Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Год журнала: 2024, Номер 124(13), С. 8307 - 8472

Опубликована: Июнь 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Язык: Английский

---

Engineered Probiotic Bio‐heterojunction with Robust Antibiofilm Modality via “Eating” Extracellular Polymeric Substances for Wound Regeneration

Advanced Materials, Год журнала: 2024, Номер 36(35)

Опубликована: Июнь 25, 2024

The compact three-dimensional (3D) structure of extracellular polymeric substances (EPS) within biofilms significantly hinders the penetration antimicrobial agents, making biofilm eradication challenging and resulting in persistent biofilm-associated infections. To address this challenge, a solution is proposed: probiotic bio-heterojunction (P-bioHJ) combining Lactobacillus rhamnosus with MXene (Ti

Язык: Английский

---

Chemical multiscale robotics for bacterial biofilm treatment

Chemical Society Reviews, Год журнала: 2024, Номер 53(5), С. 2284 - 2299

Опубликована: Янв. 1, 2024

A biofilm constitutes a bacterial community encased in sticky matrix of extracellular polymeric substances. These intricate microbial communities adhere to various host surfaces such as hard and soft tissues well indwelling medical devices. aggregates form robust substances (EPSs), leading the majority human infections. Such infections tend exhibit high resistance treatment, often progressing into chronic states. The EPS protects bacteria from hostile environment prevents penetration antibacterial agents. Modern robots at nano, micro, millimeter scales are highly attractive candidates for biomedical applications due their diverse functionalities, navigating confined spaces targeted multitasking. In this tutorial review, we describe key milestones strategies developed removal eradication biofilms using different sizes shapes. It can be seen that useful effective tools treating biofilms, thus preventing persistent infections, loss costly implanted devices, additional costs associated with hospitalization therapies.

Язык: Английский

---

Reactive Microneedle Patches with Antibacterial and Dead Bacteria‐Trapping Abilities for Skin Infection Treatment

Advanced Science, Год журнала: 2024, Номер 11(23)

Опубликована: Апрель 6, 2024

Abstract Bacterial skin infections are highly prevalent and pose a significant public health threat. Current strategies primarily focused on the inhibition of bacterial activation while disregarding excessive inflammation induced by dead bacteria remaining in body effect acidic microenvironment during therapy. In this study, novel dual‐functional MgB 2 microparticles integrated microneedle (MgB MN) patch is presented to kill eliminate for infection management. The not only can produce local alkaline promote proliferation migration fibroblasts keratinocytes, but also achieve >5 log inactivation. Besides, effectively mitigate bacteria‐induced through interaction with lipopolysaccharide (LPS). With incorporation these microparticles, resultant MN patches capture bacteria, thereby mitigating inflammation. Therefore, show good therapeutic efficacy managing animal infections, including abscesses wounds. These results indicate that reactive metal borides‐integrated hold great promise treatment clinical infections.

Язык: Английский

---

Environment‐Responsive Therapeutic Platforms for the Treatment of Implant Infection

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(26)

Опубликована: Май 15, 2023

Abstract The application of medical implants has greatly improved the survival rate and life quality patients. Nevertheless, in recent years, there are increasing cases implant dysfunction or failure because bacterial infections. Despite significant improvements biomedicine, still serious challenges treatment implant‐related With formation biofilms development resistance, these limitations lead to a low efficacy conventional antibiotics. To address challenges, it is urgent exploit innovative strategies for Based on ideas, environment‐responsive therapeutic platforms with high selectivity, drug minor dose‐limiting toxicity have attracted widespread attention. By using exogenous/endogenous stimuli, antibacterial activity therapeutics can be activated demand exhibit remarkable effects. Exogenous stimuli include photo, magnetism, microwave, ultrasound. Endogenous mainly pathological characteristics infections such as acidic pH, anomalous temperature, abnormal enzymatic activities. In this review, progress spatiotemporally controlled release/activation systematically summarized. Afterward, opportunities emerging highlighted. Finally, hoped that review will offer novel ideas techniques combat

Язык: Английский

---

Interdisciplinary‐Inspired Smart Antibacterial Materials and Their Biomedical Applications

Advanced Materials, Год журнала: 2023, Номер 36(17)

Опубликована: Июль 20, 2023

Abstract The discovery of antibiotics has saved millions lives, but the emergence antibiotic‐resistant bacteria become another problem in modern medicine. To avoid or reduce overuse antibacterial treatments, stimuli‐responsive materials, pathogen‐targeting nanoparticles, immunogenic nano‐toxoids, and biomimetic materials are being developed to make sterilization better smarter than conventional therapies. common goal smart (SAMs) is increase antibiotic efficacy function via an mechanism different from that order biological properties while reducing risk drug resistance. research development SAMs increasingly interdisciplinary because new designs require knowledge fields input/collaboration scientists fields. A good understanding energy conversion physiological characteristics cells bacteria, bactericidal structures components nature expected promote SAMs. In this review, importance multidisciplinary insights for emphasized, latest advances categorized discussed according pertinent disciplines including science, physiology, biomimicry.

