, extend residence time body, combining low toxicity with a targeted delivery. Nanostructured second generation differing from solid composition matrix. The use liquid together carrier allows it to load higher amount drug, drug release properties, its stability. Therefore, direct comparison between is needed. This review aims describe as systems, comparing both, while systematically elucidating production methodologies, physicochemical characterization, vitro vivo performance. In addition, concerns these focused on.

Язык: Английский

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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Язык: Английский

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Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 200, С. 114990 - 114990

Опубликована: Июль 7, 2023

Язык: Английский

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The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 361 - 372

Опубликована: Авг. 10, 2023

Язык: Английский

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The 60-year evolution of lipid nanoparticles for nucleic acid delivery

Nature Reviews Drug Discovery, Год журнала: 2024, Номер 23(9), С. 709 - 722

Опубликована: Июль 4, 2024

Язык: Английский

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Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications

Advanced Science, Год журнала: 2023, Номер 10(17)

Опубликована: Апрель 20, 2023

Extracellular vesicles (EVs) are transport secreted by living cells and released into the extracellular environment. Recent studies have shown that EVs serve as "messengers" in intercellular inter-organismal communication, both normal pathological processes. EVs, natural nanocarriers, can deliver bioactivators therapy with their endogenous properties. This review article describes engineering of sources, isolation method, cargo loading, boosting approach, adjustable targeting EVs. Furthermore, summarizes recent progress made EV-based delivery systems applications, including cancer, cardiovascular diseases, liver, kidney, nervous system COVID-19 emphasizes obstacles challenges therapies possible strategies.

Язык: Английский

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Strategies for non-viral vectors targeting organs beyond the liver

Nature Nanotechnology, Год журнала: 2023, Номер 19(4), С. 428 - 447

Опубликована: Дек. 27, 2023

Язык: Английский

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Chemically Modified Platforms for Better RNA Therapeutics

Chemical Reviews, Год журнала: 2024, Номер 124(3), С. 929 - 1033

Опубликована: Янв. 29, 2024

RNA-based therapies have catalyzed a revolutionary transformation in the biomedical landscape, offering unprecedented potential disease prevention and treatment. However, despite their remarkable achievements, these encounter substantial challenges including low stability, susceptibility to degradation by nucleases, prominent negative charge, thereby hindering further development. Chemically modified platforms emerged as strategic innovation, focusing on precise alterations either RNA moieties or associated delivery vectors. This comprehensive review delves into platforms, underscoring significance augmenting performance translational prospects of therapeutics. It encompasses an in-depth analysis various chemically that been instrumental propelling therapeutics toward clinical utility. Moreover, scrutinizes rationale behind diverse chemical modification techniques aiming at optimizing therapeutic efficacy molecules, facilitating robust management. Recent empirical studies corroborating enhancement through modifications are highlighted. Conclusively, we offer profound insights transformative impact drugs delineates prospective trajectories for future development integration.

Язык: Английский

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Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 5, 2024

Abstract Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this. Here, we reformulate lipid nanoparticles (LNPs) through adjustments in material structures compositions systematically the pulmonary hepatic (respectively) distribution expression. A combinatorial library of degradable-core based ionizable cationic lipids is designed, following by optimisation LNP compositions. Contrary current paradigms, our findings demonstrate that cholesterol phospholipid dispensable for functionality. Specifically, cholesterol-removal addresses persistent challenge preventing nanoparticle tissues. By modulating simplifying intrinsic components, concurrent translation achieved lung liver, respectively. This targeting strategy applicable existing with potential expand progress precise therapy diverse diseases.

Язык: Английский

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