Язык: Английский

---

Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 9, 2023

The advent of drug-resistant pathogens results in the occurrence stubborn bacterial infections that cannot be treated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating body's immune system to eliminate pathogenic bacteria has confirmed promising therapeutic strategies controlling infections. Subsequent studies found antimicrobial its own benefits and limitations, such as avoiding recurrence infection autoimmunity-induced side effects. Current indicate various antibacterial inducing regulation can achieve superior efficacy compared monotherapy alone. Therefore, summarizing recent advances nanomedicine immunomodulatory functions for combating is necessary. Herein, we briefly introduce crisis caused opportunity immunotherapy. Then, immune-involved multimodal therapy treatment infectious diseases was systematically summarized. Finally, prospects challenges combinational are discussed.

Язык: Английский

---

Neutrophil Function Conversion Driven by Immune Switchpoint Regulator against Diabetes‐Related Biofilm Infections

Advanced Materials, Год журнала: 2023, Номер 36(8)

Опубликована: Дек. 1, 2023

Abstract Reinforced biofilm structures and dysfunctional neutrophils induced by excessive oxidative stress contribute to the refractoriness of diabetes‐related infections (DRBIs). Herein, in contrast traditional antibacterial therapies, an immune switchpoint‐driven neutrophil function conversion strategy based on a deoxyribonuclease I loaded vanadium carbide MXene (DNase‐I@V 2 C) nanoregulator is proposed treat DRBIs via lysis redirecting functions from NETosis phagocytosis diabetes. Owing its intrinsic superoxide dismutase/catalase‐like activities, DNase‐I@V C effectively scavenges reactive oxygen species (ROS) high microenvironment maintain biological activity DNase‐I. By increasing depth penetration DNase‐I, thoroughly degrades extracellular DNA traps (NETs) polymeric substances, thus breaking physical barrier biofilms. More importantly, as switchpoint regulator, can skew toward intercepting ROS–NE/MPO–PAD4 activating ROS–PI3K–AKT–mTOR pathways diabetic microenvironment, thereby eliminating infections. Biofilm synergistic exert favorable therapeutic effects vitro vivo. This study serves proof‐of‐principle demonstration achieving with efficacy regulating reverse functions.

Язык: Английский

---

Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery

Advanced Science, Год журнала: 2024, Номер 11(14)

Опубликована: Янв. 28, 2024

Abstract Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era precision medicine that requires systematic knowledge nano‐biological interactions from multidisciplinary perspectives. To this end, review first provides an overview membrane‐disruption methods such as electroporation, sonoporation, photoporation, microfluidic delivery, and microinjection with merits high‐throughput enhanced efficiency for in vitro NDC delivery. The impact characteristics including particle size, shape, charge, hydrophobicity, elasticity on cellular uptake are elaborated several types systems aiming hierarchical targeting vivo reviewed. Emerging ex human/animal‐derived pathophysiological models further explored highly recommended use studies since they might mimic features fill translational gaps animals humans. exploration modern microscopy techniques precise nanoparticle (NP) tracking at cellular, organ, organismal levels informs tailored development NDCs application clinical translation. Overall, integrates latest insights into smart nanosystem engineering, physiological models, imaging‐based validation tools, all directed towards enhancing efficient intracellular NDCs.

Язык: Английский

---

Application and progress of nanozymes in antitumor therapy

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 130960 - 130960

Опубликована: Март 20, 2024

Tumors remain one of the major threats to public health and there is an urgent need design new pharmaceutical agents for their diagnosis treatment. In recent years, due rapid development nanotechnology, biotechnology, catalytic science, theoretical computing, subtlety has gradually made great progress in research related tumor Compared conventional drugs, enzymes can improve drug distribution enhance enrichment at site, thereby reducing side effects enhancing efficacy. Nanozymes also be used as tracking imaging reshape microenvironment, providing a versatile platform treatment malignancies. this paper, we review current status on oncology analyze novel therapeutic approaches mechanisms. To date, large number nanomaterials, such noble metal nonmetallic carbon-based have been shown able function like natural enzymes, particularly with significant advantages therapy. light this, authors systematically summarized evaluated construction, enzymatic activity, characteristics nanozymes respect modalities addition, application different types nicknames features years are detail. We conclude summary outlook study It hoped that will inspire researchers fields chemistry, biology, materials science contribute nano-enzymology.

Язык: Английский

---